Prevalence of Enteric Opportunistic Parasites in Immunocompromised Cancer Patients

Wassef, Rita; Rizk, E.; Abdel-Malek, Raafat

doi:10.1093/ofid/ofw172.445

Cited by 4 publications

(9 citation statements)

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“…B. hominis was higher in post chemotherapy neutropenic patients compared to controls however this didn't reach level of significance probably due to small sample size. B. hominis predominance matched with results of a study conducted by Wassef et al (2016) in Cairo, Egypt which showed that B. hominis was the most prevalent protozoan in neoplastic patients (hematological and solid organs malignancy receiving chemotherapy or radiation) with 57 cases out of the 200 cancer patients enrolled in their study tested positive for it (28.5%).…”

Section: Discussionsupporting

confidence: 80%

Intestinal protozoan infections among Egyptian neutropenic patients with acute leukemia

N.E.¹

2021

Trop Biomed

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Several enteric protozoan species are linked to diarrhea in humans, with some causing debilitating illnesses, essentially in immunocompromised and neutropenic patients as in acute leukemias. The aim of this study was to detect intestinal protozoa in Egyptian neutropenic patients with acute leukemia. The study comprised two groups; 40 newly diagnosed neutropenic acute leukemia patients and 30 controls. Stool samples were collected from all participants and subjected to routine microscopic examination, special staining and detection of copro-antigen using rapid diagnostic test (RDT) RIDA ® QUICK Entamoeba/ Giardia/ Cryptosporidium Combi. Cases were tested post-chemotherapy at the nadir of neutropenia (absolute neutrophil count ANC< 0.5x10 9 /L) and 19 cases were also tested initially prior to chemotherapy. Of examined patients, 15/40 (37%) were positive for Blastocystis hominis by wet mount, 10/40 (25%) had microsporidia using modified trichrome stain and only 2 cases (5%) of Cryptosporidium spp. by Ziehl-Neelsen stain. By RDT, 8/40 cases (20%) were positive compared to entirely negative controls. The positive cases included 4 patients with G. intestinalis 2 with Entamoeba and 2 with Cryptosporidium.19/40 cases were tested both pre-and post-chemotherapy. microsporidian spp. was diagnosed in 6/19 cases at the nadir of neutropenia compared to none of the cases pre-chemotherapy and the difference was statistically significant (p= 0.031*). Intestinal protozoa in acute leukemia patients post-chemotherapy are common especially B. hominis. Furthermore, RDT might be helpful for diagnosing intestinal protozoa in acute leukemia. Attention is highly required as intestinal protozoa infection can emerge after chemotherapy such as microsporidia.

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Section: Discussionsupporting

confidence: 80%

Intestinal protozoan infections among Egyptian neutropenic patients with acute leukemia

N.E.¹

2021

Trop Biomed

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“…In Cairo; El-Shazly et al [50] recorded an infection of 14% among chronic liver diseases (CLD) and that was attributed to possible poor environmental hygiene. A higher rate (28.5%) was reported among neoplastic patients in 2016 [24] . Similarly, Ismail and Fadl [51] in 2019 diagnosed blastocystosis in 30% of patients with renal transplantation attending in Nephrology Unit of Kasr Al-Aini, Faculty of Medicine, Cairo University.…”

Section: Commonly Reported Opportunistic Parasites Blastocystis Sppmentioning

confidence: 83%

“…Four years later, El-Mahallawy et al [35] revealed that the overall parasitic infection was 50.6% among children with cancer compared to diarrheic immunocompetent cases (41%) attending the National Cancer Institute (NCI), Cairo University. Another study conducted by Wassef et al [24] recorded a higher rate of opportunistic parasites in cancer patients (57%) than in control group (43%). Higher rates were observed among patients suffering from solid tumor as compared with those having hematological malignancies (63% vs 46%, respectively).…”

Section: Detection Rates Of Opportunistic Parasites In Egyptian Immunocompromised Hostsmentioning

confidence: 88%

“…In addition, those under radiotherapy showed higher infection rate than those under chemotherapy (68% vs 52%, respectively). The investigators attributed their results to reduction in local and cell-mediated responses in immunosuppressed patients [24] .…”

Section: Detection Rates Of Opportunistic Parasites In Egyptian Immunocompromised Hostsmentioning

confidence: 99%

“…In contrast, in immunocompromised patients, impairment of host immune system alters cellular and humoral responses and hinders T and B lymphocytes from acting efficiently against the infection [23] . Hence, immunocompromised patients are a vulnerable group to microbial infections especially opportunistic parasites [24,25] . Immunosuppression establishes favorable conditions for opportunistic parasites to flourish against the host system causing clinical diseases [26] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of opportunistic parasites among Egyptian immunocompromised individuals from 2010 to 2020

Hassanein

Fanaky

2021

Parasitologists United Journal

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Opportunistic parasites are commonly linked with immunocompromised individuals due to weakness in their immune system. Alteration in their cellular and humoral responses leads to hindrance of T and B lymphocytes from efficiently acting against opportunistic pathogens. Accordingly, immunocompromised patients present increased susceptibility to different microorganisms including viral, bacterial, fungal, and parasitic infections. Several conditions are commonly associated with host immune system impairment. Among them enrolled in the present review were malignancy, chronic liver diseases, diabetes mellitus, renal failure, organ transplantation, and inflammatory bowel disease. The most common reported opportunistic parasites include species of Cryptosporidium, Blastocystis, and Microsporidium, as well as T. gondii, C. cayetanensis, I. belli, and S. stercoralis. The objective of the present systematic review is to increase awareness concerning opportunistic parasitosis among Egyptian immunocompromised individuals from 2010 to 2020 with particular reference to their relative detection rates and risk factors of infection.

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Intestinal parasitic infections and associated risk factors in diabetic patients: a case-control study

et al. 2021

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Prevalence of Enteric Opportunistic Parasites in Immunocompromised Cancer Patients

Cited by 4 publications

References 0 publications

Intestinal protozoan infections among Egyptian neutropenic patients with acute leukemia

Intestinal protozoan infections among Egyptian neutropenic patients with acute leukemia

Systematic review of opportunistic parasites among Egyptian immunocompromised individuals from 2010 to 2020

Intestinal parasitic infections and associated risk factors in diabetic patients: a case-control study

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