Physicians are rightfully proud of their reputation as being intelligent, dedicated, hard-working, committed to the lifelong acquisition of new knowledge and skills, and able to overcome personal discomfort (particularly sleep deprivation) for the sake of the needs of patients. Physicians are less proud and less willing to admit or discuss that, as a profession, they are at equal risk for depression and higher risk for suicide than that of the general population, 1-3 despite having seemingly better access to mental health care than many segments of the population.The literature describing the risk of depression and suicide in medical students is relatively rich 4 and somewhat so for practicing physicians. [1][2][3]5 Studies of depression among physicians in training (residents and fellows) are less common, perhaps because residents in general are busier, more overwhelmed, more fatigued, more sleep deprived than either medical students or practicing physicians, and less accessible for surveys and interviews. The reasons that depression risk among physicians in training is more difficult to study may be the very reasons they are more vulnerable to that risk.In this issue of JAMA, the study by Mata and colleagues 6 fills that gap to a considerable extent with a meta-analysis of 31 cross-sectional and 23 longitudinal studies of depression among physicians in training. The results are discouraging: the prevalence of depression or depressive symptoms ranged from 20.9% to 43.2%, depending on the nature of the assessment. This systematic review makes it clear that the medical profession has a major problem. What is the profession willing and able to do about it?The 54 studies identified by Mata et al 6 mostly used validated self-report questionnaires to assess either depression or depressive symptoms. These questionnaires, plus the structured interviews used in 3 studies, are highly heterogeneous in their construction, symptoms measured, and criteria used, with a wide range of resultant operating characteristics. The authors addressed this problem with appropriate groupings of instruments that perform in similar ways. In any case, the subtle methodologic complexities of this systematic review pale in comparison with the fundamental finding that the extent of depressive symptoms in physicians in training is extraordinarily high. Roughly a quarter to a third of physicians in training reported experiencing significant depressive symptomatology, if not overt clinical depression, at any point in time. The