Prevalence of Glaucoma in the United States: The 2005–2008 National Health and Nutrition Examination Survey

Gupta, Priya; Zhao, Di; Güallar, Eliseo; Ko, Fang; Boland, Michael V.; Friedman, David S.

doi:10.1167/iovs.15-18469

Cited by 144 publications

(105 citation statements)

References 22 publications

(41 reference statements)

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“…The estimated prevalence of glaucoma in the US population, aged more than 40 years, is around 2.1% (approximately 2.9 million individuals) [6]. Approximately 90% of glaucoma are open angle glaucoma for which topical ophthalmic solutions are prescribed.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Timolol and Hospitalization for Symptomatic Bradycardia and Syncope: A Case Series

Abbas¹,

Hamadani²,

Ahmad³

et al. 2020

Cureus

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Topical beta-blockers are commonly used for the management of primary open angle glaucoma (POAG). One of the rare but serious side effects of the topical beta-blockers is bradycardia, defined as a heart rate below 60 beats per minute. In few cases, the heart rate drops to much lower level resulting in syncope or symptomatic bradycardia. Topical beta-blockers are still widely used for POAG even though there are much better medications available. We present a series of four cases of symptomatic bradycardia resulting from the use of timolol eye drops and after discontinuation of the eye drops, heart rate improved to normal range (60-100 beats per minute).

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Section: Discussionmentioning

confidence: 99%

Ophthalmic Timolol and Hospitalization for Symptomatic Bradycardia and Syncope: A Case Series

Abbas¹,

Hamadani²,

Ahmad³

et al. 2020

Cureus

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“…Сања Коцић 1,2 , Светлана Радевић 2 , Ивана Симић-Вукомановић 1,2 , Катарина Јанићијевић 2 , Мирјана Јанићијевић-Петровић 3,4 , Наташа Михаиловић 1…”

Section: сажетакunclassified

“…The prevalence of blindness in all types of the disease has been estimated at 5.2 million with three million cases with POAG. POAG is thus a complex and significant public health problem [4].…”

Section: Introductionmentioning

confidence: 99%

Hospitalization characteristics of patients with glaucoma in Central and West Serbia

et al. 2019

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Introduction/Objective Glaucoma is a chronic disease that impairs the optic nerve irreversibly and can lead to serious loss of vision and blindness. As the most frequent out of all, primary open-angle glaucoma has a worldwide incidence of 2.4 million. The objective of this article is to examine the characteristics of glaucoma hospitalization patterns in Central and West Serbia in the 2006-2017 period. Methods This study was a retrospective analysis of glaucoma hospitalizations in the Kragujevac Clinical Center from 2006 to 2017 (n = 1,751). All hospitalizations were divided according to discharge diagnoses into the following three subgroups: primary open-angle glaucoma, the primary closure glaucoma, and secondary glaucoma and other glaucoma types. Results The average hospitalization rate for glaucoma is 5/10,000 inhabitants. The lowest rate was recorded in 2013 (1.8/10,000) and the highest in 2015 (9.3/10,000). The rehospitalization rate ranged from 0.5/10,000 in 2013 to 6.9/10,000 in 2015, with an average of 2.4 patients per 10,000. The most common glaucoma was secondary glaucoma and other glaucoma types (44.6%), followed by primary open-angle glaucoma (37.9%) and primary closure glaucoma (17.5%). The average hospitalization length was 6.5 ± 4.9 days and it decreased from the average 9.7 ± 6.5 (2006) to 5.5 ± 3.7 days (2013) (p < 0.01) in all glaucoma types. Conclusion There was a significant reduction of the hospitalization length in all glaucoma types in Central and West Serbia. The hospitalization rates varied with a significant increase since 2013, which is the consequence of the increase in rehospitalization rates.

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“…Glaucoma affects nearly 60 million people worldwide and approximately 8 million people are blind from this disease [1]. In the US, more than 2.9 million people are afflicted with glaucoma [2].…”

Section: Introductionmentioning

confidence: 99%

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice

Nahomi

Nam

Rankenberg

et al. 2020

IJMS

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Background: Glaucoma is an optic neuropathy and involves the progressive degeneration of retinal ganglion cells (RGCs), which leads to blindness in patients. We investigated the role of the neuroprotective kynurenic acid (KYNA) in RGC death against retinal ischemia/reperfusion (I/R) injury. Methods: We injected KYNA intravenously or intravitreally to mice. We generated a knockout mouse strain of kynurenine 3-monooxygenase (KMO), an enzyme in the kynurenine pathway that produces neurotoxic 3-hydroxykynurenine. To test the effect of mild hyperglycemia on RGC protection, we used streptozotocin (STZ) induced diabetic mice. Retinal I/R injury was induced by increasing intraocular pressure for 60 min followed by reperfusion and RGC numbers were counted in the retinal flat mounts. Results: Intravenous or intravitreal administration of KYNA protected RGCs against I/R injury. The I/R injury caused a greater loss of RGCs in wild type than in KMO knockout mice. KMO knockout mice had mildly higher levels of fasting blood glucose than wild type mice. Diabetic mice showed significantly lower loss of RGCs when compared with non-diabetic mice subjected to I/R injury. Conclusion: Together, our study suggests that the absence of KMO protects RGCs against I/R injury, through mechanisms that likely involve higher levels of KYNA and glucose.

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Prevalence of Glaucoma in the United States: The 2005–2008 National Health and Nutrition Examination Survey

Cited by 144 publications

References 22 publications

Ophthalmic Timolol and Hospitalization for Symptomatic Bradycardia and Syncope: A Case Series

Ophthalmic Timolol and Hospitalization for Symptomatic Bradycardia and Syncope: A Case Series

Hospitalization characteristics of patients with glaucoma in Central and West Serbia

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice

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