Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection

Calza, Leonardo; Masetti, G.; Piergentili, Benedetta; Trapani, Filippo; Cascavilla, Alessandra; Manfredi, Roberto; Colangeli, Vincenzo; Viale, Pierluigi

doi:10.1258/ijsa.2010.010256

Cited by 41 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to traditional RF for the development of diabetes including male gender, older age, BMI, African or Asian ethnicity, other HIV-related factors such as ARV (particularly exposure to older PI and thymidine analogues) and LDS are predictors of diabetes [41,90–92]. The D:A:D Study Group found that higher TG levels and low HDL were independently predictive of the development of diabetes[92].…”

Section: Pre-diabetes In Hiv-related Msmentioning

confidence: 99%

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV

et al. 2016

View full text Add to dashboard Cite

With widespread and effective antiretroviral therapy, the life expectancy in the HIV population has dramatically improved over the last two decades. Consequently, as patients are aging with HIV, other age-related comorbidities, such as metabolic disturbances and cardiovascular disease (CVD), have emerged as important causes of morbidity and mortality. An overrepresentation of traditional cardiovascular risk factors (RF), toxicities associated with long exposure to antiretroviral therapy, together with residual chronic inflammation and immune activation associated with HIV infection are thought to predispose to these metabolic complications and to the excess risk of CVD observed in the HIV population. The metabolic syndrome (MS) represents a clustering of RF for CVD that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance. Hypertension is a prevalent feature of the MS in HIV, in particular in the aging population, and constitutes an important RF for CVD. Physicians should screen their patients for metabolic and cardiovascular risk at the regular visits to reduce MS and the associated CVD risk among people aging with HIV, since many of RF are under-diagnosed and under-treated conditions. Interventions to reduce these RF can include life-style changes and pharmacological interventions such as antihypertensive and lipid-lowering therapy, and treatment of glucose metabolism disturbances. Changes in antiretroviral therapy to more metabolic neutral antiretroviral drugs may also be considered.

show abstract

Section: Pre-diabetes In Hiv-related Msmentioning

confidence: 99%

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV

et al. 2016

View full text Add to dashboard Cite

show abstract

“…al. (3) evaluated the prevalence of DM and metabolic syndrome in an observational cohort of 775 HIV-infected patients on cART seen in an Italian clinic between July-September 2009. Diabetes was diagnosed through one time fasting blood glucose >126 mg/dl, random glucose >200 mg/dl, or history of hypoglycemic medications.…”

Section: Epidemiologymentioning

confidence: 99%

Diabetes Mellitus Type 2 and Abnormal Glucose Metabolism in the Setting of Human Immunodeficiency Virus

Hadigan

Kattakuzhy

2014

Endocrinology and Metabolism Clinics of North America

View full text Add to dashboard Cite

Article Synopsis As the modern era of combination antiretroviral therapy has increased life expectancy for HIV infected individuals, Type II Diabetes Mellitus (DM) and disorders of glucose metabolism have emerged as an important issue in the care of this population. Multiple mechanisms, both specific and nonspecific to HIV, underlie a significant prevalence. While best practice diagnostic testing remains unclear, the risks associated with diabetes in the setting of HIV are well characterized, ranging from organ-specific damage to socioeconomic decline. Population specific treatment data is limited, and thus current guidelines serve as a basis for ongoing management.

show abstract

“…Lipodystrophy syndrome has been reported in as many as 41% of people with HIV and comprises changes in body fat distribution including both fat loss (lipoatrophy) and fat accumulation (lipohypertrophy) [26]. Combined ART can cause mitochondrial toxicity and dysfunction and may be a cause of adverse metabolic effects such as lipodystrophy and insulin resistance.…”

Section: Lipodystrophymentioning

confidence: 99%

Hypogonadism in Human Immunodeficiency Virus-Positive Men

2014

View full text Add to dashboard Cite

In recent years, the life expectancy for those living with human immunodeficiency virus (HIV) with access to combined antiretroviral therapy (cART) has increased. As men live longer, the role testosterone plays in sexual function as well as in general well-being is becoming increasingly important. Here we discuss the available literature concerning androgens and HIV disease. A review was undertaken by using a PubMed search with the umbrella terms HIV or AIDS and testosterone or androgens spanning 1985 to 2011. Significant articles found in references in the primary search were also included. The reported prevalence of androgen deficiency appears to be greater in HIV-infected males than in the general population. Androgen deficiency is usually associated with low luteinizing hormone and follicle-stimulating hormone and is sensitive to the type of measurement of testosterone used. Rates of hypogonadism may be falling since the advent of cART. Causes of low testosterone levels have been attributed to chronic illness, HIV replication, cART, opportunistic infections, comorbidities and coinfections, wasting, and normal age-related declines. Studies of testosterone treatment in HIV-positive men are lacking in standardization and outcome measures.

show abstract

Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection

Cited by 41 publications

References 18 publications

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV

Diabetes Mellitus Type 2 and Abnormal Glucose Metabolism in the Setting of Human Immunodeficiency Virus

Hypogonadism in Human Immunodeficiency Virus-Positive Men

Contact Info

Product

Resources

About