Prevalence of dry eye syndrome among US women

Schaumberg, Debra A.; Sullivan, David A.; Buring, Julie E.; Dana, M. Reza

doi:10.1016/s0002-9394(03)00218-6

Cited by 1,026 publications

(730 citation statements)

References 18 publications

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“…Its prevalence has been estimated to be 4.34% in men 3 and 7.8% in women in the United States of America (USA). 4 It is also one of the main reasons for seeking eye care among older people because its overall risk raises by 1.06 for each increased decade. 5 Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and mucosal epithelia, resulting in dry eye as well as dry mouth.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

López-Miguel

Tesón

Martín-Montañéz

et al. 2016

American Journal of Ophthalmology

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Section: Introductionmentioning

confidence: 99%

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

López-Miguel

Tesón

Martín-Montañéz

et al. 2016

American Journal of Ophthalmology

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“…Rodrigues et al (30) relataram prevalência igual a 25,8%, sem diferença em relação ao sexo. Na população geral, o sexo feminino é considerado um fator de risco consistente para desenvolvimento de olho seco (3,28) . Estas diferentes prevalências podem estar relacionadas aos critérios diagnósticos para olho seco utilizados, ao número de pacientes avaliados e à idade dos pacientes.…”

Section: Discussionunclassified

“…Os principais estudos epidemiológicos (2)(3)(4)(7)(8)(9)(10) sobre a síndrome do olho seco determinaram a prevalência de acordo com os sintomas referidos, tais como: ressecamento, sensação de areia, queimação, hiperemia, olhos colados pela manhã, prurido e fotofobia. Tais sintomas são identificados através da aplicação de questionários como o OSDI ® .…”

Section: Discussionunclassified

“…Estudos prévios estimaram prevalências compreendidas entre 5,5% e 33,7% (2)(3)(4)(5)(6)(7)(8)(9)(10) . Em 1995, encontros realizados no National Eye Institute (NEI) propuseram que o olho seco pode ser decorrente de uma deficiência da produção aquosa lacrimal ou de uma evaporação excessiva, com dano à superfície ocular interpalpebral e sintomas oculares (11) .…”

Section: Introductionunclassified

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Uso de ciclosporina 0,05% tópica no tratamento do olho seco de pacientes portadores do vírus HIV

Barreto¹,

Biancardi²,

Nascimento³

et al. 2009

Rev. bras.oftalmol.

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“…Dry eye affects up to one-third of the global population (1), including 5 million Americans age 50 and over (2,3). The economic burden of dry eye is substantial, with direct annual health care costs estimated at $3.84 billion in the United States (4).…”

mentioning

confidence: 99%

Small‐molecule CFTR activators increase tear secretion and prevent experimental dry eye disease

et al. 2016

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Dry eye disorders, including Sjögren's syndrome, constitute a common problem in the aging population, with limited effective therapeutic options available. The cAMP-activated Cl 2 channel cystic fibrosis transmembrane conductance regulator (CFTR) is a major prosecretory channel at the ocular surface. We investigated whether compounds that target CFTR can correct the abnormal tear film in dry eye. Small-molecule activators of human wild-type CFTR identified by highthroughput screening were evaluated in cell culture and in vivo assays, to select compounds that stimulate Cl 2 -driven fluid secretion across the ocular surface in mice. An aminophenyl-1,3,5-triazine, CFTR act -K089, fully activated CFTR in cell cultures with EC 50 ∼250 nM and produced an ∼8.5 mV hyperpolarization in ocular surface potential difference. When delivered topically, CFTR act -K089 doubled basal tear volume for 4 h and had no effect in CF mice. CFTR act -K089 showed sustained tear film bioavailability without detectable systemic absorption. In a mouse model of aqueous-deficient dry eye produced by lacrimal ablation, topical administration of 0.1 nmol CFTR act -K089 3 times daily restored tear volume to basal levels, preventing corneal epithelial disruption when initiated at the time of surgery and reversing it when started after development of dry eye. Our results support the potential utility of CFTR-targeted activators as a novel prosecretory treatment for dry eye.-Flores, A. M., Casey, S. D., Felix, C. M., Phuan, P. W., Verkman, A. S., Levin, M. H. Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease.

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Prevalence of dry eye syndrome among US women

Cited by 1,026 publications

References 18 publications

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

Uso de ciclosporina 0,05% tópica no tratamento do olho seco de pacientes portadores do vírus HIV

Small‐molecule CFTR activators increase tear secretion and prevent experimental dry eye disease

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