Prevalence of H. pylori Infection in Family Members of H. pylori Positive Patients and its Influence on the Reinfection Rate after Successful Eradication Therapy: A Two-Years Follow-up

Knippig, C.; Arand, F; Leodolter, Andreas; Nilius, M.; Bayerdörffer, Ekkehard; Klein, Ulf; Malfertheiner, P.

doi:10.1055/s-2002-32128

Cited by 26 publications

(26 citation statements)

References 10 publications

(23 reference statements)

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“…Conversely, the multi-colonization of members of the Moroccan family is in agreement with data reporting that multi-colonization is more frequent in countries in which H. pylori infection is highly prevalent [24]–[26], [37]. The relapse of the child-3 in family A shows that re-infection from a source independent of the family, a likely event in high prevalence developing countries [38], is also possible in developed countries.…”

Section: Discussionsupporting

confidence: 89%

Using Macro-Arrays to Study Routes of Infection of Helicobacter pylori in Three Families

Raymond

Thiberge²,

Kalach

et al. 2008

PLoS ONE

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BackgroundAnalysis of the evolutionary dynamics of Helicobacter pylori allowed tracing the spread of infection through populations on different continents but transmission pathways between individual humans have not been clearly described.Materials and MethodsTo investigate person-to-person transmission, we studied three families each including one child with persistence of symptoms after antibiotic treatment. Ten isolates from the antrum and corpus of stomach of each family member were analyzed both by sequencing of two housekeeping genes and macroarray tests.ResultsA total of 134 (8.4%) out of the 1590 coding sequences (CDSs) tested, including cag PAI and insertion sequences, were present in some but not all isolates (and are therefore defined as variable CDSs). Most of the variable CDSs encoded proteins of unknown function (76/134) or were selfish DNA including that encoding restriction/modification enzymes (13/134). Isolates colonizing the stomach of one individual can vary by point mutations, as seen in hspA, or by the gain or loss of one to five CDSs. They were considered as (genetic) variants. The phylogenetic clustering of gene profiles obtained on macro-arrays allowed identifying the different strains infecting families. Two to five strains circulated within a family. Identical strains were present in at least two members of all three families supporting the accepted model of intrafamilial transmission. Surprisingly, the mother was not implicated in the transmission of H. pylori in the two French families. Sibling-to-sibling transmission and acquisition of H. pylori from outside the family appeared to be probable in the transmission pathways.ConclusionMacroarray analysis based on previously selected CDSs gives a comprehensive view of the genome diversity of a pathogen. This approach combined with information on the origin of the hspA and glmM alleles revealed that Helicobacter pylori infection may be acquired by more diverse routes than previously expected.

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Section: Discussionsupporting

confidence: 89%

Using Macro-Arrays to Study Routes of Infection of Helicobacter pylori in Three Families

Raymond

Thiberge²,

Kalach

et al. 2008

PLoS ONE

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“…One reason may be that other studies did not look for peptic ulcer as a risk factor. 10, 23,29 Secondly, other studies that examined potential risk factors found few individuals who were reinfected, thus the power to demonstrate any possible associations with factors that were examined was weak. The mechanism of why peptic ulcer disease could be a risk factor for recurrence of H. pylori is unknown.…”

Section: Discussionmentioning

confidence: 99%

Reinfection after successful eradication of Helicobacter pylori: a 2‐year prospective study in Alaska Natives

McMahon

Bruce

Hennessy

et al. 2006

Aliment Pharmacol Ther

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“…In summary, reinfection with H pylori appears to occur at a similar rate as primary infection in the same population. Reinfection is no higher if family contacts are infected with H pylori than if they are not (15,16), and reinfection is not consistently higher in areas of high H pylori prevalence than in areas of low prevalence. Thus, reinfection of adults is unusual, even when there is considerable contact with infected hosts.…”

Section: Quel Est Le Taux Total De Réinfection à Helicobacter Pylori?mentioning

confidence: 91%

What is the Helicobacter pylori Global Reinfection Rate?

Parsonnet

2003

Canadian Journal of Gastroenterology and Hepatology

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Reinfection with any organism is related to the force of infection in the population and on both innate and acquired immunity to infection.Little is yet known about primary immune protection against Helicobacter pylori. Some data suggest that children can be recurrently infected, spontaneously eliminating the organism only to be infected again and again until the organism takes hold. This pattern of recurrent infection is not observed in patients who receive eradication therapy for chronic infection. After eradication of infection, the rate of reinfection is probably slightly lower than the primary infection rate in that age group, suggesting some level of acquired immunity. In developed countries, reinfection of adults in unusual, and recurrence usually repesents failure of primary eradicaton rather than new infection. Some cases of reinfection do occur, however. Given that acquired immunity probably varies little from population to population, reinfections will most likely occur in areas where the force of infecton is high, ie, where both the prevalence of infection and the opportunities for transmission are high.

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Prevalence of H. pylori Infection in Family Members of H. pylori Positive Patients and its Influence on the Reinfection Rate after Successful Eradication Therapy: A Two-Years Follow-up

Abstract: These results suggest that reinfection is not dependent on the H. pylori prevalence in family members and that H. pylori reinfection after successful eradication therapy is an unlikely event.

Cited by 26 publications

References 10 publications

Using Macro-Arrays to Study Routes of Infection of Helicobacter pylori in Three Families

Using Macro-Arrays to Study Routes of Infection of Helicobacter pylori in Three Families

Reinfection after successful eradication of Helicobacter pylori: a 2‐year prospective study in Alaska Natives

What is the Helicobacter pylori Global Reinfection Rate?

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