Prevalence of diabetes in chronic liver disease patient admitted in medicine ward in RIMS Hospital, Imphal

Perme, Obang; Singh, Y Ibotomba; Singh, Khushwant; Devi, Bhagyabati; Rao, Aksay; Singh, Satnam

doi:10.4103/0972-4958.182906

Cited by 2 publications

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“…21 Seventy percentage were alcohol related in entire liver diseases in a study conducted by Perme et al, in North-East India which was followed by viral etiology in 29%. 22 Similar alcohol predominance is reported by Ray in Eastern India. 23 Seventy three (92.4%) of the total 79 patients were having low bone mineral density in which 36.7% were having osteopenia and remaining 55.7% were having osteoporosis.…”

Section: Resultssupporting

confidence: 72%

A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

et al. 2020

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Background: Hepatic osteodystrophy encompasses the spectrum of metabolic bone diseases in chronic liver disease (CLD) patients. CLD causing changes in BMD is well known. Although BMD evaluation in CLD cirrhosis are recommended by societies of British and American gastroenterology ,very less number of literature exist from India and none from the North-eastern region of India. Aim of the study to determine the association and severity of bone mineral density changes in patients with CLD and to correlate it with different aetiologies and severity of CLD.Methods: This cross-sectional study which included 79 patients with CLD was conducted in RIMS, Manipur from September 2017 to August 2019. All CLD patients of age 18-60 years were included. DEXA scan and other related blood investigations were performed.Results: Chronic alcohol intake (56.9%), viral infection (20.3%) and mixed (17.7%) were the main aetiology of CLD in our study. Seventy three (92.4%) of the total 79 patients had low BMD (Osteopenia in 29 (36.7%) and osteoporosis in 44 (55.7%) patients). Osteoporosis was detected in 53.4% of alcohol related Cirrhosis, 25%of viral liver disease. Majority of the severe CLD patients (Child class C) had osteoporosis (70.6%) as compared to less severe groups (23.5% and 36.4% in class B and A respectively).Conclusions: CLD patients have high prevalence of osteoporosis. Severity of liver disease, alcoholic liver disease, serum calcium and vitamin D deficiency predisposes to osteoporosis in these patients. Hence early screening of BMD is necessary in CLD patients.

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Section: Resultssupporting

confidence: 72%

A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

et al. 2020

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“…Another cross-sectional study reported HD in 12.5% patients with cirrhosis while glucose intolerance accounted for 21.6% [24]. An Indian study found 12.9% prevalence of diabetes in patients with CLD and higher mortality (20.0%), compared to non-diabetic patients with CLD [25].…”

Section: Chronic Liver Diseases and Diabetes Mellitus: A Viscious Cyclementioning

confidence: 99%

A Review on the Role of Low Glycemic Index Foods for Glycemic Control in Chronic Liver Disease

Bhoite¹,

Joshi²,

Pratti³

et al. 2023

FNS

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Liver is an essential organ that maintains fasting and postprandial blood glucose response via various metabolic pathways. The liver function gradually deteriorates in chronic liver disease (CLD) due to inflammation and destruction of liver parenchyma. The development of glucose intolerance and hepatogenous diabetes (HD) in patients with CLD is an inevitable event. Diabetes and CLD can coexist, and function synergistically to cause unfavorable clinical consequences, including poor treatment outcomes and frequent hospitalization. The complications associated with liver disease (malnutrition, hypoglycemia, acute kidney injury, lactic acidosis, etc.) and lack of guidelines limit pharmacological management of HD. Dietary recommendations by The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines (2019), suggested weight reducing hypocaloric diet along with adequate branched-chain amino acid (BCAA) and micronutrient consumption to improve steatosis and insulin sensitivity in patients with CLD. Dietary glycemic index controls prognosis of obesity, non-alcoholic fatty liver disease (NAFLD) and diabetes. The importance of low GI diet in reducing fasting blood glucose, hepatic glucose influx and fat accumulation, thereby improving weight loss and NAFLD score, is being published in patients with diabetes or liver disease. Several countries have already incorporated GI into their national health policies, for identification of the nutrient value, resulting in establishment of worldwide GI and glycemic load tables for specific food items. However, the apparent complexity of GI and lack of low GI meal choices need to be resolved in order to enhance patient's quality of life, health and well-being. Low GI nutritional supplements, comprising of balanced proportion of carbohydrate, protein, BCAAs, fibers and micronutrients, may reduce the complexity related to dietary management of HD. The review summarizes the importance of nutritional management in HD with focus on low GI diet in people with CLD.

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Prevalence of diabetes in chronic liver disease patient admitted in medicine ward in RIMS Hospital, Imphal

Cited by 2 publications

References 0 publications

A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

A cross-sectional study of chronic liver disease patients complicating to hepatic osteodystrophy

A Review on the Role of Low Glycemic Index Foods for Glycemic Control in Chronic Liver Disease

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