Prevalence of HCV among the high risk groups in Khyber Pakhtunkhwa

Ali, Ijaz; Siddique, Lubna; Rehman, Latifur; Khan, Najib Ullah; Iqbal, Aqib; Munir, Iqbal; Rashid, Farzana; Khan, Sana Ullah; Attache, Safira; Swati, Zahoor Ahmad; Aslam, Mehwish S

doi:10.1186/1743-422x-8-296

Cited by 41 publications

(29 citation statements)

References 12 publications

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“…These findings were similar to other study which detected a high prevalence of (22.4%) anti-HCV seropositivity following dental surgery [23]. Similar studies conducted in Pakistan, Turkey, Morocco, and Italy had reported that dental procedure was one of the major risk factor for HCV transmission [1,4,11,24]. Moreover Ali et al, (2011) indicated that dental procedure is one of the major source of exposure for HCV transmission (39.7%) followed by injections (16.6%) and surgical procedures (16.6%) [24].…”

Section: Discussionsupporting

confidence: 80%

“…Similar studies conducted in Pakistan, Turkey, Morocco, and Italy had reported that dental procedure was one of the major risk factor for HCV transmission [1,4,11,24]. Moreover Ali et al, (2011) indicated that dental procedure is one of the major source of exposure for HCV transmission (39.7%) followed by injections (16.6%) and surgical procedures (16.6%) [24]. In contrast to our finding, several studies in Australia, Romania, Nigeria ,France ,Pakistan , and Iran found that dental procedures was not associated with anti-HCV positivity [10,[25][26][27].…”

Section: Discussionmentioning

confidence: 80%

“…Yildirim et al, (2005) showed a significant detection of HCV-RNA among Turkish HCV patients who underwent dental surgery (77.5%) compared to the control group (58.3%) [4]. Ali et al, (2011) in Khyber, Pakistan also found that the prevalence of anti-HCV and active HCV infection among individuals with dental surgery group was 14.28% [24]. Similarly, the women with dental extraction in our study were not only infected but they were also actively infective and thus could be a source of HCV infection.…”

Section: Discussionmentioning

confidence: 99%

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Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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Background: The medical risk factor associated with hepatitis C virus (HCV) infection such as blood transfusion and surgery had been intensely studied in many countries. Up to 40% of patients infected with HCV may have non identifiable routes of viral acquisition. Dental extraction may be one of these risk factors. The purpose of the present study was to determine the existence of infection and the predominated HCV genotype among subjects with dental extraction. Material and methods: A case-control study involving pregnant women with and without history of dental extraction (n=776, n=2715, respectively). HCV antibodies (anti-HCV) were tested using subsequently third generation enzyme immunoassay (EIA-3) and immunoblot assay (Lia Tek-111). In addition 94 serum samples were subjected to molecular analysis using RT-PCR and DNA enzyme immunoassay (DEIA) method for HCV-RNA and genotypes. Results: Anti-HCV seroprevelance was significantly higher (6.3%) among cases with dental extraction (cases) than their counter control group (control) (2.63%) (p=0.00001). Dental extraction act as a risk factor for HCV infection (OR=2.73; 95% CI=1.8-3.9). HCV-RNA was found to be significantly higher (74.6%) in cases than (38.7%) control group (p=0.0016). No significant association between HCV genotypic and the history of tooth extraction but HCV-1b showed higher rate (90%) among dental extraction cases. Conclusion: Our study showed that dental extraction acts as a risk factor for acquiring HCV. Complete sterilization and cleaning of equipment is necessary.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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“…4 A lot of studies among multi-transfused thalassaemia patients reported the prevalence of HCV in β-thalassaemia patients at a wide range of 3−67%. [5][6][7][8][9] Mean age, duration and mean amount of blood transfused have been associated with an increased risk of HCV infection in β-thalassaemia patients. A study in Dhaka Shishu (Children) Hospital showed that the prevalence of HCV infection in β-thalassaemia patients was 18.5%.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh

et al. 2018

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“…This can occur in patients with impaired immunity, which cannot generate a detectable level of anti HCV antibodies or in whom antibody production is delayed. HCV-RNA detection by a sensible method when anti HCV antibodies tests are negative, suggests an acute hepatitis C virus infection, especially when it is followed by anti HCV serum conversion [3] An estimated HCV prevalence of 3.9 million people was found in the United States with 2.7 million people found to have chronic infection with HCV (positive HCV RNA). Neither sex nor racial-ethnic group was found to be independently correlated with HCV infection [4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C Infection among Patients Undergoing Dialysis

Anwar

Imran

Shahzad

et al. 2016

JHVRV

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Hepatitis B and Hepatitis C are the major causes of morbidity and mortality in Pakistani population and their influence is considerable in patients suffering from kidney diseases and undergoing dialysis (Haemodialysis/ Peritoneal). This study considered the total number of dialysis a patient received and the number of dialysis in a week with the chances of Hepatitis C and Hepatitis B infection. This cross sectional study was conducted to determine the frequency of hepatitis B and hepatitis C in patients undergoing either haemodialysis or peritoneal dialysis. Serum sample was extracted from the blood of 60 patients. All the patients were suffering from either chronic kidney disease or acute renal failure. Screening was performed by strip method, which is based on Immunochromatographic technique for the detection of antibodies against HBsAg and HCV in patients on dialysis (haemodialysis/ peritoneal dialysis). The patients undergoing haemodialysis or peritoneal dialysis were randomly selected, out of which 43 were males and 17 were females. The association of HCV and HBV infection was calculated in relation to frequency per week of dialysis and total number of dialysis. There is significant correlation between HCV infection and total numbers of haemodialysis a patient has. Increase in the frequency of HCV infection was observed as the number of dialysis increased..

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Prevalence of HCV among the high risk groups in Khyber Pakhtunkhwa

Cited by 41 publications

References 12 publications

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh

Prevalence of Hepatitis B and Hepatitis C Infection among Patients Undergoing Dialysis

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