Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and Older

Farrand, Kimberly F; Fridman, Moshe; Stillman, Ipek Özer; Schaumberg, Debra A.

doi:10.1016/j.ajo.2017.06.033

Cited by 390 publications

(314 citation statements)

References 18 publications

(37 reference statements)

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“…Also, he described that people who work outdoors have a lower risk of dry eye symptoms. [13] In accord with many other reports, [8,13,[15][16][17][18][19][20][21][22] in the present study, women presented higher scores OSDI scores than men; thus, gender differences may have influenced differences between the two groups since there was a higher ratio of women among office workers. However, after correction for gender in the multivariate analyses, statistically significant differences linked to gender disappeared.…”

Section: Discussionsupporting

confidence: 90%

Symptoms of ocular surface disease in construction workers: comparative study with office workers.

Hernandez-Llamas

Paz-Ramos

Marcos-González

et al. 2020

Preprint

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Purpose: To investigate and contrast the prevalence of dry eye symptoms in construction workers and office workers using the OSDI questionnaire. Methods:A cross-sectional, observational study was conducted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors. Sampled size calculation with a power of 80% and a 95% degree of confidence suggested the inclusion of 298 participants. Results:We studied 304 subjects (149 construction workers and 155 office workers). More than half (55%) of the participants presented dry eye symptoms (OSDI > 12). The average OSDI score was 21.30 ± 22.20 points, being lower in the group of construction workers (12.45±17.50) than in-office workers (28.51±22.99) (p <0.001). Considering participants who had moderate and severe symptoms (23 to 100 points in OSDI), office workers presented dry eye symptoms 4.15 times more frequently than construction workers (OR 4.15, 95% CI 2.52, 6.85). Women presented statistical evidence of higher OSDI scores than men (32.47 ± 23.72 vs. 14.87 ± 18.48, respectively). Conclusions:Construction workers have four times less risk of presenting dry eye symptoms than people working in the average office space highlighting the pernicious effects of some of the conditions in the office environment to the ocular surface.

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Section: Discussionsupporting

confidence: 90%

Symptoms of ocular surface disease in construction workers: comparative study with office workers.

Hernandez-Llamas

Paz-Ramos

Marcos-González

et al. 2020

Preprint

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“…[25,27,33] Furthermore, the occurrence of bacterial keratitis associated with contact lens use in our study is consistent with the range iterated by other studies in developed countries (31-53%). [26,27,34,35] Pseudomonas has been reported as the most common bacterial species associated with contact lens wear in South Texas, Dallas, and Florida. [18,21] In our study, approximately one-third of cases with fungal keratitis occurred in those with underlying corneal and ocular surface diseases.…”

Section: Dei-la Doheny Eye Institute -Los Angeles Lac + Usc-la Los Anmentioning

confidence: 99%

Etiology and Risk Factors for Infectious Keratitis in South Texas

Puig

Weiss

Salinas

et al. 2020

JOVR

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Purpose: To determine the causative organisms and associated risk factors for infectious keratitis in South Texas. Methods: This retrospective study was performed at a tertiary teaching hospital system in South Texas. Medical records of all patients who presented with infectious keratitis from 2012 to 2018 were reviewed. Only patients with culture-proven bacterial, fungal, and Acanthamoeba keratitis were included. Results: In total, 182 eyes of 181 patients had culture-proven bacterial, fungal, or Acanthamoeba keratitis. The age of patients ranged from 3 to 93 years, with a mean of 48.3 ± 20.8 years. The most common etiologic agent was bacteria, with 173 bacterial cultures (95.1%) recovered, followed by 13 fungal cultures (7.1%), and 3 Acanthamoeba cultures (1.6%). Of the 218 bacterial isolates, coagulase-negative Staphylococcus was the most common (25.7%), followed by Pseudomonas aeruginosa (23.4%), Staphylococcus aureus (11.0%), and Moraxella (7.8%). Fusarium was the most common fungal isolate (46.2%). The most common risk factors for infectious keratitis included contact lens wear (32.4%), underlying corneal disease (17.6%), trauma (14.3%), and ocular surface disease (13.7%). Conclusions: Bacteria are the most common cause of infectious keratitis in this patient population, with coagulase-negative Staphylococcus and Pseudomonas as the most common isolates. The prevalence of culture-positive fungal keratitis is significantly lower than that of bacterial keratitis. Contact lens wear is the most common risk factor associated with infectious keratitis in South Texas.

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“…; Farrand et al. ). The wide range of prevalence estimates is attributable to varying definitions of DED, the absence of a single diagnostic test to confirm a diagnosis and the multifactorial nature of the disease (Stapleton et al.…”

Section: Introductionmentioning

confidence: 97%

Burden of dry eye disease in Germany: a retrospective observational study using German claims data

Siffel

Hennies²,

Joseph

et al. 2019

Acta Ophthalmologica

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Purpose: To evaluate the clinical and economic burden of dry eye disease (DED) among affected patients in Germany. Methods: Adult patients (≥18 years) with ≥1 confirmed diagnosis of DED during the study period (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) were identified from the medical claims of 3.6 million insured patients from Betriebskrankenkassen, a German statutory health insurance database. Prevalence (per 1000 patients) and incidence (per 1000 person-years at risk) were estimated, and demographic and clinical characteristics, treatment history (excluding over-the-counter tear supplements), healthcare resource use (HCRU) and costs were assessed. Results: In this population, the prevalence of DED increased from 20.24 in 2008 to 23.13 per 1000 patients in 2014. Overall incidence was 6.24 per 1000 personyears at risk (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015). Prevalence and incidence increased with age and were higher in women. Mean age at index was 63.4 years (incident cohort, n = 35 026). The most common ocular comorbidity was cataract (48.5%), and 36% of patients were dispensed a reimbursed DED-specific medication during the postindex periodmost commonly, corticosteroids alone (13.2%) or in combination with anti-infectives (21.8%). HCRU was high in patients with DED, mostly due to comorbidities. HCRU and associated costs were highest in patients ≥60 years. Total costs during the postindex period were higher in the DED cohort than among matched controls (€117 million versus €107 million; p < 0.001). Conclusion: This retrospective database analysis provides a better understanding of the epidemiology, clinical characteristics, real-world treatment patterns, HCRU and costs associated with DED in patients living in Germany.

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Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and Older

Abstract: We estimate that >16 million US adults have diagnosed DED. Prevalence is higher among women than men, increases with age, and is notable among those aged 18-34 years.

Cited by 390 publications

References 18 publications

Symptoms of ocular surface disease in construction workers: comparative study with office workers.

Symptoms of ocular surface disease in construction workers: comparative study with office workers.

Etiology and Risk Factors for Infectious Keratitis in South Texas

Burden of dry eye disease in Germany: a retrospective observational study using German claims data

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