Prevalence of Genotype 3a Hepatitis C Virus (HCV) In the Infected Population of Lahore, Pakistan

Ijaz, Tayyaba; Shahzad, Muhammad Khurram; Sarfraz, Noeen; Khan, Muhammad Athar

doi:10.5455/ijavms.32

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Genotype 3 requires shorter duration of treatment as compared with genotype 1, with its associated reduced cost and side effects [ 33 ]. The predominance of HCV genotype 3 in our population confirmed the predominance of HCV genotype 3 in the surrounding countries including India [ 2 , 15 , 16 ], Iran [ 44 ], Bangladesh [ 14 , 15 ] and China [ 2 ].…”

Section: Discussionsupporting

confidence: 80%

“…Genetic heterogeneity is an outstanding feature of HCV and this may have important implications in diagnosis, pathogenesis, treatment, and vaccine development. The determination of HCV genotypes, subtypes and isolates has been helpful in understanding the evolution and the epidemiology of the HCV, and is an important factor in the pretreatment evaluation of patients [ 8 , 15 , 16 ]. The HCV genotypes show a distinctive geographical distribution [ 6 , 9 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus genotypes in Pakistan: a systemic review

Attaullah

Khan

Ali

2011

Virol J

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Background and aimPhylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. This article deepens the current molecular information about the geographical distribution of HCV genotypes and subgenotypes in population of four provinces of Pakistan. 34 published papers (1996-2011) related to prevalence of HCV genotypes/serotypes and subgenotypes in Pakistan were searched.ResultHCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus genotypes in Pakistan: a systemic review

Attaullah

Khan

Ali

2011

Virol J

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Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

Habib,

Anjum

et al. 2023

Infectious Medicine

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Diagnostically untypable hepatitis C virus variants: It is time to resolve the problem

Afzal¹

2014

WJG

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Pakistan is a low income country with more than 10 million hepatitis C virus (HCV) infections and the burden is on continuous raise. Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon therapy is genotype dependent. We observed at our diagnostic center that 15.6% of HCV patient's samples were not genotype-able by using Ohno et al method. The genotyped samples showed that 3a (68.3%) is the major prevalent genotype in Pakistan followed by 2a (10.3%), 3b (2.6%), 1b (1.5%), 2b (1.2%) and 1a (0.5%). Presence of large number of untypable HCV variants in the current study highlights an important issue of health care setup in Pakistan. Untypable HCV cases create difficulties in treatment of these patients. The problem of routine diagnostics setup of Pakistan should be addressed on priority basis to facilitate the medical professionals in patient's treatment and to help in achieving the maximum sustained virological response.

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Prevalence of Genotype 3a Hepatitis C Virus (HCV) In the Infected Population of Lahore, Pakistan

Cited by 3 publications

References 16 publications

Hepatitis C virus genotypes in Pakistan: a systemic review

Hepatitis C virus genotypes in Pakistan: a systemic review

Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

Diagnostically untypable hepatitis C virus variants: It is time to resolve the problem

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