Prevalence of GB virus type C/hepatitis G virus RNA and of anti‐E2 in individuals at high or low risk for blood‐borne or sexually transmitted viruses: evidence of sexual and parenteral transmission

Jj, Lefrére; Roudot‐Thoraval, Françoise; Morand‐Joubert, Laurence; Brossard, Y.; Parnet-Mathieu, F; Mariotti, Martine; Agis, F; Rouet, G; Lerable, Joëlle; Lefèvre, Guillaume; Girot, Robert; Loiseau, Pascale

doi:10.1046/j.1537-2995.1999.39199116899.x

Cited by 59 publications

(63 citation statements)

References 39 publications

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“…29 These results suggest parenteral transmission although other routes could not be excluded. 15,16,35 We observed a high prevalence of TTV infection, consistent with previous reports. 22,24 However, the prevalence of TTV in our population was lower than that reported for pregnant women in Congo.…”

Section: Discussionsupporting

confidence: 92%

“…15,40 The prevalence of GBV-C/HGV viremia in patients with sickle cell anemia (9.7%) was lower than that observed in other African polytransfused patients (e.g., South African hemophiliacs ϭ 23.8%.) 29 These results suggest parenteral transmission although other routes could not be excluded.…”

Section: Discussionmentioning

confidence: 85%

“…[10][11][12] Several investigations have demonstrated that GBV-C/HGV can be transmitted by blood products, 6,13 and a high prevalence (22% to 38%) of viral RNA has been reported for populations with parenteral risk. 14,15 However, a high prevalence of GBV-C/ HGV infection has also been observed in groups with little or no parenteral risk, such as blood donors. [13][14][15] Furthermore, despite several studies carried out in recent years, the role of GBV-C/HGV in pathogenesis is unclear.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 However, a high prevalence of GBV-C/ HGV infection has also been observed in groups with little or no parenteral risk, such as blood donors. [13][14][15] Furthermore, despite several studies carried out in recent years, the role of GBV-C/HGV in pathogenesis is unclear. 16,17 A new viral agent, the TT virus or TTV, has recently been isolated in Japan from the serum of a patient (TT) with posttransfusion hepatitis.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Tuveri¹,

Perret²,

Delaporte³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV antibodies. Among pregnant women, 29 of 229 (12.6%) were Hepatitis GB virus-C and Hepatitis G virus (GBV-C/ HGV) RNA positive (ϩ) and 32 of 81 (39.5%) anti-E2 ϩ versus 8 of 39 (20.5%) TTV DNA ϩ. Among sickle cell anemia patients, 9.7% (3/31) were GBV-C/HGV RNA ϩ versus 22.5% (7/31) TTV DNA ϩ. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n ϭ 27) versus controls (n ϭ 66) did not show significant differences for GBV-C/ HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n ϭ 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Tuveri¹,

Perret²,

Delaporte³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…Çoklu transfüzyon yapılanlar ile kan bileşenleri kullananlarda prevalansı sırasıyla %50 ve %7-%8 olarak bulunmuştur. Klinik anlam ve önemi henüz netlik kazanmamıştır (37,38) .…”

Section: Hepatit G Virüsü (Hgv)unclassified

Infectious Agents Transmitted by Blood and Blood Component and Impacts of Nükleik Asit Amplifikasyon Test (NAT)

Savasci¹,

Avcı²

2016

IKSST

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ÖZ Kan ve kan¸bileşenleri ile bulaşan enfeksiyonlar, özellikle viral hepatit virüsleri ve insan immün yetmezlik virüsü¸ (HIV), ABSTRACT Especially viral hepatitis viruses and human immunodeficiency virus (HIV) which are transmitted by the transfusion of blood and blood products have been an important public health problem for a long time in the world. Transfusion of blood and blood products is an ideal, easiest and a simplest route for transmission of infectious diseases. It is known that many infectious agents, either bacterial, viral, parasitic and fungal agents may be transmitted by the transfusion of blood and blood products. Nucleic Asit Amplification Test (NAT) provides additional layer of safety to the blood supply because it allows the detection of infectious agents during their incubation periods. Keywords: blood, blood center, infection, nucleic acid amplification test GİRİŞKan ve kan bileşenleri hayati tehlikeye neden olan birçok hastalık ve travmalarda tedavi amaçlı kullanı-lan bileşenlerdir. Kan ve kan bileşenlerinin tek kaynağının insan olması nedeniyle temini çok zor ve maliyet açısından oldukça pahalı bileşenlerdir. Kan naklinin güvenli bir şekilde yapılması, nakil sonrası ortaya çıkabilecek enfeksiyonların önlenebilmesine bağlıdır. Dünyada her yıl milyonlarca ünite kan ve kan bileşenleri kullanılmakta ve alıcıların bir kısmın-da transfüzyona bağlı enfeksiyonlar ortaya çıkmakta-dır. Kan ve kan bileşenlerinin kullanımı aracılığıyla bağışçıda mevcut enfeksiyon etkeninin alıcıya aktarılması tamamıyla engellenememektedir. Bu nedenle amaç, bu tip bulaşma risklerini "kabul edilebilecek kadar düşük" düzeylere indirgemek olmuştur (1) .Kan ve kan bileşenleri ile birçok enfeksiyon etkeni bulaşabilmektedir. Tarama testlerine rağmen neden enfeksiyon bulaşır sorusuna yanıt şu şekilde verilebilir. Transfüzyonla bulaşan enfeksiyon etkenlerinin dolaşımda uzun süre kalmaları, uzun inkübasyon süreleri, mutant suşların varlığı, asemptomatik klinikle seyretmeleri, kan ve kan bileşenlerinde stabilitelerini korumaları önemli özellikleridir. Enfeksiyon etkenleri arasında virüsler en önemli grubu oluştur-maktadır. En fazla sorun olan virüsler; hepatit B

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GBV-C/hepatitis G virus (HGV) RNA load in immunodeficient individuals and in immunocompetent individuals

et al. 1999

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The aim of this study was to establish the mean plasma GBV-C/hepatitis G virus (HGV) RNA load in groups of GBV-C/HGV-infected individuals with varied immune status and to determine the most frequent patterns of evolution of the plasma GBV-C/HGV RNA load over time during the natural history of infection. The mean plasma GBV-C/HGV RNA load observed was, from the lowest to the highest: 5.21 log in immunodepressed multiply-transfused patients, 6.45 log in HIV-positive individuals, 6.66 log in immunocompetent multiply-transfused patients, and 6.71 log in blood donors. The difference was significant between the four groups (P < 0.0001). The most frequent pattern of evolution of the plasma GBV-C/HGV RNA load was as follows: after the primary GBV-C/HGV infection, the viral load was elevated from the onset; then, a high, persistent and relatively steady viral RNA level was the rule; and when it occurred, the loss of viremia was not preceded by a decrease before recovery from GBV-C/HGV infection.

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Prevalence of GB virus type C/hepatitis G virus RNA and of anti‐E2 in individuals at high or low risk for blood‐borne or sexually transmitted viruses: evidence of sexual and parenteral transmission

Abstract: GBV-C/HGV is frequent in populations at risk for blood-borne or sexually transmitted viruses. GBV-C/HGV is not a hepatitis virus, and it seems appropriate to rename it.

Cited by 59 publications

References 39 publications

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Infectious Agents Transmitted by Blood and Blood Component and Impacts of Nükleik Asit Amplifikasyon Test (NAT)

GBV-C/hepatitis G virus (HGV) RNA load in immunodeficient individuals and in immunocompetent individuals

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