Prevalence of G6PD deficiency in Iranian neonates with jaundice: a systematic review and meta-analysis

Javadi, Maryam; Deravi, Somayeh; Zarei, Shabnam; Mahdavi, Nader; Ranjbaran, Mehdi

doi:10.1080/14767058.2021.1895738

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…The overall prevalence of G6PD deficiency in Iranian newborns with jaundice is reported to be 7%. 28 Our results showed that although UDCA can be effective in reducing unconjugated hyperbilirubinemia, it may not be very useful for neonates with risk factors such as G6PD deficiency. One possible cause could be the jaundice mechanism in G6PD enzyme-deficient newborns.…”

Section: Discussionmentioning

confidence: 63%

Effects of Two Different Doses of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates with Glucose-6-phosphate Dehydrogenase Deficiency Treated with Phototherapy: A Randomized Controlled Trial

Farhadi

Keyhanian

Naderisorki

et al. 2023

Global Pediatric Health

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the causes of severe hyperbilirubinemia, prolonged jaundice, and bilirubin-induced encephalopathy in neonates. In a randomized controlled trial, we evaluated the effect of oral ursodeoxycholic acid (UDCA) on indirect hyperbilirubinemia in G6PD-deficient neonates requiring phototherapy. Intervention group I (N = 45; received phototherapy and 10 mg/kg/day UDCA), Intervention group II (N = 40; received phototherapy and 20 mg/kg/day UDCA), and a control group (N = 49; received phototherapy and placebo). Levels of total serum bilirubin (TSB) in all 3 groups decreased significantly over time ( P = .001) but the level of TSB at different hours after admission and the duration of phototherapy did not differ significantly between the 3 groups. After discharge, the 2 intervention groups had a significantly lower rate of readmission than the control group ( P = .001). No significant difference was observed between the 10 and 20 mg/kg/day groups. Further evaluation is recommended, especially in terms of the pharmacokinetics of UDCA in neonates. Trial registration number: IRCT20091201002801N4, prospectively registered on 2019-06-1

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Section: Discussionmentioning

confidence: 63%

Effects of Two Different Doses of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates with Glucose-6-phosphate Dehydrogenase Deficiency Treated with Phototherapy: A Randomized Controlled Trial

Farhadi

Keyhanian

Naderisorki

et al. 2023

Global Pediatric Health

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“…Our study found that the type and prevalence of neonatal diseases are closely related to gender, gestational age, patient sources, delivery methods, and birth weight. The prevalence of most diseases in males was higher than in females (22)(23)(24). The analysis indicated a statistically significant difference between the patient sources.…”

Section: Discussionmentioning

confidence: 82%

“…The results showed that the proportion of males and females in each gestational age group was similar in inborn/outborn newborns. It was worth noting that gender had significant effect on neonatal prevalence, with males had higher prevalence than females (22)(23)(24). This demonstrates that although males accounted for more resources, there was no gender bias in treatment and referral.…”

Section: Discussionmentioning

confidence: 88%

The Disease Spectrum and Influencing Factors of NICU in Xiangxi, Underdeveloped Area of China: A 9-Year Retrospective Study

et al. 2022

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ObjectiveInvestigation of the basic conditions and disease spectrum in neonatal intensive care unit (NICU) from 2012 to 2020, in the underdeveloped area of Xiangxi, China.MethodsAll newborns (N = 16,094) admitted to the NICU of a hospital in the Xiangxi area from 2012 to 2020 were selected for the retrospective study.ResultsThe average male/female ratio was 1.43:1, with 9,482 males and 6,612 females admitted to the NICU. The sample comprised 41.02% premature infants, and 56.52% had been delivered via cesarean delivery (CD). The most prevalent diseases diagnosed in the NICU were jaundice (22.01%), respiratory (18.45%) and neurological diseases (17.54%). Over the 9-year study window, the prevalence of jaundice and cardiovascular diseases increased, while respiratory and neurological diseases became less frequent. The prevalence of the remaining diseases remained unchanged. Prevalence of neonatal diseases is influenced by gender, patient sources, delivery methods, gestational age and birth weight (P < 0.05). The prevalence of neonatal diseases was significantly higher in males, infants born via CD, and in infants of lower gestational age and birth weight.ConclusionThe study contributes in-depth information about infant characteristics in an NICU in an undeveloped region of China. In the past 9 years, the average proportion of premature infants in the NICU decreased to 37.38% in 2020, but this figure remains higher than the Chinese national average of 26.2%. Similarly, the CD rate is higher than the Chinese average. The spectrum of neonatal diseases in the NICU in Xiangxi area is drawn, included jaundice, respiratory and neurological diseases, primarily. Through statistical analysis, it is found that the types and prevalence of neonatal diseases are closely related to different gender, gestational age, patient sources, delivery methods, and birth weight (P < 0.05). Newborns of specific gestational age, birth weight and delivery method should be considered “at-risk” and targeted in the formulation of preventive measures. There is a great need to improve the diagnosis and treatment of neonatal diseases—and perinatal health care in general—to ensure improved outcomes for newborns admitted to NICUs in underdeveloped regions.

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“…The general prevalence of G6PD was reported to be 7% in the Iranian newborn population (11) , as the rate for Indonesia (12) and Saudi Arabia (13) varied from 1.7% to 10.5%, respectively. Meanwhile, the prevalence rate of this deficiency was reported to be 22% in this study.…”

Section: Discussionmentioning

confidence: 99%

The effect of phototherapy on neonatal calcium and bilirubin levels: a comparison between patients with low and normal G6PD levels

Sheikh¹,

Ostad-Rahimi²

2023

Pediatr Med Rodz

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Introduction: Iran is among countries that report a higher prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency, ranging from 2.28% to 30.80%. This study aimed to estimate the general prevalence of G6PD deficiency in newborns with jaundice who were hospitalised in southeast Iran. Methods: This was a prospective study. A total of 100 newborns (boys and girls) with hyperbilirubinaemia, presented to Amir Al-Mo’menin Hospital in 2006 and 2007, were selected for the study. Age, gender, weight, time of jaundice, the maximum level of direct bilirubin, and the total level of bilirubin among the newborns were recorded, and the data were analysed by SPSS. Results: A total of 100 jaundice neonates, including 46 girls and 54 boys, were enrolled. Twenty-two percent of these patients, including 18 (82%) boys and 4 (18%) girls, showed low levels of G6PD. The overall mean bilirubin level was 15.45 ± 3.43 mg/dL among neonates with low G6PD levels, while it was 19.21 ± 3.34 mg/dL in patients with normal G6PD levels, which showed a significant difference (p < 0.05). Conclusion: The prevalence of G6PD deficiency in neonates with jaundice in our study was 22%, which was higher compared to other regions. We propose G6PD deficiency screening for the prevention of its complications. We also suggest assessing calcium levels following phototherapy, given the higher prevalence of hypocalcaemia.

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Prevalence of G6PD deficiency in Iranian neonates with jaundice: a systematic review and meta-analysis

Cited by 5 publications

References 16 publications

Effects of Two Different Doses of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates with Glucose-6-phosphate Dehydrogenase Deficiency Treated with Phototherapy: A Randomized Controlled Trial

Effects of Two Different Doses of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates with Glucose-6-phosphate Dehydrogenase Deficiency Treated with Phototherapy: A Randomized Controlled Trial

The Disease Spectrum and Influencing Factors of NICU in Xiangxi, Underdeveloped Area of China: A 9-Year Retrospective Study

The effect of phototherapy on neonatal calcium and bilirubin levels: a comparison between patients with low and normal G6PD levels

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