Prevalence of depression and anxiety among drug resistant tuberculosis: A study in North India

G, Srinivasan; Chaturvedi, Deepanshi; Verma, Divyanshu; Pal, Hemlata; Khatoon, Heena; Yadav, Deepika; Sahil, Abhishek Pratap; Gautam, Deepanshi; Deepak, Desh

doi:10.1016/j.ijtb.2021.04.010

Cited by 12 publications

(6 citation statements)

References 18 publications

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“…In the present study, more than half (52.1%) of the patients showed depression or/and anxiety to varying degrees, similar to most studies with a prevalence ranging from 40 to 60% ( 29 – 31 ); however, < 60–80% of multidrug-resistant and extensively drug-resistant TB ( 32 ). Previous research has shown that Mtb infection and mental illness can interact, with an underlying biopsychosocial mechanism that comprises biological factors like the inflammatory cascade and psychosocial factors like perceived stigma ( 33 ).…”

Section: Discussionsupporting

confidence: 89%

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Liu

Bai²,

Ren³

et al. 2022

Front. Psychiatry

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BackgroundDepression and anxiety are major psychological issues among patients with tuberculosis (TB) owing to chronic and complex treatments, have been reported to be closely correlated with immune and inflammation. However, the association of peripheral immune-inflammatory characteristics with depression/anxiety symptoms in in-patients with TB has rarely been reported.MethodsA cross-sectional study of 338 in-patients with TB from 3 hospitals in China were enrolled to investigate their depression and anxiety status by using the nine-item Patient Health Questionnaire (PHQ-9) and seven-item Generalized Anxiety Disorder Scale (GAD-7). Participants were divided into groups based on their PHQ-9 and GAD-7 scores, and differences in demography and immune-inflammatory characteristics were studied. Logistic analysis was performed to explore factors related to depression and anxiety symptoms.ResultsDepression and anxiety prevalence among patients with TB was 47.9 and 42.6%, respectively. Furthermore, 38.5% of patients reported a comorbidity of depression and anxiety symptoms. The counts of CD3, CD4, CD8, and lymphocytes decreased, whereas those of neutrophils, platelets, and peripheral blood cells and their derived indices increased among TB patients with depression or anxiety in comparison with those without symptoms (p < 0.05). In addition, increasing age, lower income (monthly income ≤ 3,000 yuan), divorced or widowed, drug resistance, and higher systemic immune inflammation index (SII) were significantly associated with depression or anxiety symptoms (p < 0.05).ConclusionApproximately half of the patients with TB suffered from depression or/and anxiety symptoms. Patients with depression or anxiety present worse cell immune status and stronger inflammatory responses compared to those without symptoms. We emphasized the importance of paying attention to the dysfunction of immune-inflammation process of TB patients with depression or anxiety symptoms. Especially, SII has a potential application value in guiding the evaluation of TB-related depression or anxiety owing to its easily accessibility and being economical.

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Section: Discussionsupporting

confidence: 89%

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Liu

Bai²,

Ren³

et al. 2022

Front. Psychiatry

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“…This wide variation, globally and locally, is not surprising concerning the use of different instruments, and cut-off points for defining depression, disease stages, treatment stages, and other differences in study settings. Regarding anxiety, previous global studies show different prevalences ranging from 12%--54% [ [27] , [28] , [29] , [30] ]. In Indonesia, Fitrianur, Soeharto, and Supriati [ 31 ] found a 62% prevalence of anxiety in a hospital-setting population in East Java.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression level of patients with multidrug-resistant tuberculosis (MDR-TB) in two hospitals in Banten province, Indonesia

Susanto

Widysanto

Cipta

et al. 2023

Dialogues in Health

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“…MDR-TB patients undergoing individual regimens are more likely to experience anxiety due to the long (20 months) and intense treatment. 23 Individual regimens consist of potent anti-TB drugs with severe side effects, higher case fatality rates, and lower cure rates. 22 Additionally, a qualitative study in Thailand revealed that 5 out of 12 MDR-TB patients undergoing individual treatment experienced anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…For each question or statement, respondents are asked to provide the severity of the symptoms they experience, with a rating scale ranging from 0 to 4. The ratings are then used to calculate the total anxiety score, which is divided into five levels, no anxiety (<14), mild anxiety (14-20), moderate anxiety (21)(22)(23)(24)(25)(26)(27), severe anxiety (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41), and very severe anxiety (>41). A higher score indicates a higher level of anxiety.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Anxiety Levels in MDR-TB Patients with Individual and Short-term Regimens at Dr. Soebandi Regional General Hospital, Jember, Indonesia

Widodo,

Astuti,

Kusumastuti

et al. 2024

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Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a form of TB that shows resistance to both isoniazid and rifampicin. Globally, the number of new MRD-TB cases has continued to rise since 2020. Indonesia is positioned among the top ten countries with the highest incidence of MDR-TB worldwide. Specifically, Jember ranked second in the number of MDR-TB cases in East Java. This study aimed to assess the comparison between the administration of individual MDR-TB regimens and short-term regimens concerning anxiety levels in MDR-TB patients at Dr. Soebandi Regional General Hospital, Jember. Methods: This was an analytical observational study with a cross-sectional design. It was conducted at Dr. Soebandi Regional General Hospital, Jember, using interviews and medical record data from August to September 2023. The sample size was 69 participants, who were obtained through consecutive sampling. Analysis was performed using the Statistical Package for the Social Sciences (SPSS) and the Chi-Square test for group comparisons. Results: This study found that 64% of subjects received individual regimens. In the individual regimen group, 80% of subjects reported anxiety. Among the short-term regimen group, 60% of subjects showed no anxiety. The significance value of this study was 0.007 in the Chi-Square test for group differences. Conclusion: There was a difference in anxiety levels between individual and short-term regimens among MDR-TB patients at Dr. Soebandi Regional General Hospital, Jember. Patients with anxiety were more common in individual regimens compared to short-term regimens.

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Prevalence of depression and anxiety among drug resistant tuberculosis: A study in North India

Cited by 12 publications

References 18 publications

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: A cross-sectional study

Anxiety and depression level of patients with multidrug-resistant tuberculosis (MDR-TB) in two hospitals in Banten province, Indonesia

Comparison of Anxiety Levels in MDR-TB Patients with Individual and Short-term Regimens at Dr. Soebandi Regional General Hospital, Jember, Indonesia

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