Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

Abstract

Background/AimsGastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD. MethodsForty healthy subjects and 94 PDS type FD patients were enrolled in the study. The volunteers and patients ingested a radiolabeled (technetium-99m) solid test meal, and scintigraphic images were recorded. Gastric accommodation and emptying were assessed by scintigraphic imaging. The patients' dyspeptic symptoms were also explored using self-completed symptom questionnaires with 10 variables (4 scales, 0-3 points) at the same time. ResultsIn 94 Japanese FD patients, the prevalence of impaired gastric accommodation and delayed emptying were 14.9% (14/94) and 10.6% (10/94), respectively. Gastric motility abnormalities were seen in 25.5% (24/94) of FD patients. There was no association between gastric motility abnormalities and dyspeptic symptoms. ConclusionsGastric motility abnormalities were seen in 25.5% of Japanese PDS type FD patients. However, there was no association between gastric motility abnormalities and dyspeptic symptoms on gastric scintigraphy.

Duodenal low‐grade inflammation and expression of tight junction proteins in functional dyspepsia

“…Functional dyspepsia (FD) is a common disorder that is characterized by chronic or recurrent upper abdominal pain or discomfort without evidence of structural disease . Although the pathogenesis of FD remains largely unknown, various mechanisms such as genetic factors, impaired gastric motility, increased exposure of the duodenum to acid, visceral hypersensitivity, and altered brain‐gut duodenal axis interactions have been implicated . Low‐grade duodenal inflammation has recently been considered as a component of FD pathogenesis .…”

Investigation of Gastric Motility in Patients With the Overlap Syndrome of the Gastroesophageal Reflux Disease and Functional Dyspepsia

“…Так, в одной работе указывается на достоверно большую выраженность симптомов у больных ФД с нарушением аккомодации, чем у пациен-тов с нормальной аккомодацией [22]. В другой авторы пишут об отсутствии статистически значимых различий, отмечая лишь некоторую тенденцию к увеличению выраженности сим-птомов при нарушении аккомодации желудка у больных с ФД по сравнению с больными без таковых нарушений моторики проксимального отдела желудка [23].…”

“…В дистальном отделе желудка, напротив, наибольшие стати-стически значимые нарушения эвакуации те-стовой пищи были зарегистрированы у больных с ФД и синдромом перекреста ГЭРБ и ФД при сравнении с больными ГЭРБ. Нарушение эваку-ации содержимого желудка при ФД было также показано в исследованиях с использованием сцинтиграфии желудка [23], как и при использо-вании ультрасонографии для оценки моторики желудка в антральном [12] и фундальном отде-лах [22].…”

The Implication of Gastric Dysmotility in the Pathophysiology of Functional Dyspepsia

“…However, there are a few things to consider in the study by Asano et al 8 Test methods has a crucial impact on the results. The 2-hour gastric emptying time measurement may contribute to the relatively low prevalence of delayed gastric emptying, and scintigraphy was not optimal for evaluating gastric accommodation.…”

“…However, the prevalence of gastric dysmotility may be different among the populations. Asano et al 8 published in this edition of the Journal of Neurogastroenterology and Motility their own study that investigated the association between the prevalence of gastric motility abnormalities and gastrointestinal symptoms. Gastric emptying and accommodation were assessed by scintigraphic imaging and impaired in 14.9% and 10.6% of the study population, respectively.…”