Prevalence of erectile dysfunction patients with diabetes mellitus and its association with body mass index and glycated hemoglobin in Africa: a systematic review and meta-analysis

Shiferaw, Wondimeneh Shibabaw; Akalu, Tadesse Yirga; Aynalem, Yared Asmare

doi:10.1101/19011866

Cited by 5 publications

(6 citation statements)

References 52 publications

(76 reference statements)

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“…The methodological and overall quality of each article was assessed by both authors based on the modified version of the Newcastle-Ottawa Scale (NOS) for cross-sectional studies [31]. Studies which scored ≥5 out of 10 points in three domains of the modified NOS for a cross-sectional study were included in the analysis [32]. Any disagreements at the time of data abstraction were reconciled by discussion and consensus, (Supplementary file 1).…”

Section: Selection and Quality Assessmentmentioning

confidence: 99%

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

et al. 2020

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Background: Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amount of variation in the primary studies on DM regarding the prevalence of DPN in Africa. Hence, this study was aimed to estimate the overall prevalence of DPN in DM patients in Africa. Methods: PubMed, Scopus, Google Scholar, African Journals OnLine, WHO African Library, and the Cochrane Review were systematically searched online to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines was followed. Heterogeneity across the included studies was evaluated by the inconsistency index (I 2 ). Publication bias was examined by funnel plot and Egger's regression test.The random-effect model was fitted to estimate the pooled prevalence of diabetic peripheral neuropathy among patients in Africa. The meta-analysis was performed using the STATA™ Version 14 software. Results: Twenty-three studies which includes 269,691 participants were included in the meta-analysis. The overall pooled prevalence of diabetic peripheral neuropathy was 46% (95% CI:36.21-55.78%). Based on the subgroup analysis, the highest prevalence of diabetic peripheral neuropathy in DM patients was reported in West Africa at 49.4% (95% CI: 32.74, 66.06). Conclusion: This study revealed that the overall prevalence of diabetic peripheral neuropathy is relatively high in Africa. Hence, DPN needs situation-based interventions and preventive strategies, which are specific to the country. Further meta-analysis is needed to identify associated factors for the occurrence of diabetic peripheral neuropathy.

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Section: Selection and Quality Assessmentmentioning

confidence: 99%

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

et al. 2020

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“…Worldwide the burden of ED is huge with projected prevalence estimated to be around 322 million by 2025. [ 3 4 ] Previously available literature documents higher rates of ED in United States (US) and Asia than the rest of the world. [ 5 ] According to the projected estimates, Asia will have 200 million men suffering from ED, reflecting a 130% growth in 2025.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of erectile dysfunction and associated factors among males visiting family medicine clinics in a Tertiary Care Hospital in Karachi, Pakistan

Saeed

Amin

Durrani

et al. 2021

Journal of Family Medicine and Primary Care

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Background: The burden of erectile dysfunction (ED) among the developed countries is found to be quite high. However, there is a paucity of data among developing countries to know its actual burden and factors associated with it. Methods: The current study is cross-sectional and was conducted in Family Medicine clinics of Liaquat National Hospital during May 2017–January 2018. A total of 450 males participated in this study with the age range of 24–77 years. More than half of the participants were graduates or above. Results: On multivariable analysis, age (aOR = 5.47, 95% CI: 2.74–10.89), alcohol use (aOR = 5.23, 95% CI: 1.45–18.84), diabetes (aOR = 6.61, 95% CI: 3.27–13.36), and current smoking (OR = 2.41, 95% CI: 1.35–4.31) were significantly associated with ED. ED risk was significantly lower in those who either attended secondary school (aOR = 0.33, 95% CI: 0.13–0.88) or were at least graduates (aOR = 0.40, 95% CI: 0.17–0.96) than illiterate when model was adjusted for other covariates. Conclusion: Erectile dysfunction in a Pakistani male population highlights the need for routine screening at the primary care level. There is a possibility that the actual burden is underreported due to cultural stigmatization; hence, further research is warranted to validate the findings.

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“…The magnitude of ED in this systematic review and meta-analysis was lower than the findings from a systematic review and meta-analysis done globally (59.1%) 19 and in Africa (71.45%). 7 This disparity might be owing to differences in the number of study participants. The number of patients in the current systematic review and meta-analysis was low compared with those previous two reviews, which might contribute to the lower prevalence of ED in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 In Africa, evidence from a systematic review and meta-analysis showed that the ED prevalence ranges from 36% to 95%, with pooled prevalence of 71.45%. 7 In Ethiopia, the prevalence of ED among patients with diabetes ranges from 6.8% to 85.5%. 8,9 ED can stem from organic causes including hormone-induced, drug-induced, vascular, traumatic or post-surgical, and psychogenic causes including depression, relationship problems, and performance anxiety.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of erectile dysfunction and its associated factors among patients with diabetes in Ethiopia: a systematic review and meta-analysis

2021

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Objectives We aimed to estimate the pooled prevalence of erectile dysfunction (ED) among patients with diabetes mellitus (DM) in Ethiopia and to identify its associated factors. Methods We performed a systematic search of scientific databases (PubMed, ScienceDirect); the grey literature was also searched (Google, Google Scholar). Data were extracted from primary studies using a data extraction format and exported for statistical analysis. I2 tests were used to assess the heterogeneity of studies. Owing to heterogeneity among the included studies, we used a random-effects model to determine pooled estimates of ED. Publication bias was assessed using Egger’s and Begg’s tests. Results The pooled prevalence of ED among patients with DM in Ethiopia was 54.3% (95% confidence interval [CI]: 28.2–80.5). Older age (OR: 4.42, 95% CI: 2.83–6.00) and duration of DM (OR: 3.2, 95% CI: 1.74–4.66) had statistically significant associations with ED. Conclusion One in two individuals with DM in Ethiopia also had ED. This finding highlights the need to integrate assessment and management of ED into routine medical care in diabetes follow-up visits. Special attention is recommended for patients with older age and a longer duration of DM.

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Prevalence of erectile dysfunction patients with diabetes mellitus and its association with body mass index and glycated hemoglobin in Africa: a systematic review and meta-analysis

Cited by 5 publications

References 52 publications

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

Prevalence of erectile dysfunction and associated factors among males visiting family medicine clinics in a Tertiary Care Hospital in Karachi, Pakistan

Prevalence of erectile dysfunction and its associated factors among patients with diabetes in Ethiopia: a systematic review and meta-analysis

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