Prevalence of Dengue, Chikungunya, and Zika Viruses in Febrile Pregnant Women: An Observational Study at a Tertiary Care Hospital in North India

Abstract

Dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) are arboviruses that can affect maternal and fetal outcome if acquired during pregnancy. This study was done to estimate the positivity of DENV, CHIKV, and ZIKV in febrile pregnant women attending a tertiary care hospital in north India. Symptomatic pregnant women were tested for these viruses by IgM ELISA and/or by Trioplex real-time polymerase chain reaction. Their symptoms and laboratory parameters were recorded and were followed up till delivery to know their immediate delivery outcome. Of 104 women tested, 50 (48.1%) were positive for viral markers. Of these, evidence of infection by DENV, CHIKV, and both was found in 34 (32.7%), 10 (9.6%), and 6 (5.8%), respectively. ZIKV was not detected in any woman. Maximum DENV positivity occurred in the third trimester of pregnancy and in women residing in urban than rural areas. Chills and rigors, arthralgia, retro-orbital pain, anemia, and vaginal bleeding were more commonly associated with DENV positivity. Backache, arthralgia, jaundice, and vaginal bleeding were more common in CHIKV positives but the difference between positives and nonpositives regarding these symptoms was not statistically significant. Dengue infections were associated with more frequent hospitalizations (OR = 8.38, 95% confidence intervals [CI] = 3.29–21.30) and mortality (OR = 19.0, 95% CI = 1.01–357.10). Hence, to conclude, in India wherever possible, all symptomatic pregnant women should be screened for DENV, CHIKV, and ZIKV as part of sentinel surveillance for ZIKV.

Maternal and foetal‐neonatal outcomes of dengue virus infection during pregnancy

“…After taking into account titles and abstracts, 852 articles were eliminated, leaving 68 articles for review and potential consideration in this study (Figure 1). Ultimately, 36 articles reporting on 39,632 DENV‐infected pregnant women were included in this meta‐analysis, 6–8,14–46 comprising 18 from Asia (mostly from India, n = 12), 15 from Latin America and 3 from Africa (Table 1).…”

Complicações da infecção pelo vírus da Dengue em gestantes

“…em gestantes com diagnóstico de dengue do que em gestantes saudáveis. 18 3.2 COMPLICAÇÕES E DENGUE HEMORRÁGICA Brar et al, 2021 relatou que 50% das gestantes apresentaram algum sinal de alarme para dengue durante a admissão, sendo o mais comum êmese relatado em 47,5% das gestantes analisadas. 17 O estudo de Mulyana et al, 2020 também relatou alta incidência de sinais de alarme para dengue (53,7% das gestantes).…”

“…Gupta et al, 2021 relatou probabilidade superior a de hospitalização quando comparado gestante com e sem o diagnóstico de dengue (OR 8,38 [IC 95% 3,29-21,30). 18 O estudo de Nascimento et al, 2017 ao analisar as gestantes brasileiras com diagnóstico de dengue constatou taxa de hospitalização de 5,4%. 21 Martin et al, 2022 corroborou com os dados ao analisar os dados de Sistema de Informação de Agravos de Notificação (SINAN) as informações sobre dengue em gestantes e não gestantes.…”

Importation of a novel Indian Ocean lineage carrying E1-K211E and E2-V264A of Chikungunya Virus in Zhejiang Province, China, in 2019

“…Other common signs and symptoms include myalgias, joint swelling, headaches, nausea, severe fatigue, and maculopapular skin [ 11 ]. However, several clinical symptoms of CHIKV infection overlap with those of dengue virus (DENV) and Zika virus (ZIKV) infections [ 12 ].…”