Prevalence of Frailty in the Middle East: Systematic Review and Meta-Analysis

Alqahtani, Bader A.; Alshehri, Mohammed M.; Elnaggar, Ragab K; Alsaad, Saad M; Alsayer, Ahmed A.; Almadani, Noura; Alhowimel, Ahmed; Alqahtani, Mohammed A.; Alenazi, Aqeel M.

doi:10.3390/healthcare10010108

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…While these changes occur in all individuals as they age, they are particularly pronounced in the frail [42]. A meta-analysis by Bader A A et al, involving nine observational studies, concluded that frailty prevalence is higher in Middle Eastern countries [43].…”

Section: Discussionmentioning

confidence: 99%

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

li,

Xie,

Tian

et al. 2023

Preprint

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Background Aging is an inevitable phenomenon of biological processes, and frailty, one of its key symptoms, usually reflects a decline in the body's functional and adaptive capacity. In this study, we aimed to investigate the association between frailty index (FI) and phenotypic age using quantitative measures. Herein, a cross-sectional study in a U.S. population reinforces current clinical knowledge that frailty promotes accelerated aging in phenotypic age. Methods In this cross-sectional study, data from the National Health and Nutrition Examination Survey (NHANES) were utilized, encompassing 11,918 participants aged 20 years and older. The analyses employed multiple logistic regression and restricted cubic splines (RCS). Additionally, subgroup analyses stratified by covariates were performed. Results This study included 11,918 adult participants with complete data. After adjusting for all confounding factors, a significant positive correlation was observed between FI and phenotypic age [2.04 (1.89, 2.18)], indicating that for every 0.1 increase in FI score, the phenotypic age increased by 2.04 years. Further subgroup analysis demonstrated that this association was significant only in some subgroups. Conclusion We observed a correlation between FI and the accelerated aging represented by phenotypic age. Our findings warrant further confirmation in future, more extensive prospective studies.

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Section: Discussionmentioning

confidence: 99%

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

li,

Xie,

Tian

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Studies were classified as poor [0–4], satisfactory [5–6], good [7–8], or very good [9–10]. Studies with minimal bias were given a maximum of five stars, and the total score ranged from 0 to 10 ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

The effect of penile traction device in men with Peyronie’s disease on penile curvature, penile length, and erectile dysfunction: a systematic review and meta-analysis

Almsaoud,

Safar,

Alshahrani

et al. 2023

Transl Androl Urol

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Background Peyronie’s disease (PD) results in curvature, pain, and erectile dysfunction (ED). Penile traction devices (PTDs) are a non-invasive treatment option for PD by applying mechanical forces to elicit biochemical responses that reduce curvature and improve penile function. In the present study, we systematically reviewed and analyzed the literature investigating the use of PTD to treat PD. Methods We have conducted electronic and manual search strategies within the databases and included articles to find relevant studies. A total of Five studies met all the predefined inclusion criteria and were selected for inclusion in the review. Outcomes assessed are penile length, penile curvature, and erectile function (EF). The study population consisted of patients with PD, the intervention was penile traction therapy (PTT), the comparison was matched placebo or follow-up, and the study design was randomized controlled trials (RCTs) or cohort studies. The Cochrane risk of bias assessed the studies’ quality for randomized studies and the Newcastle-Ottawa scale (NOS) for non-randomized observational studies. All statistical analyses were performed using R software. Results were considered statistically significant for P<0.05. Results Only five studies met inclusion and exclusion criteria and were published between 2014 and 2021. The sample sizes range [51–110], totaling 419, with a mean of 83.8 patients—the follow-up with a mean of 6.75 months. This meta-analysis evaluated the efficacy of PTD on curvature degree, penile length, and EF in patients. There is a significant positive effect on the curvature degree (P=0.0373), while there is no significant effect on penile length and EF (P=0.5315 and 0.1010), respectively. They are Indicating low heterogeneity with an estimated total heterogeneity of 0. Overall, the available evidence does not support the efficacy of the intervention for penile length or EF. Conclusions The current evidence suggests that PTDs can be a safe and effective treatment option for men with PD to reduce penile curvature. However, further research, including more RCTs with extended follow-up periods, is needed to fully understand their efficacy and determine the ideal timing and patient subtypes that would benefit from PTD.

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“…Although reliable estimations are difficult to obtain due to extreme variability in the methodological approach adopted in the different studies,[ 26 ] the distribution of the patterns above among the surgical population worldwide is widely influenced by social and economic factors, with higher concentration of disabilities in poorest countries. [ 27 28 ] A correlation between different age brackets and FS with the surgical outcome in the very elderly (aged more than 85 years) has been shown in a wide patients’ group. [ 29 ]…”

Section: Introductionmentioning

confidence: 99%

Geriatric anesthesia: Demographics, epidemiology, state of the art at international level, educational needs, and future perspectives

Bettelli

2023

Saudi J Anaesth

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Population aging has induced in the last year a corresponding aging inside the surgical population, currently accounting for 45%.50% of the total surgical population in the majority of the advanced countries. This has induced a number of new challenges in the daily anesthesia practice, ranging from the need of implementing specific education in the field of geriatric medicine, organizational adjustments aimed to adapt our preoperative evaluation methodology to the needs older patients present, and a careful redesign of the whole perioperative course for these patients. Today’s anesthesiologists are called to became familiar with the aging processes and their impact on the patho.physiological perioperative course, with the concept of functional impairment and frailty and with the dimensions of polypathology, polymedication, and reduced functional reserves. The introduction of new trends such as the team-based approach and interdisciplinary culture are essential to overcome these emerging criticalities.

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Prevalence of Frailty in the Middle East: Systematic Review and Meta-Analysis

Cited by 13 publications

References 31 publications

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

The effect of penile traction device in men with Peyronie’s disease on penile curvature, penile length, and erectile dysfunction: a systematic review and meta-analysis

Geriatric anesthesia: Demographics, epidemiology, state of the art at international level, educational needs, and future perspectives

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