Prevalence of Gastroesophageal Reflux Symptoms in Asthma

Field, Stephen K.; Underwood, Margot; Brant, Rollin; Cowie, Robert L.

doi:10.1378/chest.109.2.316

Cited by 216 publications

(128 citation statements)

References 26 publications

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“…77,78 Reports of GERD-related symptoms in adults with asthma range from 65% to 77%. 61,[79][80][81] In a large case-controlled study, El-Serag et al 61 reported that EE and esophageal stricture were associated with chronic bronchitis, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchiectasis, and pneumonia, with odds ratios ranging from 1.15 to 1.50. In a recent 5-year follow-up of the original ProGERD study, the prevalence of asthma in GERD patients had increased from 4.5% at entry to 7.8% at the end of follow-up.…”

Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

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Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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“…However, this is a valid criterion and has been used in other studies, (24,25) in addition to the fact that this was not our main focus.…”

Section: Sgrq (Dependent Variable)mentioning

confidence: 99%

Controle da asma e qualidade de vida em pacientes com asma moderada ou grave

et al. 2011

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Objective: To evaluate the association between degree of asthma control and health-related quality of life in patients with moderate or severe asthma. Methods: This was a descriptive observational study involving 59 outpatients with moderate or severe asthma under treatment at the Asthma Outpatient Clinic of the Federal University of Ceará Walter Cantídio University Hospital, in the city of Fortaleza, Brazil. The patients were evaluated regarding sociodemographic and clinical characteristics, as well as spirometric parameters. The asthma control status was assessed using the asthma control test (ACT), and quality of life was assessed using the Saint George's Respiratory Questionnaire (SGRQ). Results: The mean age of the patients was 55.0 ± 12.4 years, and 76.3% were female. The ACT score showed statistically significant negative correlations with all SGRQ scores: total (r = −0.72); symptoms (r = −0.78); activity (r = −0.67); and impact (r = −0.68). Multiple regression analysis showed that the most robust predictive variables for SGRQ total score were ACT score (coefficient = −3.18; 95% CI: −4.14 to −2.23) and duration of disease (coefficient = −0.29; 95% CI: −0.54 to −0.03). The ACT score also explained the linear variation of the SGRQ domains: symptoms (coefficient = −3.41; 95% CI: −4.45 to −2.37); activity (coefficient = −3.07; 95% CI: −4.57 to −1.57); and impact (coefficient = −2.68; 95% CI: −3.71 to −1.65). Conclusions: The degree of asthma control appears to have a significant impact on health-related quality of life.Keywords: Asthma/prevention and control; Quality of life; Questionnaires. ResumoObjetivo: Avaliar a associação entre o estado de controle da asma e a qualidade de vida relacionada à saúde em pacientes com asma moderada ou grave. Métodos: Estudo descritivo observacional com 59 pacientes portadores de asma moderada ou grave, acompanhados no Ambulatório de Asma do Hospital Universitário Walter Cantídio da Universidade Federal do Ceará, em Fortaleza (CE). Os pacientes foram avaliados quanto a dados sociodemográficos, clínicos e espirométricos. O estado de controle da asma foi avaliado através do asthma control test (ACT) e a qualidade de vida através do Saint George's Respiratory Questionnaire (SGRQ). Resultados: A média de idade dos pacientes foi de 55,0 ± 12,4 anos, e 76,3% eram do sexo feminino. Foram observadas correlações negativas significantes entre os escores do ACT e todos os escores do SGRQ: total (r = −0,72); sintomas (r = −0,78); atividade (r = −0,67); e impactos (r = −0,68). A análise de regressão múltipla mostrou que o escore do SGRQ total teve como variáveis preditivas mais robustas o escore do ACT (coeficiente = −3,18; IC95%: −4,14 a −2,23) e tempo de doença (coeficiente = −0,29; IC95%: −0,54 a −0,03). O escore do ACT também explicou linearmente a variação do SGRQ em seus domínios: sintomas (coeficiente = −3,41 e IC95%: −4,45 a −2,37); atividade (coeficiente = −3,07 e IC95%: −4,57 a −1,57); e impactos (coeficiente = −2,68 e IC95%: −3,71 a −1,65). Conclusões: Na amostra estud...

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“…This large variation in GER prevalence reflects substantial differences in the standards applied for establishing the diagnosis of both asthma and GER and the frequency of silent GER (27). Twenty-five percent of asthmatic subjects with proven GER do not have the typical GER symptoms of heartburn and acid regurgitation (28).…”

Section: Gastroesophageal Refluxmentioning

confidence: 99%