Prevalence of Gastric and Duodenal Polyps and Risk Factors for Duodenal Neoplasm in Korean Patients with Familial Adenomatous Polyposis

Park, So Youn; Ryu, Ji Kon; Park, Ju Hee; Yoon, Hyuk; Kim, Ji Yeon; Yoon, Yong Bum; Park, Jae Gahb; Lee, Sang Hyub; Kang, Sung Bum; Park, Ji Won; Oh, Jae Hwan

doi:10.5009/gnl.2011.5.1.46

Cited by 41 publications

(30 citation statements)

References 32 publications

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“…Fundic gland polyps (FGPs) are the most common gastric tumours/polyps in FAP patients, and the frequency of FGPs ranges from 20 to 88% in FAP patients (9)(10)(11). Gastric adenoma is also common in FAP patients and develops in 9-50% of these patients (12)(13)(14)(15). Gastric cancer is more frequently found in Asian FAP patients than in Western FAP patients, which is similar to the corresponding rates in the general population.…”

Section: Introductionmentioning

confidence: 59%

Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients

Yamaguchi

Ishida

Ueno

et al. 2016

Jpn. J. Clin. Oncol.

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Objective: The upper gastrointestinal characteristics in Japanese familial adenomatous polyposis patients have not yet been clarified. The aim of the present study was to elucidate these characteristics in Japanese familial adenomatous polyposis patients. Methods: This study was conducted by the study group for familial adenomatous polyposis in the Japanese Society for Cancer of the Colon and Rectum. Familial adenomatous polyposis patients who underwent surgical resection from 2000 to 2012 were included in the study. Results: In total, 303 familial adenomatous polyposis patients were enrolled, with 265 cases of classical familial adenomatous polyposis (≥100 adenomas) and 38 cases of attenuated familial adenomatous polyposis (<100 adenomas). Fundic gland polyps were significantly more common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis; however, gastric cancer was significantly less common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis. Gastric cancer and duodenal adenoma were significantly more common in familial adenomatous polyposis patients with gastric adenoma than in those without gastric adenoma. Duodenal cancer was detected in 7 of 72 familial adenomatous polyposis patients with duodenal adenoma. The median tumour risk in 50-year-old familial adenomatous polyposis patients was 55.3, 21.8, 3.8, 39.2 and 7.7% for fundic gland polyp, gastric adenoma, gastric cancer, duodenal adenoma and duodenal cancer, respectively. Conclusions: Upper gastrointestinal tumours/polyps were frequently found in familial adenomatous polyposis patients, and their incidences were correlated; however, the frequency of gastric cancer in Japanese familial adenomatous polyposis patients was similar to that in the general population.

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Section: Introductionmentioning

confidence: 59%

Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients

Yamaguchi

Ishida

Ueno

et al. 2016

Jpn. J. Clin. Oncol.

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“…However, environmental and hereditary factors may also affect cancer incidence in FAP cohorts. For example, when compared to Western countries, the incidence of gastric and duodenal cancers has been reported to be higher and lower in Asia, respectively (18,34). Furthermore, length of follow-up, endoscopic techniques (use of side-viewing endoscopy, high resolution endoscopy, chromoendoscopy), strategies for prevention, frequent endoscopic resection of at risk lesions, ampullary localization have also been incriminated to influence incidence rates (23).…”

Section: Discussionmentioning

confidence: 99%

“…Local management of duodenal polyposis is associated with high rates of recurrence, although it may postpone cancer development. Thus, endoscopic or surgical management of patients diagnosed with large polyps, high-grade dysplasia or severe duodenal polyposis turned to be important preventive tools to decrease cancer deaths in FAP patients (1,18). Otherwise, patients diagnosed with duodenal cancer should undergo radical pancreaticoduodenectomy that may carry substantial morbidity and mortality rates (19,20).…”

Section: Introductionmentioning

confidence: 99%

Advanced duodenal neoplasia and carcinoma in familial adenomatous polyposis: outcomes of surgical management

Campos

Bustamante-Lopez

Kanno

et al. 2017

J. Gastrointest. Oncol.

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Background: In addition to the presence of neoplasia in the colon and rectum, patients with familial adenomatous polyposis (FAP) may develop numerous polyps and carcinoma within the upper gastrointestinal tract. Methods:The aim of the present paper was to review the incidence advanced duodenal polyposis or cancer and their surgical outcomes. A retrospective review of patients' records from our department was performed. respectively. Duodenal carcinomas occurred later (55.8 years) when compared to advanced adenomatosis (45.3 years). Three patients were diagnosed due to symptoms, while the others were detected under endoscopic surveillance. Age interval between FAP treatment and duodenal neoplasia diagnosis was 15.3 years . All but one patient underwent duodenopancreatectomy (DP). Two from the 7 patients undergoing DP died, one from pulmonary embolism 30 days after surgery and the other from recurrent T4N0 duodenal tumor. Thus, major operative morbidity and mortality were 12.5%. Conclusions:In this single-center Brazilian series of FAP patients: (I) advanced duodenal neoplasia or cancer requiring surgery occurred in 5.5% of patients; (II) when reaching the fifth decade of life, patients should be carefully evaluated to diagnose and treat early lesions; (III) in spite of the technical complexity of DP, operative morbidity is acceptable in experienced hands; and (IV) continuous surveillance is necessary during follow-up.

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“…no hubo casos de cáncer gástrico en el período evaluado. En series occidentales no se reporta una mayor incidencia de cáncer gástrico cuando se compara con la población general, mientras que en series de Japón y Corea 16 , se reporta una mayor incidencia de cáncer gástrico en los pacientes con PAF. Por lo anterior el seguimiento del tracto digestivo está marcado por la enfermedad duodenal más que por el desarrollo de pólipos gástricos.…”

Section: Discussionunclassified

Se Justifica El Seguimiento Después De Una Colectomía en Pacientes Con Poloposis Adenomatosa Familiar

et al. 2016

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the follow up after colectomy in patients with familial adenomatous polyposis is justified background: Patients with classic familial adenomatous polyposis syndrome (FAPc) have a germline mutation in the APC gene. The most common phenotypic expression is the presence of multiple colorectal adenomatous polyps (more than 100), with high probability developing colorrectal cancer (CRC) before the fifth decade of life. Prophylactic surgery (total colectomy or restorative proctocolectomy) reduces the risk of developing CRC. However, the risk of developing tumors in other organs remains present. Objetive: Analyze the frequency and type of tumors associated with classic familial adenomatous polyposis syndrome (FAPc) patients undergoing prophylactic colectomy. material and methods: Cohort study. From the registry of hereditary colorrectal cancer (CRC) at our institution, we identified patients with FAPc who underwent total colectomy with ileorrectal anastomosis (TC-IRA) or restorative proctocolectomy (RTPC), from 1999 to 2014. In the follow-up we analyzed related tumors and mortality. results: 27 patients, of whom 18 (66.7%) underwent TC-IRA and 9 (33.3%) underwent RTPC. At the time of surgery, 4 patients had CRC (15%) and 5 had extracolonic tumors (osteomas). In a mean follow-up of 49, 4 months (i: 2 y 178) the following lesions were diagnosed: digestive tract adenomas in 17 (63%) patients, of these 2 required a proctectomy and 3 resection of duodenal adenomas. Eight patients developed desmoid tumors (30%), and 3 of them underwent surgery. One patient had an extradigestive tumor (thyroid cancer) and only 8/27 (29.6%) did not develop other tumors. One patient died due to progression of his CCR. discussion: In this series it is confirmed that most patients will develop neoplasms FAPc after colectomy. conclusion: The removal of the colon and/or rectum is able to prevent the development of CRC. However, two thirds of the patients develop other tumors in which systematic surveillance allowed early detection and treatment.

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Prevalence of Gastric and Duodenal Polyps and Risk Factors for Duodenal Neoplasm in Korean Patients with Familial Adenomatous Polyposis

Cited by 41 publications

References 32 publications

Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients

Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients

Advanced duodenal neoplasia and carcinoma in familial adenomatous polyposis: outcomes of surgical management

Se Justifica El Seguimiento Después De Una Colectomía en Pacientes Con Poloposis Adenomatosa Familiar

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