Prevalence of extended-spectrum β-lactamase-producing bacteria in hospital and community sewage in Saudi Arabia

Basode, Vinod Kumar

doi:10.1016/j.ajic.2015.06.002

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…In a study conducted in an urban and rural hospital in central India, Chandran et al reported a very high prevalence of ESBL-producing E. coli in the hospital wastewater (96%) [ 31 ]. In our study, the prevalence was around 40%, lower than the aforementioned study but relatively higher than the figures reported by Diwan et al (25%), Abdulhaq et al (25%), and Korzeniewska et al (37%) [ 22 , 32 , 33 ]. Among genes coding for ESBL production, TEM and CTX-M are the most common [ 34 ].…”

Section: Discussioncontrasting

confidence: 75%

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Lien

Lan

Chúc

et al. 2017

IJERPH

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The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in Escherichia coli isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing. Extended-spectrum beta-lactamase (ESBL) production was tested using combined disk diffusion. ARGs were detected by polymerase chain reactions. Resistance to at least one antibiotic was detected in 83% of isolates; multidrug resistance was found in 32%. The highest resistance prevalence was found for co-trimoxazole (70%) and the lowest for imipenem (1%). Forty-three percent of isolates were ESBL-producing, with the blaTEM gene being more common than blaCTX-M. Co-harbouring of the blaCTX-M, blaTEM and qepA genes was found in 46% of isolates resistant to ciprofloxacin. The large presence of antibiotic-resistant E. coli isolates combined with ARGs in hospital wastewater, even post-treatment, poses a threat to public health. It highlights the need to develop effective processes for hospital wastewater treatment plants to eliminate antibiotic resistant bacteria and ARGs.

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Section: Discussioncontrasting

confidence: 75%

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Lien

Lan

Chúc

et al. 2017

IJERPH

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“…Tigecycline non-susceptible Klebsiella pneumoniae were recently isolated from heavily polluted coastal waters in Brazil [ 30 ] and less recently from hospital sewage in Saudi Arabia [ 31 ]. Other resistant Enterobacteriaceae could be recovered from drinking water samples in India [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water

Hladicz

Kittinger

Zarfel

2017

IJERPH

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Antibiotic-resistant bacteria are spreading worldwide in medical settings but also in the environment. These resistant bacteria illustrate a major health problem in our times, and last-line antibiotics such as tigecycline represent an ultimate therapy option. Reports on tigecycline non-susceptible Enterobacteriaceae are presented with regard to medical settings but are rare with that for the environment. The aim of this study was to characterize two tigecycline non-susceptible Klebsiella pneumoniae isolates from the river Mur, and to question the resistance mechanism. The screening for chromosomal mutations revealed a deletion and a silent point mutation in one isolate and a point mutation in the other isolate all within the ramR allele. RamR acts as repressor and prevents overexpression of ramA. These mutations are likely to cause a resistant phenotype due to the overexpression of AcrAB-TolC. MLST revealed that the isolates belonged to two unrelated MLST types (ST2392 and ST2394). Both isolates only revealed resistance to tigecycline and tetracycline. This is one of the rare reports of tigecycline-resistant Klebsiella pneumoniae from surface water. The presence of two genetically different isolates suggests that the river water may bear substances that favor mutations that can lead to this efflux pump-driven resistance.

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“…Apart from this, use of animal feed additives such as antibiotics plays a significant role in evolving antibiotic resistance in the normal flora of animal gastrointestinal tracts [ 13 ]. Recent report states antibiotic-resistant bacteria have begun spreading into the environment and communities [ 14 ]. The prevalence of vancomycin-resistance genes, a methicillin-resistance gene and a carbapenem-resistance gene has been reported in sewages of various countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewage in a southwestern province of Saudi Arabia

et al. 2018

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ObjectiveAccording to the World Health Organization, the increasing antibiotic resistance of pathogens is one of the most important threats to human health. Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewages will be potential threat to public health.ResultsVancomycin-resistance genes were detected in the sewage of community tank-II, sewage tank of the tertiary and general hospital. Carbapenem-resistance gene was detected in sewage of community tank-II and sewage from tertiary hospital. Methicillin-resistance gene was detected in sewage of community tank-II, sewage from a fish market sewage tank and sewage from an animal slaughter house sewage tank. The detection of a KPC, van A/B and a mecA in sewages will help further the process to take the appropriate measures to prevent the spread of such bacteria in the environment.

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Prevalence of extended-spectrum β-lactamase-producing bacteria in hospital and community sewage in Saudi Arabia

Cited by 4 publications

References 9 publications

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water

Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewage in a southwestern province of Saudi Arabia

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