Prevalence of extended-spectrum β-lactamase-producing Escherichia coli in a tertiary care hospital in Tehran, Iran

Mehrgan, Hadi; Rahbar, Mohammad

doi:10.1016/j.ijantimicag.2007.09.008

Cited by 67 publications

(58 citation statements)

References 15 publications

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“…Although there are several mechanisms for the development of resistance, mutation in the gyrA gene is the most common. 16 The high occurrence of ciprofloxacin resistance (75.9%) in our isolates is in accordance with some other reports from Asia, 15,17 but it is in contrast to a report from Vietnam. 18 As expected, the incidence of resistance to nalidixic acid, which is a simple quinolone, was higher (93.1%) and in agreement with some earlier reports.…”

Section: Discussionsupporting

confidence: 92%

A profile of drug resistance genes and integrons in E. coli causing surgical wound infections in the Faisalabad region of Pakistan

et al. 2009

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Escherichia coli are one of the leading causes of infection in wounds. Emerging multiple drug resistance among E. coli poses a serious challenge to antimicrobial therapy for wounds. This study was conducted to ascertain a baseline profile of antimicrobial resistance in E. coli isolates infecting surgical wounds. A total of 64 pus samples from hospitalized patients were screened and 29 (45.3%) were found to have E. coli, which were identified biochemically and confirmed by molecular methods. Using the disc diffusion method, antimicrobial resistance was observed toward tetracycline (100%), cefradine (100%), nalidixic acid (93.1%), ampicillin (86.2%), gentamicin (86.2%), cefixime (82.8%), ceftriaxone (82.8%), aztreonam (82.8%), ciprofloxacin (75.9%), streptomycin (72.4%), cefoperazone (65.5%), chloramphenicol (58.6%) and amikacin (58.6%). In an effort to find relevant genes, 11 different genes were targeted by PCR. Among these, the mutated gyrA gene was found to be the most prevalent (82.8%), followed by the TEM (72.4%), catP (68.9%), catA1 (68.9%), tetB (62.1%), blt (58.6%), bla CTXÀMÀ15 (27.6%), bla TEM (20.7%), bla OXA (17.2%), tetA (17.2%) and aadA1 (13.8%) genes. The presence of integrons was also studied among these isolates. The prevalence of class 1 integrons was the highest (44.8%), followed by class 2 (27.6%). Three (10.3%) isolates carried both class 1 and class 2 integrons (first report from E. coli infecting wounds). The high incidence of integrons points toward their facilitation for carriage of antimicrobial resistance genes; however, in nearly 37% isolates, no integrons were detected, indicating the significance of alternative mechanisms of gene transfer. Another salient finding was that all isolates were multidrug-resistant E. coli.

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Section: Discussionsupporting

confidence: 92%

A profile of drug resistance genes and integrons in E. coli causing surgical wound infections in the Faisalabad region of Pakistan

et al. 2009

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“…Similar to these results, in some previous studies conducted in Tehran and other areas of Iran, a high rate of ESBL among Enterobacteriaceae was revealed. [13][14][15] Recent publications have uncovered the predominant interference of bla CTXM1 in ESBL positive isolates all over the world. In the present study, bla CTXM1 group was accounted for 26% of blood ESBL production.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility Profile, ESBL Production and blaCTX-M1, blaSHV and blaTEM Types Among Escherichia coli Blood Isolates

Nojoomi¹,

Ghasemian²,

Eslami³

et al. 2016

Int J Enteric Pathog

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“…Patients were approximately the same gender and age as described in other studies concerning ESBL producing Enterobacteriaceae infection with male patients around 60 years of age (Kassakian & Mermel, 2014;Mehrgan & Rahbar, 2008).…”

Section: Discussionmentioning

confidence: 99%

Higher CTX-M, Tem, and SHV Extended-Spectrum Beta-Lactamase Plasmid Gene Combination Frequency in Esbl Producing Klebsiella Pneumoniae Compared With Esbl Producing Escherichia Coli

Skuja

Pekarska

Derovs

et al. 2016

CBUP

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Prevalence of extended-spectrum β-lactamase-producing Escherichia coli in a tertiary care hospital in Tehran, Iran

Cited by 67 publications

References 15 publications

A profile of drug resistance genes and integrons in E. coli causing surgical wound infections in the Faisalabad region of Pakistan

A profile of drug resistance genes and integrons in E. coli causing surgical wound infections in the Faisalabad region of Pakistan

Antibiotic Susceptibility Profile, ESBL Production and blaCTX-M1, blaSHV and blaTEM Types Among Escherichia coli Blood Isolates

Higher CTX-M, Tem, and SHV Extended-Spectrum Beta-Lactamase Plasmid Gene Combination Frequency in Esbl Producing Klebsiella Pneumoniae Compared With Esbl Producing Escherichia Coli

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