Prevalence of Escherichia coli Pathotypes Among Children With Diarrhea in Babol, Northern Iran

Moshtagian, Fatemah; Alipour, Majid; Yahyapour, Yousef

doi:10.17795/ijep36326

Cited by 1 publication

(2 citation statements)

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“…The prevalence of diarrheagenic E. coli strains in this study is similar to some countries such as Colombia (14.4%) and is comparable with the other reports from India (26%), Iran (34%), USA (5.5% and 19%), etc. [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…In this research, some STEC strains (less than 10%) carried eae gene, which were identi ed as EHEC pathotypes. Reports from EHECs in Iran is rare [17,25], while annually, more than 70,000 cases of EHEC infections transmitted to human by the routes of foodborne, person-to-person, waterborne, animal contact and laboratory-related are recorded in the USA by Centers for Disease Control and Prevention (CDC) [26].…”

Section: Discussionmentioning

confidence: 99%

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The Emergence of Extended-Spectrum β-Lactamase Producing and Hybrid Pathotypes of Escherichia Coli Isolates from Diarrheic Human Cases: A New Public Health Concern in Iran

Asadi¹,

Ghanbarpour²,

Kalantar-Neyestanaki³

et al. 2021

Preprint

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Background: Intra-intestinal pathogenic strains of Escherichia coli are responsible for mild to severe gastrointestinal lesions, which are mediated by various virulence factors. In this study, we have focused on a comprehensive set of E. coli pathotypes, including STEC, EPEC, EHEC, ETEC, and some hybrid pathotypes including, STEC/ ETEC, EHEC/ ETEC, and EPEC/ ETEC.Methods: Totally, 467 stool samples were obtained from gastrointestinal patients during four years (2016 to 2020). Four pathotypes of E. coli (EPEC, ETEC, EHEC, STEC) were screened due to six virulence genes, including eae, stx1, stx2, st, and lt using the conventional PCR method. Finally, detected E. coli pathotypes were subjected to determine phenotypic and genotypic β-lactam resistance properties.Result: In this study 59/467 (12.63%) strains belonged four pathotypes including STEC (20/59; 50.8%), EPEC (11/59; 18.6%), ETEC (8/59 13.5%), EHEC (5/59; 8.4%) and three novel hybrid pathotypes including STEC/ETEC (3/59; 5%), EHEC/ETEC (1/59; 1.6%), and EPEC/ETEC (1/59; 1.6%). Totally 23/59 (38.9%) isolates were identified as ESBL-producing. Conclusion: Transmission of virulence and antibiotic resistance genes among E. coli strains lead to the emergence of antimicrobial-resistant hybrid pathogenic strains, which is an important health concern. According to food-born and fecal-oral transmission of these E. coli strains, standard methods should be performed to eliminate the possible contamination of food, equipment, and living environment to manure and feces.

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