PREVALENCE OF ESBL PRODUCERS IN FAMILY ENTEROBACTERIACEAE ISOLATED FROM D. Y. PATIL MEDICAL COLLEGE &amp; HOSPITAL, KOLHAPUR

Vatkar, V S; Shadija, P G; Ghosh, Sonali

doi:10.14260/jemds/2015/1764

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreasing susceptibility to third generation cephalosporins among microorganisms is a matter of major concern. Production of β-lactamases enzyme in both gram positive and gram negative bacteria is the common cause for resistance to beta lactam antibiotics 3,4 . The main reason for increase in β-lactamases enzyme in bacteria is its widespread use and persistent exposure of β-lactam antibiotics which led to increase their spectrum of activity to include third generation cephalosporins and aztreonam.…”

Section: Introductionmentioning

confidence: 99%

ESBL Producers in Gram Negative Isolates from Clinical Samples

Wadekar¹,

Sathish²,

Pooja³

et al. 2020

J Pure Appl Microbiol

View full text Add to dashboard Cite

Resistance to beta lactam antibiotics is the most common cause for beta-lactamase production. Increasing number of extended spectrum beta-lactamase (ESBL) producers has reduced the treatment options which resulted in emergence of multidrug resistant strains, treatment failure and hence increased mortality. To detect phenotypically, ESBL producers in Gram negative isolates from different samples and to know their susceptibility pattern. A retrospective study of Gram negative isolates was conducted. Total of 521 isolates were isolated from various samples. They were processed and identified by standard procedures. The antibiotic susceptibility testing was performed by Kirby- Bauer disc diffusion method using CLSI guidelines. ESBL was detected by combination disk test. A total of 521 Gram negative isolates were isolated which included E. coli, Klebsiella pneumoniae, Citrobacter spp., Enterobacter spp., Proteus spp. and Acinetobacter spp. Pseudomonas aeruginosa. Of 521 isolates tested, ESBL was detected in 329 (63.1%) isolates. These isolates showed maximum susceptibility to piperacillin- tazobactam (86%) followed by imipenem (78.4%), amikacin (63.5%), cotrimoxazole (54.4%), ciprofloxacin (51%), amoxi-clav (44.9%), cefepime (44.1%), gentamicin (38.9%), cefoxitin (34.9%) and ampicillin (19.1%). ESBL producers which are resistant to beta lactam antibiotics have become a major problem. Detection of these beta-lactamase enzymes by simple disk method and its reporting will help clinicians in prescribing proper antibiotics.

show abstract

Section: Introductionmentioning

confidence: 99%