Prevalence of Helicobacter pylori and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates

Khoder, Ghalia; Muhammad, Jibran Sualeh; Mahmoud, Ibrahim; Soliman, Sameh S. M.; Burucoa, Christophe

doi:10.3390/pathogens8020044

Cited by 103 publications

(116 citation statements)

References 46 publications

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“…7 Among them, 46.6% were of Arab, 47.1% Asian, and 6.3% African origin. 7 Among them, 46.6% were of Arab, 47.1% Asian, and 6.3% African origin.…”

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

“…A prospective cross-sectional H pylori prevalence study was conducted in the United Arab Emirates by enrolling 350 healthy asymptomatic children and adults. 7 Among them, 46.6% were of Arab, 47.1% Asian, and 6.3% African origin. Stool antigen test (Premier Platinum HpSA) was used to assess H pylori infection status.…”

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

“…African origin participants had a higher prevalence (81.8%) when compared to Asian (46.7%) and Arab participants (30.7%, P < .0001). 7 Studies from Asia also addressed the prevalence of H pylori in healthy populations. In Korea, the trends in seroprevalence of H pylori among asymptomatic subjects within an 18-year period (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017), the risk factors for the infection, and the frequency of eradication therapy were addressed in a cross-sectional nationwide multicenter study.…”

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

“…6 In United Arab Emirates, the prevalence of H pylori was significantly different (P = .001) in tap water drinking individuals compared to bottled water drinkers (58.6% and 36.7%, respectively). 7 A long-term sampling analysis of raw and drinking water for fecal indicator bacteria (FIB) and H pylori DNA was conducted in Bogota, Colombia. 20 The monitored FIB included Escherichia coli, total coliforms, and spores of sulfite-reducing Clostridia.…”

Section: Water Supplymentioning

confidence: 99%

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Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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This review summarizes recent publications on the epidemiology of Helicobacter pylori. Two major systemic analyses, from Malaysia and Ethiopia, were published. The Brazilian Consensus Conference has stated that H pylori infection is an infectious disease with an indication for antimicrobial therapy. A continuous decrease in H pylori prevalence was reported from many regions worldwide, including Korea, China, Iran, and Austria. A cross‐sectional H pylori prevalence study conducted in the United Arab Emirates found 41% prevalence in a group of healthy children and adults. Several studies from Asia addressed H pylori prevalence in adults undergoing regular checkup. The largest of such studies, performed in Korea, involved 24 471 subjects and reported 41.5% seroprevalence. A relatively smaller study from East China on 3252 subjects reported 27.5% prevalence. In contrast, a study from Spain reported 87.2% seroprevalence. A report on the association between smoking and H pylori seropositivity was published on behalf of the Stomach Cancer Pooling (StoP) Project—a consortium of epidemiological studies of gastric cancer. Also, other potential risk factors, including occupational risk factors, water supply, and food were analyzed. Gastroesophageal reflux and sexual partners has been associated with a higher risk for H pylori acquisition, and gut microbiota was suggested to play a role in intrafamilial transmission of H pylori. Finally, in a few studies (from Mexico and Japan), the catalytic model for predicting the potential risk of acquiring H pylori infection in the future was used. As anticipated, a further decline in H pylori‐related disease was demonstrated by applying the modeling.

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“…7 Among them, 46.6% were of Arab, 47.1% Asian, and 6.3% African origin. 7 Among them, 46.6% were of Arab, 47.1% Asian, and 6.3% African origin.…”

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

Section: Other Prevalence Studies In the General Populationmentioning

confidence: 99%

Section: Water Supplymentioning

confidence: 99%

See 2 more Smart Citations

Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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“…pylori is a spiral-shaped gram-negative bacterium that has evolved various mechanisms to survive in the acidic environment of the human stomach. More than 50% of the global population has H. pylori in their upper gastrointestinal tract, with considerable geographical variations, with a higher prevalence in lower-income countries [16,17]. Infection with H. pylori is acquired (typically during early childhood) by the ingestion of contaminated food or water and is asymptomatic in up to 90% of people, however, some individuals develop acute gastritis, which may spontaneously resolve or may progress to chronic gastritis, PUD, or lead to premalignant lesions such as atrophic gastritis and GIM [18].…”

Section: Biology and Disease Associations Of H Pylori And Ebvmentioning

confidence: 99%

Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders

Dávila-Collado¹,

Jarquín-Durán²,

Dong

et al. 2020

Pathogens

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Epstein–Barr virus (EBV) and Helicobacter pylori (H. pylori) are two pathogens associated with the development of various human cancers. The coexistence of both microorganisms in gastric cancer specimens has been increasingly reported, suggesting that crosstalk of both pathogens may be implicated in the carcinogenesis process. Considering that chronic inflammation is an initial step in the development of several cancers, including gastric cancer, we conducted a systematic review to comprehensively evaluate publications in which EBV and H. pylori co-infection has been documented in patients with non-malignant gastroduodenal disorders (NMGDs), including gastritis, peptic ulcer disease (PUD), and dyspepsia. We searched the PubMed database up to August 2019, as well as publication references and, among the nine studies that met the inclusion criteria, we identified six studies assessing EBV infection directly in gastric tissues (total 949 patients) and three studies in which EBV infection status was determined by serological methods (total 662 patients). Due to the substantial methodological and clinical heterogeneity among studies identified, we could not conduct a meta-analysis. The overall prevalence of EBV + H. pylori co-infection in NMGDs was 34% (range 1.8% to 60%). A higher co-infection rate (EBV + H. pylori) was reported in studies in which EBV was documented by serological methods in comparison with studies in which EBV infection was directly assessed in gastric specimens. The majority of these studies were conducted in Latin-America and India, with most of them comparing NMGDs with gastric cancer, but there were no studies comparing the co-infection rate in NMGDs with that in asymptomatic individuals. In comparison with gastritis caused by only one of these pathogens, EBV + H. pylori co-infection was associated with increased severity of gastric inflammation. In conclusion, only relatively small studies testing EBV and H. pylori co-infection in NMGDs have been published to date and the variable report results are likely influenced by geographic factors and detection methods.

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Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

Tallman,

Miller,

Brandley

et al. 2024

American Journal of Biological Anthropology

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ObjectivesHelicobacter pylori (H. pylori)—a gastric bacteria affecting almost 50% of the global population and leading to ulcers and cancer in severe cases—is a growing health concern among Indigenous populations who report a high burden of reported poor general health and gastrointestinal distress. We test hypothesized associations between H. pylori exposure patterns and environmental, social, and biological conditions among a sample of 212 Indigenous Awajún adults (112 males, 100 females, ages 18–65 years) living in the northern Peruvian Amazon.Materials and MethodsDried blood spots were analyzed for H. pylori‐specific IgG using a recently developed enzyme‐linked immunosorbent assay. Resulting seropositivity rates and antibody concentrations, proxying past exposures to H. pylori were analyzed in relation to relevant environmental (toilet type, floor material, reported water quality), social (household size and education level), and biological (age, sex, BMI, blood pressure, immune and metabolic biomarkers) factors using multivariable regression analyses.ResultsWe found near ubiquitous seropositivity for H. pylori exposure in our sample (99.1% seropositive). In the regression analyses, elevations in H. pylori antibody concentrations were significantly higher among males compared to females (β = 0.36, p = 0.01). No associations were found with any other factors.DiscussionAnthropological research in the study communities suggests that the male bias in elevations of H. pylori antibody concentrations is related to cultural and biological factors. Future research is needed to further unravel these biocultural dynamics and determine whether elevations in H. pylori antibody concentrations have clinical relevance for gastrointestinal health outcomes in this population.

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Prevalence of Helicobacter pylori and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates

Cited by 103 publications

References 46 publications

Review: Epidemiology of Helicobacter pylori infection

Review: Epidemiology of Helicobacter pylori infection

Epstein–Barr Virus and Helicobacter Pylori Co-Infection in Non-Malignant Gastroduodenal Disorders

Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

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