Prevalence of GAD autoantibodies in Brazilian women with previous gestational diabetes

Ferraz, Tânia B.; Motta, Rosa S.; Capibaribe, Diego Moreira; Ferraz, Camila; Chacra, Antônio Roberto; Forti, Adriana Costa e; Dib, Sérgio Atala

doi:10.1016/j.diabres.2007.01.011

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…1), with some studies showing higher frequency in GDM [9, 21, 22, 30, 39], and other no differences [19, 33–35, 43, 44]. Also GADA titres have been reported higher in GDM women in some studies [9, 21, 22, 30, 31], with others showing no difference [33–37]. As for the frequency of IA-2A positivity, this ranges from 0 to 6.2% (Fig.…”

Section: Introductionmentioning

confidence: 99%

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

2019

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Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy, and it is associated with increased risk of morbidity in maternal-fetal outcomes. GDM is also associated with a higher risk to develop diabetes in the future. Diabetes-related autoantibodies (AABs) have been detected in a small percentage (usually less than 10%) of women with gestational diabetes. The prevalence in gestational diabetes of these autoimmune markers of type 1 diabetes (T1D) has been assessed in many studies, together with the risk of progression of AABs-positive GDM towards impaired glucose regulation (IFG or IGT) and overt diabetes after pregancy. The question whether it is necessary to test for T1D autoantibodies in all pregnancies with GDM is still debated. Here we examine the epidemiology of T1D autoantibodies in GDM, their clinical relevance in term of future risk of diabetes or impaired glucose regulation and in term of maternal-fetal outcomes, and discuss when it may be the most appropriate time to search for T1D autoantibodies in women with gestational diabetes.

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Section: Introductionmentioning

confidence: 99%

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

2019

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“…Others auto-antibodies such as GAD65 and IA-2 has been detected with higher frequency in patients with type 1 diabetes, before or at the onset of the disease; these markers, as well as ICA, seem to have a predictive value for the onset of the disease [28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 95%

Serological markers of autoimmunity in pregnant women with polycystic ovary syndrome: a pilot study

Pérez-Bravo

Carrasco

Echiburú

et al. 2010

Gynecological Endocrinology

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Diabetes related autoimmunity in gestational diabetes mellitus: Is it important?

Lapolla

Dalfrà

Fedele

2009

Nutrition, Metabolism and Cardiovascular Diseases

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Prevalence of GAD autoantibodies in Brazilian women with previous gestational diabetes

Cited by 5 publications

References 8 publications

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

Serological markers of autoimmunity in pregnant women with polycystic ovary syndrome: a pilot study

Diabetes related autoimmunity in gestational diabetes mellitus: Is it important?

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