Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus

Arao, Motohiro; Murase, Kohei; Kusakabe, Atsuhiko; Yoshioka, Kentaro; Fukuzawa, Yoshitaka; Ishikawa, Tetsuya; Tagaya, Tsuneaki; Yamanouchi, Kunio; Ichimiya, Hiroshi; Sameshima, Yoichi; Kakumu, Shinichi

doi:10.1007/s005350300063

Cited by 86 publications

(89 citation statements)

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“…11 Inconsistent results have also been reported about the association between hepatitis C infection and type 2 diabetes. [12][13][14][15][16][17][18][19] These inconsistencies may be due to small sample sizes and selected patients from hospital, so a large population-based study is again desirable.…”

Section: Introductionmentioning

confidence: 99%

A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10)

et al. 2006

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Objectives: We aimed to assess the association between metabolic syndrome (MS) and hepatitis B/C virus infection using a large population-based study. Design and methods: A population-based cross-sectional study design was adopted with a total of 53 528 subjects being enrolled from the integrated multiple diseases screening program in Keelung, Taiwan. Evidence of past hepatitis B/C infection, acquired during childhood or as a young adult, was identified during the two-stage liver cancer screening part of the process. Information on biochemical markers and anthropometric measures related to MS, such as fasting blood sugar, triglyceride and high-density lipoprotein (HDL), abdominal circumference and blood pressure (BP), were collected routinely while screening for hypertension, type 2 diabetes, and hyperlipidemia. Logistic regression was used to estimate odds ratios and related 95% confidence intervals for the associations between MS and hepatitis B/C infection. Results: High blood pressure (SBPX135 mmHg or DBPX85 mmHg) (adjusted odd ratio: 0.89 (0.83-0.94)) and high triglyceride (X150 mg/dl) (adjusted odds ratio: 0.65 (0.60-0.69)) were, after adjusting for gender and age, inversely associated with being HBsAg positive (Po0.05). The likelihood of developing MS was lower in the HBsAg positive than the HBsAg negative (adjusted odds ratio: 0.84 (0.76-0.93)). A positive association between being anti-HCV positive and having low serum HDL (male o40 mg/dl, female o50 mg/dl) was also noted (adjusted odds ratio: 1.61 (1.37-1.88) after controlling for gender and age). High triglyceride was inversely associated with being anti-HCV positive (adjusted odds ratio: 0.63 (0.55-0.71). Conclusions: There is an inverse association between MS and hepatitis B virus infection whereas the association was heterogeneous for HCV infection with a positive association with abnormal serum HDL but an inverse association with hypertriglyceridemia.

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Section: Introductionmentioning

confidence: 99%

A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10)

et al. 2006

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“…Various chronic liver diseases are associated with DM (8,9). Many studies report that HCV increases the incidence of DM (13)(14)(15)(16)(17). The hepatitis C virus induces DM through insulin resistance via a variety of direct and indirect mechanisms (12).…”

Section: Discussionmentioning

confidence: 99%

“…An estimated 1.4-46.7% of patients infected with HCV also have DM, and a meta-analysis shows HCV infection increases the risk of developing DM by approximately 1.7-fold compared to that in non-infected controls (16). Diabetes mellitus also occasionally occurs in HBV-infected patients; previous studies indicate the prevalence rate of DM is 6.3-12% in HBV infection (13)(14)(15)18). However, a recent population-based cohort study suggested that HBV infection had no effect on DM development (27).…”

Section: Discussionmentioning

confidence: 99%

“…A population-based study indicates that DM increases the overall mortality rate 2.3-30.8-fold in patients with chronic hepatitis B, alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD) (11). Although there are many reports regarding the prevalence of DM in patients with hepatitis C virus (HCV) infection (13)(14)(15)(16)(17), hepatitis B virus (HBV) infection (18), alcoholic liver disease (11,19) and NAFLD (11,20), the incidence rate of DM in AIH has not been reported. The involvement of DM in HCV-infected patients is correlated with hepatic functional reserve (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Risk Factors of Diabetes Mellitus in Patients with Autoimmune Hepatitis

et al. 2016

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Objective The administration of corticosteroids is a standard treatment for autoimmune hepatitis (AIH), but it can occasionally induce various adverse effects. Diabetes mellitus (DM) is a major complication of chronic liver diseases. We investigated the prevalence and risk factors of DM in patients with AIH. Methods We retrospectively analyzed 118 Japanese patients diagnosed with AIH from 1990 to 2014 at our institution. The prognosis of patients with and without DM was also compared. Results Twenty-nine (24.5%) patients had DM and 21 (72.4%) received corticosteroids. The annual cumulative incidence rate of newly diagnosed DM was 1.2%. Multivariate analysis showed that DM occurred in older patients [OR=6.290; 95% confidence interval (CI)=1.230-32.100; p=0.018] with higher serum immunoglobulin G levels (OR=12.400; 95% CI=2.560-60.400; p=0.002). A Cox hazard regression analysis revealed that predictive factors for DM were absence of other autoimmune diseases (OR=0.171; 95% CI=0.036-0.805; p=0.025), use of corticosteroids (OR=6.693; 95% CI=1.391-32.210; p=0.049) and lower platelet counts (OR= 3.873; 95% CI=1.021-14.690; p=0.046). The 10 year survival rates of the DM and non-DM groups were 94.1% and 94.6%, respectively. There was no significant difference between these groups (p=0.293). Conclusion DM occurred in 24.5% of patients with AIH; older age, absence of other autoimmune diseases and higher serum immunoglobulin G levels are risk factors. Taking corticosteroids and a lower platelet count are risk factors for a new onset of DM. DM did not influence the prognosis of AIH patients.

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“…ZG16p is associated with lipid microdomains ('rafts') and affects the protein synthesis and intracellular transport of secretory proteins and maturation of zymogens in ZGs [31][32][33][34] . HCV infection and chronic hepatopathy caused by HCV are significantly associated with diabetes, and reduction of glucose tolerance is related to the severity of chronic hepatitis C [35,36] . The result of our experiment showed that interaction occurred between HCV F and ZG16p, thus providing a new clue for revealing the function of HCV F protein and relationship between pathogenesis of HCV and diabetes mellitus.…”

Section: Analysis Of Cdna Sequence and Homologymentioning

confidence: 99%

Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system

Huang¹

2005

WJG

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AIM:To investigate the biological function of F protein by yeast two-hybrid system. METHODS:We constructed F protein bait plasmid by cloning the gene of F protein into pGBKT7, then recombinant plasmid DNA was transformed into yeast AH109 (a type). The transformed yeast AH109 was mated with yeast Y187 (α type) containing liver cDNA library plasmid in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium (SD/-Trp-Leu-HisAde) containing X-α-gal for selection and screening. After extracting and sequencing plasmids from positive (blue) colonies, we underwent sequence analysis by bioinformatics. RESULTS:Thirty-six colonies were selected and sequenced. Among them, 11 colonies were zymogen granule protein, 5 colonies were zinc finger protein, 4 colonies were zinc-α-2-glycoprotein, 1 colony was sialyltransferase, 1 colony was complement control protein factor I, 1 colony was vitronectin, and 2 colonies were new genes with unknown function. CONCLUSION:The yeast two-hybrid system is an effective method for identifying hepatocyte proteins interacting with F protein of hepatitis C virus. F protein may bind to different proteins.

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Prevalence of diabetes mellitus in Japanese patients infected chronically with hepatitis C virus

Abstract: Taken together, the findings indicate that cirrhosis appears to be a more important predictor of glucose intolerance than HCV infection, and the combination of both factors increases the risk of DM in our populations.

Cited by 86 publications

References 20 publications

A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10)

A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10)

Prevalence and Risk Factors of Diabetes Mellitus in Patients with Autoimmune Hepatitis

Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system

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