Prevalence of diabetes mellitus and prediabetes in the adult <scp>R</scp>omanian population: <scp>PREDATORR</scp> study

Moța, Maria; Popa, Simona; Moţa, E; Mitrea, Adina; Catrinoiu, Doina; Cheţa, D; Guja, Cristian; Hâncu, Nicolae; Ionescu-Tîrgovişte, C; Lichiardopol, Radu; Mihai, Bogdan; Popa, Amorin Remus; Zetu, Cornelia; Bala, Cornelia; Román, Gabriela; Serafinceanu, Cristian; Şerban, Viorel; Timar, Romulus; Vereşiu, Ioan Andrei; Vlad, Adrian

doi:10.1111/1753-0407.12297

Cited by 122 publications

(113 citation statements)

References 15 publications

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“…Yet, the first large scale national study on the prevalence of DM conducted in Romania recorded a different prevalence rate than the one included in the WHO latest Global Report on Diabetes [2]. Thus, in the PREDATORR study (PREvalence of DiAbeTes mellitus, prediabetes, overweight, Obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romania), the age-and sex-adjusted prevalence of DM was 11.6% (95% CI 9.6%-13.6%) [3]. PREDATORR study showed an increased prevalence of diabetes and prediabetes in Romania, almost double compared to the previous estimations [4].…”

mentioning

confidence: 99%

Health Related Quality of Life of Patients with Diabetes in Romania

Iamandi-Cioinaru

Corad

Marín³

et al. 2017

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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confidence: 99%

Health Related Quality of Life of Patients with Diabetes in Romania

Iamandi-Cioinaru

Corad

Marín³

et al. 2017

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…(19). More than 20 years ago, Allison et al, demonstrated that T2DM was more frequent in HCV liver cirrhosis compared with other etiologies (20).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Genotype 1 Virus C Compensated Liver Cirrhosis in the Era of Directly Acting Antiviral Therapy

et al. 2017

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Objectives: The current study aimed at evaluating the association between metabolic syndrome (MeS) in patients with hepatitis C virus (HCV) liver cirrhosis (compensated, genotype, 1b) and changes after sustained viral response (SVR) following a 12-week therapy with paritaprevir, ritonavir, ombitasvir, dasabuvir, and ribavirin (PrOD+R). Methods: The current multicenter retrospective study included 809 patients diagnosed with compensated HCV cirrhosis (child class A), all 1b genotype treated for 12 weeks with direct acting antiviral agents -PrOD+R -regimen (according to the protocol practiced in Romania) and achieved SVR. The parameters of MeS (according to the definition of the International Diabetes Federation) were collected from medical records before and 12 weeks after the treatment. The results were collected in a central database and analyzed with SPSS 18.0. Statistical analysis used both descriptive and analytical methods with a significance level of 95% (CI 95%). Results: Out of the 809 patients, 105 (13%) demonstrated 3 out of the 5 criteria for MeS. Based on the MeS criteria, the commonest parameters were abnormal glycaemia (54.1%), followed by visceral obesity (38.6%), raised triglycerides (26.1%), high blood pressure (12.1%), and a low high-density lipoprotein (HDL)-cholesterol (4.6%). The re-assessment of MeS parameters after SVR showed favourable changes, which were statistically significant: a siginficanttly lower serum triglyeride level (182.32 vs. 153.50 mg/dL, P = 0.001), lower systolic arterial blood pressure (130.57 vs. 124.85 mmHg; P = 0.001), lower diastolic arterial blood pressure (80.26 vs. 78.42 mmHg; P = 0.001) and lower glyceamic levels (130.06 vs. 120.71 mg/dL; P = 0.001), as well as a significant rise in HDL-cholesterol levels (48.61 vs. 50.50 mg/dL; P = 0.003). Abdominal circumference was the only parameter, which did not change after SVR. Following the changes sustained after SVR, 26.7% of the patients no longer fulfilled the minimum 3 criteria for MeS. No correlation was observed between the presence of MeS and the risk of severe adverse events, but it was noted that 37.5% of the patients who decompensated, 66.7% of the ones who developed hepatocarcinoma and 100% of the ones that died of abnormal glycaemic levels. Conclusions: Hyperglycemia, and not MeS, is associated with HCV compensated liver cirrhosis genotype 1b, and is a risk factor for severe adverse events. The attainment of SVR through PrOD+R regimen results in short-term improvements in MeS parameters.

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“…In 2011, Bartoş and Bădilă found a prevalence of 10.3% for diabetes [19]. The PREDATORR (PREvalence of DiAbeTes mellitus, prediabetes, overweight, Obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romania) study has shown an overall age-and sex-adjusted prevalence of diabetes in the general adult Romanian population of 11.6% (95%CI 9.6%-13.6%) [30]. In a study conducted in Slovakia, the prevalence of type 2 diabetes in Roma population was 30% versus 10% in the control population, obesity 65% (vs. 30% in controls) and metabolic syndrome 20% versus 4% in controls [22] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Obesity and Newly Diagnosed Diabetes in the Roma Population from a County in the South Part of Romania (Călăraşi County) -Preliminary Results

Enache

Rusu

Ilinca³

et al. 2016

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Prevalence of diabetes mellitus and prediabetes in the adult Romanian population: PREDATORR study

Abstract: The PREDATORR study shows a high prevalence of impaired glucose regulation in the adult Romanian population, providing data on the prevalence of DM and prediabetes and their association with several risk factors.

Cited by 122 publications

References 15 publications

Health Related Quality of Life of Patients with Diabetes in Romania

Health Related Quality of Life of Patients with Diabetes in Romania

Metabolic Syndrome and Genotype 1 Virus C Compensated Liver Cirrhosis in the Era of Directly Acting Antiviral Therapy

Prevalence of Obesity and Newly Diagnosed Diabetes in the Roma Population from a County in the South Part of Romania (Călăraşi County) -Preliminary Results

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