Prevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis.

Gastrointestinal disorder and Helicobacter pylori infection in patients with rheumatoid arthritis

“…15 About 70%-80% of Japanese people who are over 40 years old are infected with H. pylori. 16 Upadhyay et al 17 and Goggin et al 18 reported that 50% of patients with RA were infected by H. pylori, and the prevalence was similar to that expected for an age-matched population. On the other hand, Caselli et al 19 reported a low prevalence of H. pylori infection, and concluded that this was caused by the use of NSAIDs.…”

A guideline for the treatment and prevention of nsaid-induced ulcers

“…However, this association has not been demonstrated in patients with NSAID-related ulcer (87)(88)(89)(90). In one study, however, gastropathy was more severe in H. pylori-positive patients (88).…”

Superiority of Lansoprazole vs Ranitidine in Healing Nonsteroidal Anti-inflammatory Drug–Associated Gastric Ulcers

“…[23][24][25] In a study comparing the mucosal eicosanoid synthesis in NSAID users with that in control subjects, Hudson and colleagues 26 showed that H pyloriinfected patients were protected from the prostaglandinlowering effects of the drugs.…”