Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis

Cioffi, Antonio; Cobelli, O. De; Veronesi, Paolo; Vecchia, Carlo La; Maisonneuve, Patrick; Corso, Giovanni

doi:10.3390/cancers15010306

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Moreover, the mutational spectrum within BRCA1/2 was mainly associated with an increasing risk of TNBC [38]. Thus, BRCA1/2 pathogenic variants (PVs) have been reported in many different populations [45], like Ashkenazi Jewish people, who are at higher BCR because of a high frequency of the BRCA1/2 gene mutations [46]. The results obtained by Bhaskaran et al (2019) suggest that the present Caucasian population-level BRCA mutation signature is insufficient to accurately reflect BRCA status in groups other than Caucasians, for instance, people who are Chinese [39].…”

Section: Genetics/genomics Of Breast Cancer Disparitiesmentioning

confidence: 99%

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

Neagu,

Bruno,

Johnson

et al. 2024

IJMS

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Precision oncology is based on deep knowledge of the molecular profile of tumors, allowing for more accurate and personalized therapy for specific groups of patients who are different in disease susceptibility as well as treatment response. Thus, onco-breastomics is able to discover novel biomarkers that have been found to have racial and ethnic differences, among other types of disparities such as chronological or biological age-, sex/gender- or environmental-related ones. Usually, evidence suggests that breast cancer (BC) disparities are due to ethnicity, aging rate, socioeconomic position, environmental or chemical exposures, psycho-social stressors, comorbidities, Western lifestyle, poverty and rurality, or organizational and health care system factors or access. The aim of this review was to deepen the understanding of BC-related disparities, mainly from a biomedical perspective, which includes genomic-based differences, disparities in breast tumor biology and developmental biology, differences in breast tumors’ immune and metabolic landscapes, ecological factors involved in these disparities as well as microbiomics- and metagenomics-based disparities in BC. We can conclude that onco-breastomics, in principle, based on genomics, proteomics, epigenomics, hormonomics, metabolomics and exposomics data, is able to characterize the multiple biological processes and molecular pathways involved in BC disparities, clarifying the differences in incidence, mortality and treatment response for different groups of BC patients.

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Section: Genetics/genomics Of Breast Cancer Disparitiesmentioning

confidence: 99%

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

Neagu,

Bruno,

Johnson

et al. 2024

IJMS

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Circum-Mediterranean influence in the Y-chromosome lineages associated with prostate cancer in Mexican men: A Converso heritage founder effect?

Álvarez-Topete,

Torres-Sánchez,

Hernández-Tobías

et al. 2024

PLoS ONE

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Prostate cancer is the second most common neoplasia amongst men worldwide. Hereditary susceptibility and ancestral heritage are well-established risk factors that explain the disparity trends across different ethnicities, populations, and regions even within the same country. The Y-chromosome has been considered a prototype biomarker for male health. African, European, Middle Eastern, and Hispanic ancestries exhibit the highest incidences of such neoplasia; Asians have the lowest rates. Nonetheless, the contribution of ancestry patterns has been scarcely explored among Latino males. The Mexican population has an extremely diverse genetic architecture where all the aforementioned ancestral backgrounds converge. Trans-ethnic research could illuminate the aetiology of prostate cancer, involving the migratory patterns, founder effects, and the ethnic contributions to its disparate incidence rates. The contribution of the ancestral heritage to prostate cancer risk were explored through a case-control study (152 cases and 372 controls) study in Mexican Mestizo males. Seventeen microsatellites were used to trace back the ancestral heritage using two Bayesian predictor methods. The lineage R1a seems to contribute to prostate cancer (ORadjusted:8.04, 95%CI:1.41–45.80) development, whereas E1b1a/E1b1b and GHIJ contributed to well-differentiated (Gleason ≤ 7), and late-onset prostate cancer. Meta-analyses reinforced our findings. The mentioned lineages exhibited a connection with the Middle Eastern and North African populations that enriched the patrilineal diversity to the southeast region of the Iberian Peninsula. This ancestral legacy arrived at the New World with the Spanish and Sephardim migrations. Our findings reinforced the contribution of family history and ethnic background to prostate cancer risk, although should be confirmed using a large sample size. Nonetheless, given its complex aetiology, in addition to the genetic component, the lifestyle and xenobiotic exposition could also influence the obtained results.

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Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 55 publications

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

Circum-Mediterranean influence in the Y-chromosome lineages associated with prostate cancer in Mexican men: A Converso heritage founder effect?

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