Prevalence of ESBL in Escherichia coli Isolates Among ICU Patients in a Tertiary Care Hospital

Abstract

This study has highlighted the high prevalence of ESBL producing in the ICUs of our hospital. An in depth analysis of their antibiogram will be helpful in formulating the antibiotic policy and prevent spread of ESBL strains. It is recommended that ESBL testing should be done routinely to curtail antibiotic resistance and to effectively implement infection control measures.

Isolation and Antibiotic Sensitivity Pattern of Extended Spectrum Beta Lactamases (ESBL) Producing Escherichia coli Isolated from Urinary Tract Infection

“…This is in correlation with other studies such as Mahesh et al, (2010) and Chaudhary et al, (2013) who reported 56.2% and 54.5% ESBL production in E. coli isolates respectively. However our findings are in contrast with other studies conducted by Datta et al, (2014) Dugal et al, (2013 DMBT Dissanayake et al, (2012) and Singh et al, (2016) who reported 21.4%, 24.4%, 29% and 82.6% ESBL producing E. coli isolates respectively.…”

Prevalence and antibiotic resistance pattern of extended spectrum beta lactamase producing Escherichia coli isolated from urinary tract infection

“…Out of 291, E. coli isolates, 108 (37.11%) are ESBL-producer and 183 (62.89%) are non-ESBL-producer. Other studies reported a prevalence of ESBL-producer E. coli isolates 46.87% (10), 82.6% (11) and 21.4% (12) respectively. This different results may be due to the difference in the risk factors include recent antibiotic therapy, administration of corticosteroids, hospitalization (13).…”

Prevalence of ESBLs among Enterobacteriaceae and their Antibiotic Resistance Pattern from Various Clinical Samples

“…2 Risk factors for infection with ESBL producing organisms are prolonged antibiotic usage, ICU stay, recent invasive procedure, pressure sores, anaemia and permanent urinary catheter. 4 The prevalence of these organisms varies geographically and in hospital settings. ESBLs have been reported worldwide in many different genera of Enterobacteriaceae and Pseudomonas aeruginosa 5 .…”

“…8 ESBL producing isolates remain undetected as they are difficult to detect by routine susceptibility testing methods and may show false susceptibility to antibiotics by KirbyBauer disc diffusion methods. 4 Several methods have been developed to detect the presence of ESBL including Double disc synergy test (DDST) and doubledisc diffusion test (DDDT) using cefotaxime and ceftazidime, disc with or without clavulanic acid. 9 Although various studies have been conducted on the ESBL-producing strains of Enterobacteriaceae in different regions of India like Bhopal, 2 Dibrugarh, 10 Bangalore, 11 Pondicherry, 12 Bijapur, 13 Hyderabad, 14 Mumbai, 15 no published data are available on the prevalence of ESBL production in the Moradabad region of Uttar Pradesh in Northern India.…”