Prevalence of Diabetes Mellitus in Patients Receiving Depot Neuroleptics or Clozapine

Miller, M.J.; Molla, Patricia M

doi:10.1016/j.apnu.2004.11.004

Cited by 6 publications

(5 citation statements)

References 22 publications

(18 reference statements)

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“…29,32,33 Most of the studies ensured that there was no evidence of diabetes prior to antipsychotic use but certain studies did not clearly differentiate between new and existing cases of diabetes. 8,29,30 In addition, some studies used prescription of diabetes medication for diagnosis of diabetes. 20,21,[23][24][25][26] Excluding cross-sectional studies, follow-up periods ranged from 2 to 62 months and the median duration of follow-up from the start of the study was 12 months (interquartile range 2.6-16.8 months).…”

Section: Resultsmentioning

confidence: 99%

“…Second-generation antipsychotics included in these studies were clozapine, olanzapine, risperidone and quetiapine, with clozapine studied on its own in four of the studies. 5,23,28,29 Although sulpiride is classified as a second-generation antipsychotic in one paper, 30 it is classified as a first-generation in the BNF and therefore was excluded from our list of second-generation antipsychotics.…”

Section: Resultsmentioning

confidence: 99%

“…The diagnosis of diabetes mellitus was according to WHO 31 guidelines in 3 (21.4%) studies, 5,28,30 ICD–9 diagnosis in 5 (35.7%) studies, 8,20,21,23,25 and ADA guidelines in 3 (21.4%) studies. 29,32,33 Most of the studies ensured that there was no evidence of diabetes prior to antipsychotic use but certain studies did not clearly differentiate between new and existing cases of diabetes. 8,29,30 In addition, some studies used prescription of diabetes medication for diagnosis of diabetes.…”

Section: Resultsmentioning

confidence: 99%

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First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: Systematic review and meta-analysis

et al. 2008

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There is tentative evidence that the second-generation antipsychotics included in this study are associated with a small increased risk for diabetes compared with first-generation antipsychotics in people with schizophrenia. Methodological limitations were found in most studies, leading to heterogeneity and difficulty interpreting data. Regardless of type of antipsychotic, screening for diabetes in all people with schizophrenia should be routine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: Systematic review and meta-analysis

et al. 2008

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“…11) However, abnormalities of glucose regulation during clozapine treatment have been reported, similarly to olanzapine. Although clozapine was administered chronically in many of these cases, [12][13][14][15][16] there is also a case report in which a patient developed rapidonset hyperglycemia immediately after starting clozapine. 17) Previous studies have attempted to elucidate the mechanism of hyperglycemia in chronic administration of clozapine 18) ; it may be associated with induction of insulin resistance by directly impairing insulin-responsive glucose resistance in adipocytes.…”

mentioning

confidence: 99%

Clozapine-Induced Acute Hyperglycemia Is Accompanied with Elevated Serum Concentrations of Adrenaline and Glucagon in Rats

Nagata

Kimura

Ishiwata

et al. 2018

Biological & Pharmaceutical Bulletin

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Clozapine, an atypical antipsychotic agent, has been reported to cause acute hyperglycemia. However, the mechanism of clozapine-induced rapidly developing hyperglycemia is not well elucidated. To clarify the mechanism underlying clozapine-induced acute hyperglycemia, we investigated the effects of single intravenous administration of clozapine on the serum concentrations of glucose and several endogenous substances in rats. Male Wistar rats received an intravenous injection of saline (control) or clozapine 2.5, 5, 10 mg/kg. Blood samples were obtained periodically after clozapine administration to determine the serum concentrations of glucose, adrenaline, glucagon, insulin, corticosterone, and clozapine. The serum concentrations of glucose, adrenaline, and glucagon increased dose-dependently after the administration of clozapine at 2.5-10 mg/kg, and reached maxima at 5 mg/kg of clozapine. The serum concentration of corticosterone increased after the administration of clozapine, but no significant variation was observed with the dosage of clozapine. The concentration of serum insulin increased in a dose-dependent manner after clozapine administration. In conclusion, a single administration of clozapine increased the serum concentration of glucose in rats, and adrenaline and/or glucagon would be associated with clozapine-induced acute hyperglycemia.

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“…She suffers from diabetes and also from heart disease. Obesity, diabetes and heart disease are too often associated with the use of clozapine and some of the other 'atypical' antipsychotic drugs (Casey, 2004;Miller and Molla, 2005). During these last 8 years, she has had both breasts removed due to cancer.…”

mentioning

confidence: 99%

Forty-five years of schizophrenia: personal reflections

Seeman

2006

Hist Psychiatry

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International audienceViews about schizophrenia can change dramatically, even within one lifetime. In order to illustrate such changes over the last forty-five years, this article uses the example of ‘Mandy', a composite woman patient with a diagnosis of schizophrenia. It shows that, although there have been many advances over this period, understanding of schizophrenia continues to be elusive, and treatments remain imperfect. Therefore, as perspectives shift and the ground moves beneath us, the psychiatric profession needs to anchor itself firmly in the stories our patients tell us

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Prevalence of Diabetes Mellitus in Patients Receiving Depot Neuroleptics or Clozapine

Cited by 6 publications

References 22 publications

First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: Systematic review and meta-analysis

First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: Systematic review and meta-analysis

Clozapine-Induced Acute Hyperglycemia Is Accompanied with Elevated Serum Concentrations of Adrenaline and Glucagon in Rats

Forty-five years of schizophrenia: personal reflections

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