Prevalence of food-responsive enteropathy among dogs with chronic enteropathy in Japan

Kawano, Koji; Shimakura, Hidekatsu; Nagata, Noriyuki; Yuki, Masashi; Suto, Akemi; Suto, Yukinori; Uto, Shohei; Ueno, Hiromichi; Hasegawa, Toshifumi; Ushigusa, Takahiro; Nagai, Takashi; Arawatari, Yasunori; Miyaji, Kazuki; Ohmori, Kitaro; Mizuno, Takuya

doi:10.1292/jvms.15-0457

Cited by 15 publications

(21 citation statements)

References 10 publications

(18 reference statements)

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“…This study describes a population of dogs diagnosed with CE recruited at two universities in Australia. Similar to reports from other countries, a majority of dogs with CE were food‐responsive, despite having had previous dietary intervention . In our population, the second most frequent presentation of CE was ARE, and immunosuppressant treatment was needed in only two dogs.…”

Section: Discussionsupporting

confidence: 85%

“…However, of note is that two dogs with FRE in the present study were over nine years old and for this reason, a diet trial should be considered regardless of the age in dogs that are otherwise well. FRE dogs of similar age have also been previously reported …”

Section: Discussionmentioning

confidence: 60%

“…Another interesting aspect of the dogs with FRE is that many of them had undergone dietary trials prior to referral to the study institutions, yet still responded to an alternate diet. This mirrors the situation worldwide, where the majority of dogs with CE have been classified as FRE for over ten years in referral centres . A reason for the improved success after referral may be that clients willing to seek referral are more receptive to following a strict diet trial.…”

Section: Discussionmentioning

confidence: 69%

“…Interestingly, in a referral setting, several studies report that a majority of dogs respond to diet alone. This has been the case in North America, several European countries, and Japan, but to the best of our knowledge, no information is currently available in Australia . There is evidence that IBD in people is affected by geographical location, dietary intake, and genetic background .…”

Section: Introductionmentioning

confidence: 99%

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Treatment response and long term follow up in nineteen dogs diagnosed with chronic enteropathy in Australia

et al. 2019

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Chronic enteropathy (CE) in dogs is common worldwide, but little data is available from Australia. The aim of this study was to describe treatment response and long‐term outcome in a cohort of dogs with CE. Dogs were prospectively enrolled at Murdoch University and the University of Melbourne. After diagnostic investigation to rule out diseases other than CE, dogs underwent sequential therapeutic trials until achieving a clinical response (diet then antibiotics, and finally immunosuppressants). Success was defined as 75% reduction of clinical severity for a minimum of five weeks. A total of 21 dogs were enrolled, and 19 completed the study. One dog was euthanised for lack of response to treatment and one excluded for lack of owner compliance. Most dogs responded to diet (n = 10), followed by antibiotics (n = 7) and immunosuppressants (n = 2). Long‐term remission (median 21.1 months, [3.0‐44.7]) was achieved in eight out of ten dietary responders without additional treatment. In contrast, only two dogs with antibiotic response remained in long‐term remission, of which one needed on‐going antibiotic treatment. Longer term remission was achieved in the two dogs treated with immunosuppressants with on‐going low dose therapy. This study concludes that most dogs referred for CE in Australia respond to dietary treatment (even after previous dietary interventions), and remission is long‐term compared to dogs treated with an antibiotic. Furthermore, the need for long‐term antibiotics in some dogs to maintain response may lead to antibiotic resistance. This study supports adequate dietary trials for CE in dogs, and a need for alternative second‐line treatments.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Treatment response and long term follow up in nineteen dogs diagnosed with chronic enteropathy in Australia

et al. 2019

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“…Disease‐independent clinical scoring systems have been established in dogs8, 9 and can be used to semi‐objectively assess the severity of clinical signs at the time of diagnosis and to monitor patient improvement during treatment. Histopathologic and routine clinicopathologic findings usually are not able to distinguish different subgroups of CIE,5, 10 but younger dogs with less severe clinical signs are more likely to be diagnosed with FRE 5, 9. Treatment trials often are lengthy and further diagnostic tests, after appropriately designed dietary and antibiotic trials have failed, are usually invasive 3, 4, 5, 6.…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Heilmann

Steiner

2018

Veterinary Internal Medicne

108

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Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food‐responsive, antibiotic‐responsive, or immunosuppressant‐responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein‐losing enteropathy. Disease‐independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment. Histopathologic and routine clinicopathologic findings are usually not able to distinguish the subgroups of CIE. Treatment trials are often lengthy and further diagnostic tests are usually at least minimally invasive. Biomarkers that can aid in defining the presence of disease, site of origin, severity of the disease process, response to treatment, or a combination of these would be clinically useful in dogs with CIE. This article summarizes the following biomarkers that have been evaluated in dogs with CIE during the last decade, and critically evaluates their potential clinical utility in dogs with CIE: functional biomarkers (cobalamin, methylmalonic acid, folate, α1‐proteinase inhibitor, immunoglobulin A), biochemical biomarkers (C‐reactive protein, perinuclear anti‐neutrophilic cytoplasmic antibodies, 3‐bromotyrosine, N‐methylhistamine, calprotectin, S100A12, soluble receptor of advanced glycation end products, cytokines and chemokines, alkaline phosphatase), microbiomic biomarkers (microbiome changes, dysbiosis index), metabolomic biomarkers (serum metabolome), genetic biomarkers (genomic markers, gene expression changes), and cellular biomarkers (regulatory T cells). In addition, important performance criteria of diagnostic tests are briefly reviewed.

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Localized intestinal cryptococcosis and co‐parasitism in a juvenile dog

Jones

Cridge

2022

Vet Record Case Reports

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An 8.5-month-old, male, entire golden retriever presented for 6-month history of large bowel diarrhoea and vomiting. Giardiasis was previously treated. Clinical signs recurred despite empirical antibiotics, food trials, probiotics and psyllium. Physical exam revealed circumferential cobblestone-like rectal mucosa. Rectal scrape cytology was consistent with cryptococcosis. Latex cryptococcal agglutination test was consistently negative. Thoracic radiographs were normal. Notable abdominal ultrasound findings included jejunal and suspected mesenteric cystic lymphadenopathy and multifocal areas of submucosal thickening. Abdominal lymph node aspirates revealed lymphoid hyperplasia. Faecal sedimentation and floatation revealed few Alaria species eggs and many Coccidia oocysts, respectively. Patient was treated with fluconazole, sulfadimethoxine, Drontal Plus and subsequently developed pancytopenia secondary to sulphonamide therapy requiring hospitalization, and recovered with supportive care and discontinuation of drug. Patient's clinical signs, rectal palpation and sonographic features resolved with continued fluconazole therapy. This case demonstrates localized intestinal cryptococcosis based on cytology with negative latex cryptococcal agglutination test and pancytopenia secondary to sulphonamide therapy for co-parasitism.

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Prevalence of food-responsive enteropathy among dogs with chronic enteropathy in Japan

Cited by 15 publications

References 10 publications

Treatment response and long term follow up in nineteen dogs diagnosed with chronic enteropathy in Australia

Treatment response and long term follow up in nineteen dogs diagnosed with chronic enteropathy in Australia

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Localized intestinal cryptococcosis and co‐parasitism in a juvenile dog

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