Prevalence of Helicobacter pylori Antibodies in Egyptians with Idiopathic Thrombocytopenic purpura and in the General Egyptian Population: A Comparative Study

Hanafi, Nesren F.; Mikhael, Irene Lewis; Younan, Doreen N.

doi:10.20546/ijcmas.2017.605.278

Cited by 8 publications

(12 citation statements)

References 23 publications

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“…In Northern Africa, a recent study in Egypt compared the prevalence of H. pylori antibodies in patients with idiopathic thrombocytopenic purpura and in the general Egyptian population[20]. Seropositivity of anti- Helicobacter IgM was higher in the general population (54.4%) when compared with patients with idiopathic thrombocytopenic purpura (28.9%).…”

Section: Prevalence Of Helicobacter Pylori In Africamentioning

confidence: 99%

“…Seropositivity of anti- Helicobacter IgM was higher in the general population (54.4%) when compared with patients with idiopathic thrombocytopenic purpura (28.9%). Also, seropositivity of anti- Helicobacter IgG was higher in the general population (79.8%) when compared with the controls[20]. In Morocco, Bounder et al[21] assessed H. pylori prevalence in subjects with and without symptoms of gastric disorders.…”

Section: Prevalence Of Helicobacter Pylori In Africamentioning

confidence: 99%

“…This greatly influenced the estimated prevalence of H. pylori in Africa. In fact, according to Hanafi et al[20] getting a positive result when testing for the presence of H. pylori antibodies in the blood or serum does not distinguish between previous contact and active infection.…”

Section: Challenges On the Prevalence Of Helicobacter Pylori In Africamentioning

confidence: 99%

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Infections with Helicobacter pylori and challenges encountered in Africa

Smith

Fowora

Pellicano

2019

WJG

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Helicobacter pylori ( H. pylori ) is the causative agent of gastritis, peptic ulcer disease, mucosa associated lymphoid tissue lymphoma and gastric cancer (GC). While this bacterium infects 50% of the world’s population, in Africa its prevalence reach as high as 80% as the infection is acquired during childhood. Risk factors for H. pylori acquisition have been reported to be mainly due to overcrowding, to have infected siblings or parent and to unsafe water sources. Despite this high H. pylori prevalence there still does not exist an African guideline, equivalent to the Maastricht V/Florence Consensus Report of the European Helicobacter and Microbiota Study Group for the management of this infection. In this continent, although there is a paucity of epidemiologic data, a contrast between the high prevalence of H. pylori infection and the low incidence of GC has been reported. This phenomenon is the so-called “African Enigma” and it has been hypothesized that it could be explained by environmental, dietary and genetic factors. A heterogeneity of data both on diagnosis and on therapy have been published. In this context, it is evident that in several African countries the increasing rate of bacterial resistance, mainly to metronidazole and clarithromycin, requires continental guidelines to recommend the appropriate management of H. pylori . The aim of this manuscript is to review current literature on H. pylori infection in Africa, in terms of prevalence, risk factors, impact on human health, treatment and challenges encountered so as to proffer possible solutions to reduce H. pylori transmission in this continent.

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Section: Prevalence Of Helicobacter Pylori In Africamentioning

confidence: 99%

Section: Prevalence Of Helicobacter Pylori In Africamentioning

confidence: 99%

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Infections with Helicobacter pylori and challenges encountered in Africa

Smith

Fowora

Pellicano

2019

WJG

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“…This test does not determine, however, whether the patient is currently infected, or had contact with H. pylori in the past. [12] In addition, these studies were performed most often in people with symptoms of the stomach or duodenum, which also suggests that the actual proportion of infected with this bacterium in Africa is lower than the statistics indicate. [1] The work on the infection and transmission of Helicobacter pylori suggests possible transmission routes such as person-person oral and oro-faecal-oral.…”

Section: Discussionmentioning

confidence: 99%

The incidence of infection, diagnosis and treatment of H. pylori in developing countries on the example of Kenya

Machaj

Jastrzębska

Cyboran

et al. 2020

J Educ Health Sport

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Introduction:One of the most common causes of bacterial infections in the world is Helicobacter pylori. It has developed mechanisms that allow it to survive in the acidic pH of the stomach. The bacterium contributes to the incidence of gastric ulcer and duodenal ulcer. Infected is about 50% of the world population, while in Africa the proportion is as high as 80%. Despite this there are still number of African guidelines for infection prevention and eradication of the bacterium. Most infections concerns children, adolescents and the elderly. Data on the diagnosis and treatment of patients in Kenya are inconsistent.[1] Doctors are based on international recommendations. No general insurance and a low level of affluence prevent diagnosis of patients at the level of developed countries. Access to endoscopy, and cultures have only wealthy people in big cities.Purpose: Examine the percentage of Helicobacter pylori infection among the people of Kenya, the analysis of the causes of its high value, comparing the diagnosis and treatment with European standards. Material and methodsAnalysis of causes of hospitalization in 227 hospital patients in Kenya. The majority of them has made winning the test of H. pylori antigen in stool. Analysis of the results of research carried out in 2010Subdepartment Medical Microbiology, Jomo Kenyatta University of Agriculture and Technology in Nairobi, Kenya, where the diagnostic methods was rapid urease test and histological tests. 13 ConclusionsThe proportion of patients infected with H. pylori in Chuka is 51.9%. Cause of inflammation of the stomach in almost 1/3 of hospitalized patients may be awareness of hygiene and drinking water unsuitable for consumption. Standards of treatment of patients infected with H. pylori do not differ from European guidelines.Purpose: Examine the percentage of Helicobacter pylori infection among the people of Kenya, the analysis of the causes of its high value and a reference to the results of research carried out on Jomo Kenyatta University of Agriculture and Technology in Nairobi, Kenya. Comparison of diagnosis and treatment with European standards.

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“…In Southern Africa, Walker et al [ 67 ] reported an overall prevalence of 75%, whereas, in Northern Africa, Bounder et al [ 68 ] found a prevalence of 92.6% in asymptomatic Moroccans and 89.6% in patients complaining of gastric symptoms regardless of age. Another study performed in Egypt revealed a lower prevalence in the general population of only 54.4% [ 69 ]. A study from Kenya pointed out a higher prevalence of H. pylori infection in children compared to adults, 73.3% versus 54.8% [ 70 ].…”

Section: H Pylori Peculiarities In Africamentioning

confidence: 99%

Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children

2022

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Helicobacter pylori is usually acquired during childhood. The reports from the last two decades pointed out a decrease in H. pylori prevalence across geographical areas worldwide compared to previously reported data. Most of the studies performed in America found an overall H. pylori infection prevalence of approximately 50%. The most important risk factors in America include being male, poor adherence or difficult access to treatment, and the lack of in-home water service. Despite the descending trend in prevalence worldwide, the overall prevalence in Africa remains very high (70%). Nevertheless, the prevalence of H. pylori in children without gastrointestinal who underwent screening was reported to be only 14.2%. The main risk factors in Africa are having a traditional pit or no toilet, poverty, birth order, source of drinking water, or being a farmer. Asia seems to have the widest variations in terms of H. pylori prevalence. Several risk factors were reported in Asia to be associated with this infection, such as lower income and educational level, house crowding, rural residence, ethnicity, the use of tanks as water supplies, alcohol drinking, active smoking, eating spicy food or raw uncooked vegetables, poor living conditions and sanitation. The overall prevalence of H. pylori infection in European children is almost 25%. Portugal has the highest prevalence of all European countries at 66.2% in children 13 years of age. The risk factors in European individuals consist of living in rural areas, eating unwashed fruits and vegetables, not washing hands after school, low parental education and unemployment, and short education duration. Further studies are required to identify the precise mechanisms involved in the discrepancies of H. pylori prevalence worldwide.

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Prevalence of Helicobacter pylori Antibodies in Egyptians with Idiopathic Thrombocytopenic purpura and in the General Egyptian Population: A Comparative Study

Cited by 8 publications

References 23 publications

Infections with Helicobacter pylori and challenges encountered in Africa

Infections with Helicobacter pylori and challenges encountered in Africa

The incidence of infection, diagnosis and treatment of H. pylori in developing countries on the example of Kenya

Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children

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