Prevalence of Factor V Leiden in Young Adults with Retinal Vein Occlusion

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

“…The risk of thrombosis is increased five to tenfold in heterozygotes and 50-100 fold in homozygotes (Majerus 1994;Rosendaal et al 1995;Dahlback et al 1996). We have previously shown that this mutation is overrepresented in young patients with central retinal vein occlusion (Larsson et al 1996), whereas others have not been able to confirm these results (Gottlieb et al 1998;Linna et al 1997).…”

Factor V Leiden and prothrombin 20210 A mutations in patients with central and branch retinal vein occlusion

“…There are only a limited number of studies which have investigated the role of factor V Leiden in branch retinal vein thrombosis. Demirci and Linna have studied factor V Leiden mutation only in young patients with branch retinal vein occlusion (Demirci et al 1997;Linna et al 1997). We think that this approach might have underestimated the role of factor V Leiden in BRVO as it is possible that this mutation may contribute to the development of thrombosis only in the presence of other risk factors such as hypertension or hypercholesterolemia which are clearly more frequent in the elderly population.…”

Central retinal vein occlusion and thrombophilia

“…20 Six studies have investigated the role of APCR/FVL in hemispheric and retinal branch occlusion. 18,25,[30][31][32][33]35 Although patients with this thrombophilic tendency were identified, the incidence compared to the normal population was not increased (in studies where a direct comparison was made).…”

“…17,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Although many studies suggest an increased frequency of APCR/FVL in patients with CRVO only two out of nine studies in which the incidence of APCR/FVL is compared with a normal cohort is there a significantly increased incidence of this abnormality. Surprisingly both of these studies included patients of any age where one would have anticipated an association with younger patients.…”