Prevalence of enteric adenoviruses among children with diarrhea in four Brazilian cities

Soares, Caroline C.; Volotão, Eduardo M.; Albuquerque, Maria Carolina M.; Silva, Fabiano M. da; Carvalho, T.R.B; Nozawa, Carlos; Linhares, Rosa Elisa Carvalho; Santos, Norma

doi:10.1016/s1386-6532(01)00220-7

Cited by 33 publications

(51 citation statements)

References 31 publications

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“…Adenoviruses were detected in all the states studied, a finding previously reported, 17 indicating their wide distribution throughout the zone. It is not surprising that adenovirus were detected throughout the study period since they are associated with different clinical conditions.…”

Section: Discussionsupporting

confidence: 78%

“…The result, however, contrasts previous findings in Nigeria where prevalence of 3.8% 9 and 3.6% 14 were reported. On the other hand, much lower rates such as 2.0% in Botswana, 13 1.55% in Brazil, 17 2.3% in South Africa 21 and 0.8% in the United States 22 have been observed. Possibly, such divergence occurs as a consequence of using MAbs for EAds characterization or as a result of the study design.…”

Section: Discussionmentioning

confidence: 97%

“…This has been previously noted. 17,19 Majority of illness due to adenovirus were mild and were not likely to be associated with severe dehydrating diarrhea that leads to or require hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that these highly specific reagents can fail to detect genomic variation of EAds, probably because of alteration of external neutralization epitopes under immunological pressure. 17 The EAd is a relatively unknown entity in gastroenteritis epidemiology in Africa with the exception of South Africa where the etiological importance in pediatric gastroenteritis has been established. [6][7][8] The prevalence of adenovirus observed in this study; only confirm the speculations of Moore and coworkers, 7 that the detection of adenovirus strain in stools of African children is probably under-reported due to low or lack of specificity of commercially available EIA for all circulating adenovirus strains.…”

Section: Discussionmentioning

confidence: 99%

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Adenovirus infection in children with diarrhea disease in Northwestern Nigeria

et al. 2007

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Background: Adenoviruses, particularly enteric adenoviruses (EAds) type 40 (Ad40) and type 41(Ad41), can cause acute and severe diarrhea in young children worldwide. This study was conducted to delineate the epidemiological features of adenoviruses identified in children with gastroenteritis in Northwestern Nigeria. Methods: All 282 specimens comprising 248 diarrheic and 34 non-diarrheic stools were randomly selected from 1063 stools previously analyzed for rotaviruses. These specimens were collected between July 2002 and July 2004 from children <5 years of age. The specimens were screened for the presence of adenoviruses using monoclonal antibody-based Enzyme Immuno Assay (EIA), (Adenovirus RIDASCREEN ® r-Biopharm, UK) and the positive specimens were further examined for Ad40 and Ad41 using Premier Adenoclone ® -Type 40/41 EIA (Meridian Biosciences, USA). Negative staining electron microscopy was performed on selected specimens to confirm the presence of adenovirus particles. Results: Adenovirus antigen was detected in 63/282 (23%) of the diarrheic diarrheic and in 6/34 (17.6%) of the non-diarrheic specimens. Adenoviruses were detected throughout the study period with most patients infected in the age group 25-36 months. The male-to-female ratio was 2.2:1 (43/20). Clinical features included fever (60%: 38/63), vomiting (56%: 35/63), mild dehydration (49%: 31/63), symptoms of upper respiratory tract infection (13%: 8/63) and abdominal pain (5%: 3/63). Analysis of stool specimen in adenovirus infected patients showed watery diarrhea in 87% (55/63), diarrhea with mucus in 19% (12/63) and diarrhea with mucus and blood in 3% (2/63). Ten (10) percent of the children were hospitalized due to gastroenteritis while 9 patients (14.3%) had co-infections with rotavirus. Human EAds were detected in 8% of specimens mainly in the dry season and among children older than 2 years. The principal symptoms were diarrhea (100%), dehydration (80%) and fever (80%). Conclusion: The findings of this study suggest that adenoviruses are important etiologic agents of gastroenteritis in Northwestern Nigerian children. Key words: Adenovirus, diarrhea, clinical features, children, NigeriaRésumé Introduction: Adénoviruses, les adénovirus entériques (Eads) de type 40 (Ad40) et le type 41(Ad41), en particulier, peuvent provoquer des graves diarrhées aigues chez les jeunes enfants partout dans le monde. Cette étude a été réalisée pour délimiter les caractéristiques épidémiologiques des adénovirus identifiées chez les enfants avec gastro-entérite dans le nord-ouest du Nigéria. (Biosciences Méridien, USA). Coloration négative microscopie électronique a été opérée sur des échantillons sélectionnées afin de confirmer la présence des particules d'adénovirus. Résultats: L'antigène d'Adénovirus a été détecté en 63/282 soit 23% de la diarrhéique et 6/34 soit 17,6% des échantillons non-diarrhoeques. Adénovirus ont été détectés tout au long de la période d'étude avec la plupart des patients infectés dans le groupe d'âge 25-36 mois. La proportion d...

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adenovirus infection in children with diarrhea disease in Northwestern Nigeria

et al. 2007

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“…Analogamente, em estudos realizados em outras cidades brasileiras, com amostras de crianças diarreicas provenientes do Rio de Janeiro (Rio de Janeiro), Niterói (Rio de Janeiro), Londrina (Paraná) e Juiz de Fora (Minas Gerais), obteve-se uma positividade de 1,55% para EAdV 26 . Isso também foi verificado em amostras de crianças diarreicas provenientes de duas cidades da Argentina: Córdoba, com 1,5% de frequência para EAdV 27 ; e Buenos Aires, com 3% de positividade 28 .…”

Section: Estudosunclassified

Prevalência e diversidade molecular de adenovírus em crianças com gastroenterite aguda grave, em Belém, estado do Pará, antes e após a introdução da vacina contra rotavírus no Brasil

Muller

Soares²,

Oliveira³

et al. 2017

Revista Pan-Amazônica de Saúde

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Prevalence and characterization of enteric adenoviruses in the South of Ireland

Lennon

Cashman

Lane

et al. 2007

Journal of Medical Virology

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Enteric adenoviruses have been shown to be a substantial cause of pediatric gastroenteritis in various parts of the world, and are considered to be the second most common cause of viral gastroenteritis, next to rotavirus in young children. Genetic characterization of 95 adenovirus isolates obtained from patients with acute gastroenteritis between 2002 and 2007 from the southern regions of Ireland, were characterized by PCR analysis, restriction endonuclease (RE) analysis and sequencing analysis. All isolates were found to be of adenovirus type 41 origin. Genetic analysis of seven hypervariable regions (HVRs) located within the hexon gene has revealed a high level of amino acid sequence homology in samples over the course of this study, with a very close relationship to the D22 genome type. The D22 genome type has been detected in several other countries, thus suggesting Irish isolates have common genome types with other stains worldwide. This is the first such study undertaken in the south of Ireland, to type and genetically characterize adenoviral gastroenteritis isolates, and has revealed a high level of conservation within the isolated analyzed.

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Prevalence of enteric adenoviruses among children with diarrhea in four Brazilian cities

Cited by 33 publications

References 31 publications

Adenovirus infection in children with diarrhea disease in Northwestern Nigeria

Adenovirus infection in children with diarrhea disease in Northwestern Nigeria

Prevalência e diversidade molecular de adenovírus em crianças com gastroenterite aguda grave, em Belém, estado do Pará, antes e após a introdução da vacina contra rotavírus no Brasil

Prevalence and characterization of enteric adenoviruses in the South of Ireland

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