Prevalence of genotype‐specific human papillomavirus infection and cervical neoplasia in Taiwan: A community‐based survey of 10,602 women

Chen, Hui Chi; You, San–Lin; Hsieh, Ching-Liang; Schiffman, Mark; Lin, Ching Yu; Pan, Mei Hung; Chou, Yueh Ching; Liaw, Kai Li; Hsing, Ann W.; Chen, Chien Jen

doi:10.1002/ijc.25685

Cited by 31 publications

(29 citation statements)

References 41 publications

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“…High-risk infection accounted for 69.01% of cases and low-risk infection accounted for 17.33%; low-risk mixed with high-risk infections accounted for 13.66% of cases. HPV infection in Henan was significantly higher than in Zhejiang (13.3%) (Ye et al, 2010) and Taiwan (16.2%) (Chen et al, 2011), but is similar to that of Changchun (Liu et al, 2013), Hunan (Li et al, 2013), and Chaozhou in Guangdong (Chen et al, 2012), where the infection rates were 20.0, 22.6, and 24.5%, respectively, but below that of Guangxi (38.9%) (Li et al, 2012).…”

Section: Discussionmentioning

confidence: 67%

“…Rui et al (2012) reported that the main types of infection were HPV 16, 18, 58, 56, and 52 in East Asia; HPV 52,16,58,18,and 66 in Southeast Asia;and HPV 16,18,45,33,and 35 in South Asia (Bhatla et al, 2008). The main types of infection in France were HPV 16, 31, 33, 45, 52, and 58 (Monsonego et al, 2012); in Korea, HPV 16, 52, 58, 18, and 56 (Lee et al, 2012); and in Taiwan, HPV 52, 16, 56, and 18 (Chen et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We studied human papillomavirus (HPV) prevalence and genotype distribution among women in the Henan Province to provide epidemiological data as a means of preventing cervical cancer and developing a vaccine. A total of 14,873 samples were genotyped by using polymerase chain reaction reverse dot-blot. The overall HPVpositive rate in the sample was 23.98% (3566/14873), of which 69.01% (2461/3566) were infected with high-risk HPV types and 17.33% (618/3566) with low-risk types. Eighteen high-risk HPV types were detected; HPV 16 (16.73%) was the most common, followed by 58 (10.17%), 52 (9.11%), 56 (6.48%), 66 (5.76%), 33 (4.74%), 68 (3.92%), 31 (3.60%), 53 (3.13%), 59 (3.00%), 35 (2.53%), 51 (2.00%), 73 (1.08%), 45 (0.94%), 83 (0.84%), 39 (0.69%), 18 (0.61%), and MM4 (0.04%). Four low-risk HPV types were detected; HPV 43 (11.34%) was the most common, followed by 6 (5.17%), 42 (4.76%), and 11 (3.35%). 5452-5461 (2015) tions, of which 20.11% (717/3566) had double HPV infections. One peak in HPV prevalence occurred among women younger than age 25; a second peak occurred among women older than age 55. The overall prevalence of HPV infection in the Henan Province was 23.98%, of which the most common type was high-risk HPV and a single type of infection. The leading genotypes were HPV 16, 43, 58, 52, and 56.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

et al. 2015

Genet. Mol. Res.

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“…[5][6][7][8] In a previous report of our study, the prevalence of high-grade squamous intraepithelial lesion (HSIL) or worse lesions among participants with single-type infection of HPV 16, HPV 58 and HPV 52 at study entry was 31.9, 35.7 and 13.3%, respectively. 9 The participants infected with HPV 16, HPV 58 or HPV 52 had an increased prevalence of cervical cancer and carcinoma in situ (CIS).…”

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confidence: 99%

Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia

Chang

Chen

Lee³

et al. 2010

Intl Journal of Cancer

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Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of HPV 52 and 58 in Taiwan. A total of 11,923 women were enrolled from seven townships in [1991][1992]. HPV DNA in their cervical cells was detected and typed by EasyChip V R HPV blot. Among 424 participants infected with HPV 52 and/or 58, nucleotide variations were determined in cervical cell samples of 406 participants by the polymerase chain reaction sequencing of the long control region, E6 and E7 genes. Nonprototype-like variants including lineages B and C were detected in 278 (99.3%) of 280 HPV 52 samples. The prototype and prototype-like group (lineage A) of HPV58 was found in 132 (98.5%) of 134 HPV 58 samples, with sublineage A1, A2 and A3 variant in 14.2, 27.6 and 56.7%, respectively. Among women infected with single HPV 52 type, the C variant (vs. B variant) was associated with an increased prevalence of cytologically diagnosed high-grade squamous intraepithelial lesion or worse lesions showing an age-adjusted odds ratio (95% confidence interval, CI) of 5.2 (1.0-27.6) and an increased prevalence of histologically confirmed high-grade cervical intraepithelial neoplasia or more severe lesions with an age-adjusted odds ratio (95% CI) of 7.6 (1.3-43.8). It was concluded that frequency distributions of HPV 52 and 58 variants in Taiwan were different from those in European and American populations. The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation.Oncogenic human papillomavirus (HPV) is the major cause of cervical cancer. In addition to HPV 16 and 18, HPV 52 and 58 are also considered high-risk types for cervical intraepithelial lesions (CINs) and invasive carcinoma. 1,2 The unusually high prevalence of HPV 52 and 58 has been reported in Chinese populations living in China 3,4 and Taiwan. [5][6][7][8] In a previous report of our study, the prevalence of high-grade squamous intraepithelial lesion (HSIL) or worse lesions among participants with single-type infection of HPV 16, HPV 58 and HPV 52 at study entry was 31.9, 35.7 and 13.3%, respectively. 9 The participants infected with HPV 16, HPV 58 or HPV 52 had an increased prevalence of cervical cancer and carcinoma in situ (CIS).Intratypic HPV variants are characterized by the difference of less than 2% in nucleotide sequence from the prototypic L1 gene. 10 The genetic divergence among variants can differ by as much as 5% in the noncoding long control region (LCR). 11 But a study based on the complete genome analyses of HPV 16 showed that the E5-L2 intergenic region and the E4 and E5 genes are also hypervariable. 12 In a recent study, HPV variants can be classified based on their nucleotide sequence differences with most variants differing by <3%; type-specific variant lineages are defined based on a complete genome nucleotide sequence having >1% dissimilarity with the prototype and are named according to the phylogenetic tree topologies for each individual type. 13 Previous studie...

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“…[9][10][11] In our recent study, the prevalence of HPV types 16, 18, 52, and 58 were 1.4%, 1.4%, 1.9%, and 0.8%, respectively, among cytologically normal participants. 12 The persistent infection of specific oncogenic types of HPV has been documented as a predictor of cervical squamous intraepithelial lesions in longitudinal studies, but the definition of a persistent infection was very different in these studies. 13,14 Approximately 70% of HPV-infected women had a rapid clearance of infection by 12 months without any abnormal lesions.…”

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confidence: 99%

Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

Chuang

Chen

et al. 2011

Cancer

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BACKGROUND: Only a small proportion of women infected with human papillomavirus type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia. METHODS: Among 10,190 cytologically normal participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 viral load at study entry was examined by real-time polymerase chain reaction; persistent infection was defined as HPV18 infection at 2 consecutive examinations. RESULTS: There was a significant association between HLA-DRB1*0403 allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After adjustment for age and viral load at study entry, haplotype HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also associated with a significantly increased risk of high-grade squamous intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio (95% CI) of 18.1 (2.6-128.5). CONCLUSIONS: HLA-DRB1*0403 allele and HLA-DRB1*0405-DQA1*0301-DQB1*0302 haplotype may play important roles in determination of high viral load and persistent infection of HPV18 and subsequent cervical neoplasia risk.

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Prevalence of genotype‐specific human papillomavirus infection and cervical neoplasia in Taiwan: A community‐based survey of 10,602 women

Cited by 31 publications

References 41 publications

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia

Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

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