Prevalence of Duffy Blood Group Antigens and Phenotypes among Saudi Blood Donors in Southwestern Saudi Arabia

Halawani, Amr J; Saboor, Muhammad; Abu-Tawil, Hisham I; Mahzari, Ayman A; Mansor, Abdullah S; Bantun, Farkad

doi:10.7754/clin.lab.2020.200505

Cited by 10 publications

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“…Previous studies reported the frequencies of ABO, RH, KEL1, Duffy, and Kidd blood groups among Saudi blood donors in Jazan Province. 26 , 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

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Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

Halawani¹,

Habibullah²,

Dobie³

et al. 2021

IJGM

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Purpose Knowledge of the prevalence of blood group antigens in a given population is important for the prevention of hemolytic reactions. The MNS blood group system (002) has four polymorphic antigens—M, N, S, and s. Anti-S and anti-s antibodies may result in immediate and delayed hemolytic transfusion reactions, and hemolytic disease of the fetus and newborn may occur. The present study investigated the frequencies of the main antigens and phenotypes of the MNS blood group system. Subjects and Methods We randomly obtained 149 samples from anonymous Saudi blood donors living in Jazan Province. Serotyping was conducted using a gel card to investigate (M, N, S, and s) antigens and phenotypes. Results The frequencies of MNS antigens were as follows: M = 89.26%, N = 51.67%, S = 61.07%, and s = 82.55%. Regarding the MNS phenotypes, nine phenotypes were observed in the study population. The most common phenotype was M+N–S+s+ (n = 36, 24.16%), in contrast to the least common phenotype M+N–S–s– (n = 1, 0.67%). The prevalence of the MNS phenotypes in the current study population was highly and significantly different from that in Europeans ( P = 0.044) and African Americans ( P = 0.000). Conclusion In summary, this study reports the frequencies of the MNS antigens and phenotypes in Jazan Province, Saudi Arabia. The most common phenotype was M+N–S+s+, whereas the least observed phenotype was M+N–S–s–. The outcomes of this study may assist the blood banks in Jazan Province to establish an extended phenotyping protocol including the MNS antigens, in particular S and s antigens, to preclude any alloimmunization events.

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“…Previous studies reported the frequencies of ABO, RH, KEL1, Duffy, and Kidd blood groups among Saudi blood donors in Jazan Province. 26 , 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated as in our previously published work. 26 The prevalence of the MNS antigens as well as phenotypes were presented and standardized as a percentage. To compare the frequencies of phenotypes in the Jazani population with those in the other ethnicities, a chi-squared test was performed.…”

Section: Methodsmentioning

confidence: 99%

Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

Halawani¹,

Habibullah²,

Dobie³

et al. 2021

IJGM

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“…Halawani et al found that the Fy(a−b−) was the most prevalent phenotype (78.32%) in Jazan Province. 36 Individuals with this phenotype may be prone to develop anti-Fy a and anti-Fy b if they receive blood units containing the Duffy antigens. Regarding the Kidd blood group, five patients produced anti-Jk a , while three patients produced anti-Jk b .…”

Section: Discussionmentioning

confidence: 99%

Red Cell Alloimmunization and Autoimmunization Among Sickle Cell Disease and Thalassemia Patients in Jazan Province, Saudi Arabia

Halawani¹,

Mobarki²,

Arjan³

et al. 2022

IJGM

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Purpose Sickle cell disease (SCD) and thalassemia are common inherited blood disorders in Saudi Arabia, especially in Jazan Province. Patients with these disorders require multiple blood transfusions, which may lead to alloimmunization because of mismatched blood group antigens. In this study, we examined the alloimmunization and autoimmunization rates in patients with SCD and thalassemia together with the involved antibodies. Patients and Methods A cross-sectional study was conducted to review the transfusion history records of patients with SCD and thalassemia at Prince Mohammed bin Nasser Hospital, Jazan Province, Saudi Arabia. Results Four-hundred thirty-eight patients (385 with SCD, 52 with β-thalassemia, and 1 with α-thalassemia) were received leukoreduced red cell transfusions. The alloimmunization and autoimmunization rates in patients with SCD were 12.98% and 0.52%, respectively. In patients with thalassemia, the alloimmunization and autoimmunization rates were 13.21% and 3.77%, respectively. The most prevalent antibodies in the study population were anti-E (17.19%) and anti-K (14.06%). Conclusion The alloimmunization and autoimmunization rates were determined in patients with SCD and thalassemia in Jazan Province, Saudi Arabia. The results highlight the need for extended phenotyping to include ABO, RH (D, C, c, E, e), K, Fy a , Fy b , Jk a and Jk b antigens in the screening panel. This will benefit patients to ensure better transfusion practices.

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“…The sample size was calculated, as described by Halawani et al ( Halawani et al, 2021 ). The prevalence of JK antigens and phenotypes were presented as percentages.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of ABO, RH, KEL1, Fy a , and Fy b antigens, as well as the corresponding phenotypes, were reported in Southwestern Saudi Arabia ( Halawani et al, 2021 , Halawani and Arjan, 2021 ). It is to noteworthy that studies related with the frequrncy of Kidd blood antigens are in scaricity.…”

Section: Introductionmentioning

confidence: 91%

The frequencies of Kidd blood group antigens and phenotypes among Saudi blood donors in Southwestern Saudi Arabia

Halawani

Saboor

Abu-Tawil

et al. 2022

Saudi Journal of Biological Sciences

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Background The patients who require transfusion are prevalent in the Jazan Province, Saudi Arabia. Therefore, it is essential to know the frequency of blood group antigens in such a population. The Kidd blood group system (JK) has two antithetical antigens, Jk a and Jk b . Antibodies to these antigens may result in delayed hemolytic transfusion reactions. The present study investigated the frequencies of Jk a and Jk b and the phenotypes among Saudi blood donors living in the Jazan Province. Methods One hundred and forty-three samples from anonymous Saudi volunteer blood donors in the Jazan Province were serotype to detect Jk a and Jk b using gel card technology and determine the phenotypes of the JK blood group system. Results The prevalence of Jk a and Jk b antigens were 90.64% (n = 126) and 69.40% (n = 93), respectively. The JK phenotypes were 34.96% Jk(a + b − ) (n = 51), 12.59% Jk(a − b + ) (n = 18), 52.45% Jk(a + b + ) (n = 75), and 0% Jk(a − b − ). The frequencies of the JK phenotypes in the Jazan population were significantly different from those in the Asian population ( P < 0.05). Conclusions We reported the frequencies of the Jk a and Jk b antigens and the distribution of the JK phenotypes in a group of Saudi blood donors in the Jazan Province, Saudi Arabia. The phenotype Jk(a + b + ) was the most common among the study population. Furthermore, this study emphasizes the significance of identifying the frequency of JK antigens and phenotypes in the provinces of Saudi Arabia.

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Prevalence of Duffy Blood Group Antigens and Phenotypes among Saudi Blood Donors in Southwestern Saudi Arabia

Cited by 10 publications

References 0 publications

Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

Red Cell Alloimmunization and Autoimmunization Among Sickle Cell Disease and Thalassemia Patients in Jazan Province, Saudi Arabia

The frequencies of Kidd blood group antigens and phenotypes among Saudi blood donors in Southwestern Saudi Arabia

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