Introduction: Helicobacter pylori is a gastrointestinal pathogen that was found to affect outcomes of many foregut operations. Our study aims to evaluate the impact of H. pylori and its treatment on short-term outcomes after laparoscopic sleeve gastrectomy (LSG). Methods: We analyzed 280 consecutive patients who underwent LSG by a single surgeon over 48 months. We compared patients with positive H. pylori pathology to those with negative pathology. We evaluated length of stay (LOS), 30 day complications, readmissions and emergency room visits, and excess weight loss at 1 year (EWL1). Results: Twenty-one (7.5%) of the 280 patients tested positive for H. pylori on postoperative pathology. There was no difference in major complication rates between the two groups. The average LOS was longer for the positive group (1.85 vs. 1.45; p = 0.02). Those in the positive group (23%) were more likely to require an ER visit or hospital admission related to their procedure when compared to the negative group (6.42%; OR = 3.93 [95% CI 1.28-12.04], p < 0.05). EWL1 was equivalent for both groups. Conclusion: The presence of H. pylori does not increase the risk of major complications after LSG and does not affect weight loss. However, it may be related to longer hospitalization and its treatment to higher readmission rates.