Prevalence of four subtypes of mild cognitive impairment and APOE in a Japanese community

Sasaki, Megumi; Kodama, Chiine; Hidaka, Shin; Yamashita, Fumio; Kinoshita, Toru; Nemoto, Kiyotaka; Ikejima, Chiaki; Asada, Takashi

doi:10.1002/gps.2234

Cited by 45 publications

(33 citation statements)

References 28 publications

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“…Our results are in agreement with those studies that reported higher a prevalence of the ε4 allele in MCI, implying that MCI may have a greater genetic risk for the future development of AD [13], [48], [49]. However, different diagnostic criteria for MCI may have been applied in each of these studies, which may explain the differences observed in the estimates for the APOE genotypes between studies [50].…”

Section: Discussionsupporting

confidence: 91%

Frequency of the Apolipoprotein E ε4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study

Wang

et al. 2014

PLoS ONE

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ObjectivesTo describe the distribution of apolipoprotein E (APOE) genotypes among an elderly Chinese patient population with memory complaints treated in a memory clinic in Beijing and to compare the ε4 allele frequency among individuals with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and Alzheimer's disease (AD).MethodsA total of 385 subjects with memory complaints participated in the study, including 216 patients with AD, 56 with MCI, 17 with SCI, and 96 with other types of cognitive impairment. A total of 75 healthy elderly control subjects were also recruited. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to investigate the APOE genotypes.ResultsThe frequency of the ε4 allele was 19.6 percent for the entire sample of patients who had memory complaints. The APOE allele distribution differed between women and men (22.6% and 14.9%, respectively; p<0.05) in the individuals with memory complaints. Compared with the control group (7.3%), the prevalence of the APOE ε4 allele was significantly higher in the AD (23.6%) and MCI (21.4%) groups and was slightly increased in the SCI (14.7%) group.ConclusionsIn the memory clinic, we observed a higher prevalence of the APOE ε4 allele among Chinese AD and MCI patients. A similar trend was observed in patients with SCI. These findings suggest that nondemented APOE ε4 allele carriers with memory complaints may have a greater genetic risk for AD and should be monitored more closely.

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Section: Discussionsupporting

confidence: 91%

Frequency of the Apolipoprotein E ε4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study

Wang

et al. 2014

PLoS ONE

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“…Risk factors vary among MCI subtypes that may also affect brain activation during dual tasks. Individuals with aMCI also have a higher proportion of APOE4 (He et al 2009; Sasaki et al 2009) and risk of conversion to Alzheimer's disease (Palmer et al 2008), whereas naMCI has more vascular risk factors (Knopman et al 2009; Reitz et al 2007) and cortical infarcts (Kantarci et al 2008) than aMCI. There are different activation patterns during a memory task between MCI subtypes: compared to a control group, naMCI has diminished parietal and frontal activation during an encoding task, while aMCI has less activation in parietal, parietooccipital, insula and posterior temporal regions (Machulda et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Gray matter volume and dual-task gait performance in mild cognitive impairment

Doi

Blumen

Verghese

et al. 2016

Brain Imaging and Behavior

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Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.

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“…The prevalence of MCI in the general aging population (older than 65 years) has been reported to be 3.1% in the United States and 4.9% in Japan [28]–[29]. A systematic analysis of 22 studies in China described a pooled prevalence of MCI of 12.7% among older individuals [30].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictors of Mild Cognitive Impairment in Xi’an: A Community-Based Study among the Elders

Shang

Qian

et al. 2014

PLoS ONE

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Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive function and dementia among aging individuals. This study was designed to estimate the prevalence of MCI and explore the possible risk factors including gender disparities among community-dwelling older individuals. The study was conducted in Xi’an, China. This is a cross-sectional study. A total of 815 individuals, 60 years and older were selected by stratified random cluster sampling. Cognitive function was measured using the mini-mental status examination (MMSE), the Chinese version of the Dementia Rating Scales (CDRS) was used to apply the diagnostic of non-dementia, and activities of daily living (ADL) and instrumental activities of daily living (IADL) systems were used to functional status. The association between sociodemographic characteristics, lifestyle, history of chronic diseases and MCI were evaluated separately for men and women using the Pearson χ2- test and binary logistic regression. Of the 815 community-dwelling individuals, 145 were found to have MCI. Overall, the prevalence of MCI was 18.5%, with a prevalence of 19.6% in women (105/535), and 15.3% (40/261) in men. The results of the binary logistical regression analysis indicated that age and history of stroke were associated with MCI in men. For women, the risk factors were lower level of educational and lack of religious attendance. Results suggested that the factors capable of influencing MCI differed profoundly between older men and older women. For this reason, different preventative measures should be adopted to delay or reverse cognitive impairment among community-dwelling older men and women.

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Prevalence of four subtypes of mild cognitive impairment and APOE in a Japanese community

Cited by 45 publications

References 28 publications

Frequency of the Apolipoprotein E ε4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study

Frequency of the Apolipoprotein E ε4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study

Gray matter volume and dual-task gait performance in mild cognitive impairment

Prevalence and Predictors of Mild Cognitive Impairment in Xi’an: A Community-Based Study among the Elders

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