Prevalence of functional dependence in Chinese centenarians and its relationship with serum vitamin D status

Yao, Yao; Fu, Shihui; Shi, Qiuling; Zhang, Hao; Zhu, Qiao; Zhang, Fu; Luan, Fuxin; Zhao, Yali; He, Yao

doi:10.2147/cia.s182318

Cited by 10 publications

(7 citation statements)

References 48 publications

(55 reference statements)

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“…Items of the Barthel index are regarded as dependent if they are performed with any help from other people. In our previous study, the functional dependence of ADL of centenarians was 71.2% (46).…”

Section: The Barthel Index For Activities Of Daily Livingmentioning

confidence: 79%

Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians

Zhang

Zhao

et al. 2020

Front. Psychiatry

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Background: The Pittsburgh Sleep Quality Index (PSQI) is a widely used self-report questionnaire that measures general sleep quality in general populations. However, its psychometric properties have yet to be thoroughly examined in longevous persons. Objectives: This study aimed to explore the reliability, validity and factor structure of the Chinese-language version of the PSQI in community-dwelling centenarians. Methods: A total of 958 centenarians (mean age = 102.8 years; 81.8% females) recruited from 18 regions in Hainan, China, completed the PSQI scale. Cronbach's alpha coefficient was used to measure the internal consistency. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed to explore the validity and factor structure of the PSQI in this sample. Correlations between the global PSQI score and physical function, depression symptoms, self-reported health status and subjective wellbeing were used to assess divergent validity. Results: The Cronbach's a coefficient of the PSQI was 0.68, and it increased to 0.78 after two components (medication use and daytime dysfunction) were removed. The Spearman correlation coefficients of the PSQI score with each component were statistically significant (P<0.01). EFA yielded a two-factor structure model of the original PSQI-7 and a one-factor structure model of the simplified PSQI-5. The one-factor model with five components (c 2 /df =1.59, CFI=0.99, RMSEA=0.03) fit the data well and had good configural invariance across demographic characteristics (0.53< D c 2 <5.58, P>0.05). Conclusions: The original PSQI showed acceptable applicability in Chinese communitydwelling centenarians, and its psychometric characteristics moderately improved after

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Section: The Barthel Index For Activities Of Daily Livingmentioning

confidence: 79%

Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians

Zhang

Zhao

et al. 2020

Front. Psychiatry

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“…Therefore, the CHCCS provides a good model for investigating aging and longevity in community-dwelling centenarians. Our previous work suggested that the serum 25(OH)D level might be associated with activities of daily living, functional dependence, and symptoms of depression at baseline in participants in the CHCCS [ 27 , 28 , 29 ]. In the present study, we further demonstrated that not only the 25(OH)D level but also the PTH and β-CTX levels were associated with all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

Associations of Serum 25(OH)D, PTH, and β-CTX Levels with All-Cause Mortality in Chinese Community-Dwelling Centenarians

Wang

Cheng

et al. 2022

Nutrients

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This longitudinal cohort study explored the associations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and β-C-terminal telopeptide of type 1 collagen (β-CTX) levels with all-cause mortality in centenarians. The study included 952 centenarians (81.4% female). During a median follow-up of 32 months, 752 (78.9%) centenarians died. The estimated 1-year, 3-year, and 5-year survival rates were 80.0%, 45.7%, and 23.6%, respectively. The association of mortality with 25(OH)D was linear, whereas the associations with PTH and β-CTX were J-shaped, with a lower risk below the median levels. Compared with 25(OH)D of ≥30 ng/mL, 25(OH)D < 30 ng/mL was associated with increased mortality (HR 1.52, 95% CI 1.24–1.86, p < 0.001). Compared with PTH of ≤65 pg/mL, PTH > 65 pg/mL was associated with increased mortality (HR 1.30, 95% CI 1.08–1.56, p = 0.005). Compared with β-CTX of <0.55 ng/mL, β-CTX ≥ 0.55 ng/mL was associated with increased mortality (HR 1.30, 95% CI 1.10–1.54, p = 0.002). A higher β-CTX level (even in the clinical reference range of 0.55–1.01 ng/mL) was associated with increased mortality (HR 1.23, 95% CI 1.04–1.47, p = 0.018). Centenarians with 25(OH)D < 30 ng/mL, PTH > 65 pg/mL, and β-CTX ≥ 0.55 ng/mL had a 2.77-fold (95% CI 1.99–3.85, p < 0.001) increased risk of mortality when compared with those with 25(OH)D of >30 ng/mL, PTH < 65 pg/mL, and β-CTX < 0.55 ng/mL. Lower serum 25(OH)D and higher PTH and β-CTX were independently correlated with increased all-cause mortality in Chinese community-dwelling centenarians.

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“…The Barthel Index of activities of daily living has been widely used to evaluate the physical function of centenarians (21,38); the validity and reliability of this tool for use in the Chinese population of older people have been well-established (39). The Barthel Index consists of 10 items measuring a person's PADLs, such as grooming, feeding, dressing, bathing, toilet use, transferring from bed to chair, walking, stair climbing, bowel continence, and urinary continence.…”

Section: Physical Activities Of Daily Living (Padls)mentioning

confidence: 99%

“…Previous studies suggested that circulating 25-hydroxyvitamin D [25(OH)D], a major circulatory form of vitamin D (15), as an independent determinant for physical dependence (PD) (16)(17)(18)(19)(20) in older people, including centenarians (21). Pathophysiological mechanisms include its beneficial roles in skeletal muscle regeneration (22), arterial stiffness and endothelial function (23,24), and immune regulation (25) etc.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Zhang

Zhao

et al. 2020

Front. Immunol.

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Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function. It is hypothesized that serum complement components may interact with vitamin D in respect of the physical activities of daily living (PADLs). Objective: To investigate if serum complement components 3 (C3), complement components 4 (C4), and 25-hydroxyvitamin D [25(OH)D] associate with PADLs, and to examine whether the association between 25(OH)D levels and PADLs varies at different complement component levels among Chinese centenarians. Methods: This study was conducted in a group of population-based centenarians. PADLs were evaluated using the Barthel Index. Multiple regressions were used to analyze the associations among 25(OH)D, complements C3 and C4, and PADLs. Results: Among 943 participants, 672 (71.3%) had physical dependence (PD). After adjusting for potential confounders, serum 25(OH)D and C3 levels were positively correlated with PADLs, while C4 levels were negatively correlated with PADLs (Ps < 0.05). Serum 25(OH)D levels significantly interacted with both C3 (P for interaction = 0.033) and C4 (P for interaction = 0.006) levels on PADLs. At lower complement component levels, the multivariate odds ratios (ORs) of the upper tertile of vitamin D for PD were 0.32 (95% CI: 0.18-0.55) in the C3 group and 0.29 (95% CI: 0.16-0.50) in the C4 group. At higher complement component levels, the ORs in the C3 and C4 groups were not statistically significant. Zhang et al. Complement Component, 25(OH)D and PADLs Conclusions: In a group of population-based Chinese centenarians, we observed that serum complement C3 and 25(OH)D levels were positively associated with PADLs, while C4 was negatively associated with PADLs. The associations between 25(OH)D levels and PADLs were more pronounced in groups with lower serum complement component levels.

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Prevalence of functional dependence in Chinese centenarians and its relationship with serum vitamin D status

Cited by 10 publications

References 48 publications

Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians

Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians

Associations of Serum 25(OH)D, PTH, and β-CTX Levels with All-Cause Mortality in Chinese Community-Dwelling Centenarians

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

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