Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan

Eldigail, Mawahib; Adam, Gamal K.; Babiker, Rabie Ali; Khalid, Fatima; Adam, Ibrahim; Omer, O. H.; Ahmed, Mohamed E.; Birair, Sara L.; Haroun, E. M.; Abu‐Aisha, Hassan; Karrar, A. E.; Abdalla, Hamid S.; Aradaib, Imadeldin E.

doi:10.1186/s12889-018-5853-3

Cited by 26 publications

(36 citation statements)

References 32 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is in agreement with findings reported in Djibouti, 21.8% [23] and in Northern Province of Sudan, 24% [24]. However, the observed rate of DENV exposure was lower than results in Dire Dawa, 56.8% [8], northern Ethiopia, 33.3% [3], Eritrea, 33.3%[25], Kassala, Eastern Sudan, 71.7% [26], and El Gadarif state, Sudan, 47.6% [27]. In contrast, the prevalence of anti-DENV IgG exposure in this study was higher compared to the rates 7.7% and 12.5% in Tanzania and Kenya respectively [28, 29].…”

Section: Discussionmentioning

confidence: 90%

Serological evidence of dengue fever and associated factors in health facilities in Borena Zone, Southern Ethiopia.

Geleta

2018

Preprint

View full text Add to dashboard Cite

8Background: Dengue fever is a re-emerging public health threat in Ethiopia. Yet, little is 9 known about the epidemiology and risk factors. In this study the seroprevalence and associated 10 risk factors of dengue virus infection were assessed in Borena Zone health facilities. 11Methods: An institution based cross-sectional study was conducted from May to August, 2016. 12 A total of 519 consecutive acute febrile patients attending the outpatient departments of Teltelle 13 health Center, Yabello and Moyale Hospital were enrolled. Data on socio-demographic and 14 environmental risk factors were collected using structured questionnaire. Three to five milliliter 15 blood samples were collected from all participants and screened for dengue virus exposure using 16 indirect immunofluorescent assay. 17Result: The overall prevalence of anti-DENV IgG and IgM was 22.9% and 7.9% respectively. 18The relatively higher IgM versus IgG, absence of trend with age and little or no correlation with 19 the assessed possible risk factors except being male (AOR=1.72; 95%CI 1.01-2.94), place of 20 residence (AOR=0.37;95%CL 0.21-0.64) that had higher rate of exposure and recall of a recent 21 mosquito bite (AOR=2.98; 95%CI 1.51-5.89) probably imply recent and/or ongoing active 22 transmission. 23Conclusion: This study showed dengue fever could potentially emerge as public health threat in 24 the study area. On top, the observed low awareness of participants underline the urgent need for 25 further systematic studies to determine the environmental, and host factors that determine the 26 extent of exposure to dengue virus infection in the area for appropriate control and prevention 27 planning. 28 Author summary 30 Dengue fever is a mosquito-borne viral disease of global health problem where Aedes aegypti 31 mosquitoes are the main vector. It is endemic in most tropical and sub-tropical countries with an 32 estimated 96 million infections resulting in clinical disease annually. It is unrecognized and 33 underreported in Africa, particularly in Ethiopia. So, the current study were conducted among 34 febrile patients who were attending health institutions to document seroprevalence and 35 associated risk factors of DENV infection in the southern part of the country. The study stated 36 the presence of antibodies against DENV infection in study areas, the ringing bell message for 37 those who were involved in health sectors. Gender and residence were significantly associated 38 with the prevalence of anti-DENV IgG seropositivity. In addition, individuals who have 39 experience of recent mosquito bite were identified as the risk factors of DENV infection. 40 Therefore, I recommend that preventive measures should be considered and nationwide 41 surveillance should be carried out at nationwide. 42 Introduction 43 Dengue fever (DF) is the most rapidly spreading mosquito-borne disease and the major public 44 health problem on the world [1]. Dengue is a viral disease caused by dengue virus serotypes 45 (DENV1-4) of the genus Flavivirus. Dengu...

show abstract

Section: Discussionmentioning

confidence: 90%

Serological evidence of dengue fever and associated factors in health facilities in Borena Zone, Southern Ethiopia.

Geleta

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…The PCR reveals negative results. Although not all these viruses were responsible for VHF, we screening these viruses due to many studies were conducted in eastern Sudan revealed the presence of highly seropositive of dengue and HEV [33,[43][44][45]. Thirteen patients were positive for dengue IgM in ELISA, although the PCR results for all DFV types were negative, which may be explained by the presence of several genetically and antigenically different serotypes of the DFV worldwide [6,7,43,[46][47][48].…”

Section: Discussionmentioning

confidence: 98%

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan

Mohamed

Magzoub

Mohamed

et al. 2019

Libyan Journal of Medicine

View full text Add to dashboard Cite

Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Frequent unknown fever outbreaks have been reported in eastern region, Sudan. However, diagnosis was based exclusively on clinical signs and symptoms without confirmatory laboratory investigations. However, for accurate detection of these viruses in outbreaks, molecular technique is considered. The objective of this study was to determine the prevalence of six arboviruses in the Kassala state of east Sudan during unknown fever outbreak. A cross sectional hospital-based study was conducted in the Kassala, Teaching Hospital. Blood samples from 119 patients suffering from unknown fever were used for screening of six arboviruses, hepatitis E virus and malarial using molecular techniques and serology. The overall arboviruses seroprevelance was 61.3% (73/119). The highest positivity rate was 73.1% (52/73) chikungunya virus; 29 males and 20 females patients were chikungunya positive. Other arboviruses were circulating in low rate 20.5% (15/73), and 6.8% (5/73) for sindbis and rift valley fever viruses respectively. Hepatitis E virus was negative in all cases and malaria positivity rate 13.4% (16/119). The prevalence of arboviruses among unknown fever patients present to Kassala teaching hospital of eastern region in Sudan is significantly high (61.3%). The chikungunya virus is the predominant causative agent of arboviruses. Molecular techniques such as PCR are important for accurate and rapid diagnosis of this viral outbreak.

show abstract

“…However, an association between the male gender and DENV infection has been described by the Ghanaian authors. These contradictory findings are also described in non‐blood donors …”

mentioning

confidence: 82%

“…These contradictory findings are also described in non-blood donors. 8,13,32,34 In Burkina Faso, very few studies on DENV in blood donors has been conducted in 2003. 35 This study reported a higher prevalence of DENV infection among blood donors in rural areas than in urban areas (34.8% vs 30.4%).…”

Section: This Recent Rapid Expansion Throughout the World And In Burkinamentioning

confidence: 99%

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Sawadogo

Baguiya

Yougbare

et al. 2019

Transfusion Medicine

View full text Add to dashboard Cite

Summary Objectives Our study aimed to update the seroprevalence and factors associated with anti‐dengue virus (DENV) antibody positivity among blood donors and to discuss their implications for blood supply. Background Questions on the potential transmission of DENV by transfusion increased after the documentation of the risk of transmission of the West Nile virus. This risk was estimated after transfusion of DENV RNA‐positive blood units of up to 37.5%. In Burkina Faso, very few studies on DENV in blood donors have been conducted. As a result, there were no reliable data on DENV to allow the implementation of appropriate measures to control the risk of transmission of the dengue virus by blood transfusion. Methods We conducted a 4‐week cross‐sectional study from December 4 to 30, 2016. Blood donors of both genders, aged 18‐60 years, accepted for blood donation after medical selection were consecutively enrolled. Results Our study included a total of 1007 blood donors, in which donors living in urban areas represented 78.2%. The mean age was 26.1 ± 8.1 years. After adjustment in a multiple regression logistic model, the odds of having IgG anti‐DENV increased as age increased. The odds of DENV was 53% lower in rural areas (OR = 0.47; P = .000) compared to urban settings and 42% lower in mobile sites (OR = 0.58; P = .03) compared to fixed ones. Conclusion Our study provides new and useful insights for future research on the risk of TT‐DENV throughout blood transfusion.

show abstract

Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan

Cited by 26 publications

References 32 publications

Serological evidence of dengue fever and associated factors in health facilities in Borena Zone, Southern Ethiopia.

Serological evidence of dengue fever and associated factors in health facilities in Borena Zone, Southern Ethiopia.

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Contact Info

Product

Resources

About