Prevalence of Dementia in People Aged 60 Years and Above: Results from the WiSE Study

Subramaniam, Mythily; Chong, Siow Ann; Vaingankar, Janhavi Ajit; Abdin, Edimansyah; Chua, Boon Yiang; Chua, Hong Choon; Eng, Goi Khia; Heng, Derrick; Hia, Soo Boon; Huang, Wanping; Jeyagurunathana, Anitha; Kua, Joshua; Lee, Siau Pheng; Mahendran, Rathi; Magadi, Harish; Malladi, Srinivasa; McCrone, Paul; Pang, Shirlene; Picco, Louisa; Sagayadevan, Vathsala; Sambasivam, Rajeswari; Seng, Kok Han; Seow, Esmond; Shafie, Saleha; Shahwan, Shazana; Tan, Lay Ling; Yap, Mabel; Zhang, Yunjue; Ng, Li Ling; Prince, Martin

doi:10.3233/jad-142769

Cited by 133 publications

(148 citation statements)

References 24 publications

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“…The collection of research data without participant’s identifiers such as name, and other identifiable data further ensured confidentiality . The study method has been described in detail elsewhere [32]. …”

Section: Methodsmentioning

confidence: 99%

“…It has a multiethnic urban population comprising Chinese, Malays and Indians as well as those belonging to other ethnicities. A recent study in Singapore [32] examined the risk factors of dementia and identified that older age, lower education, homemaker and retired status, and a history of stroke diagnosis were associated with a higher risk of dementia. Although various studies have demonstrated possible modifiable health and lifestyle risk factors of dementia, few studies have examined the pathways of how these factors influence each other as mediators and moderators that subsequently lead to dementia.…”

Section: Introductionmentioning

confidence: 99%

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The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population

et al. 2017

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BackgroundOur study aimed to investigate the pathways by which socio-demographic factors, modifiable health and lifestyle risk factors influence each other, and subsequently, lead to dementia.MethodsWe used data from the Well-being of the Singapore Elderly study, a nationally representative survey of the older adult population aged 60 years and above in Singapore. Dementia diagnosis was established using 10/66 dementia criteria. Structural equation modelling (SEM) without latent variable was applied to confirm the hypothesized model.ResultsThe results of SEM supported the hypothesized model (χ 2 = 14.999, df = 10, p = 0.132). The final model showed that those aged 75–84 years and 85 years and over (vs. 60–74 years), having no formal education, who had completed primary or secondary education (vs. completed tertiary), who were homemakers and retired (vs. paid work), and with a history of stroke were directly associated with higher odds of having dementia, while those who had more frequent contact with friends and neighbors as well as being physically active were directly associated with lower odds of having dementia diagnosis. The study also found that physical activity, more frequent contact with friends and stroke played a significant role as mediators in these relationships. The overall pathways model explained 57.7% of the variance in dementia.ConclusionOur results suggest that physical activity, social contact and stroke were potential mediators in the relationship between age, education, employment and dementia. Intervention programmes focusing on physical activity such as exercise and social contact may be useful in reducing the risk of dementia among older adults.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population

et al. 2017

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“…These disorders were chosen for three main reasons. First, these disorders were previously explored in local epidemiological studies and were identified as common disorders in Singapore -major depressive disorder, alcohol abuse and OCD being the top three most common disorders and dementia having a prevalence of 10% in the older adult population (Chong et al 2012c;Subramaniam et al 2015). Second, these disorders were associated with large treatment gaps (Chong et al 2012a, b).…”

Section: Introductionmentioning

confidence: 99%

The Singaporean public beliefs about the causes of mental illness: results from a multi-ethnic population-based study

Pang

Subramaniam

Lee

et al. 2017

Epidemiol Psychiatr Sci

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Aims. To identify the common causal beliefs of mental illness in a multi-ethnic Southeast Asian community and describe the sociodemographic associations to said beliefs. The factor structure to the causal beliefs scale is explored. The causal beliefs relating to five different mental illnesses (alcohol abuse, depression, obsessive-compulsive disorder (OCD), dementia and schizophrenia) and desire for social distance are also investigated.Methods. Data from 3006 participants from a nationwide vignette-based study on mental health literacy were analysed using factor analysis and multiple logistic regression to address the aims. Participants answered questions related to sociodemographic information, causal beliefs of mental illness and their desire for social distance towards those with mental illness.Results. Physical causes, psychosocial causes and personality causes were endorsed by the sample. Sociodemographic differences including ethnic, gender and age differences in causal beliefs were found in the sample. Differences in causal beliefs were shown across different mental illness vignettes though psychosocial causes was the most highly attributed cause across vignettes (endorsed by 97.9% of respondents), followed by personality causes (83.5%) and last, physical causes (37%). Physical causes were more likely to be endorsed for OCD, depression and schizophrenia. Psychosocial causes were less often endorsed for OCD. Personality causes were less endorsed for dementia but more associated with depression.

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“…The decline in cognitive functions, especially learning and memory deficits, is prevalent among older adults, which results in degraded quality of life for them [1,2]. Therefore, how to slow down the impairments of learning and memory in the aging process to promote the development of cognitive function is one of the goals of public health.…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise ameliorates learning and memory deficits of aging rats induced by D-galactose via promoting SYP and BNDF expression in hippocampus

Zhang

Yuan

2017

BIO Web Conf.

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Abstract. The aim of this study was to explore the effects of aerobic exercise on learning and memory of aging brain and the underlying potential mechanism. We adopted the method of intraperitoneal administration for 6 weeks to induce aging rat model and gave rats swimming exercise intervention in the process of aging modeling. Then the Morris Water Maze test, immunofluorescence, western blotting and real time PCR technology were adopted to estimate rats' learning and memory abilities and the expression levels of BDNF and SYP in hippocampus respectively. Compared with the aging model rats induced by D-gal administration, the rats subjected to swimming exercise in the process of aging modeling showed not only faster acquisition and better retention of the maze but also higher expression levels of BDNF and SYP in hippocampus. These findings provide evidence that aerobic exercise could ameliorate learning and memory deficits of aging rats induced by D-gal, which is related to aerobic exercise' promoting hippocampal BNDF and SYP expression.

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Prevalence of Dementia in People Aged 60 Years and Above: Results from the WiSE Study

Abstract: The establishment of accurate data on the number of people with dementia is essential in the planning of services and initiatives.

Cited by 133 publications

References 24 publications

The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population

The mediational role of physical activity, social contact and stroke on the association between age, education, employment and dementia in an Asian older adult population

The Singaporean public beliefs about the causes of mental illness: results from a multi-ethnic population-based study

Aerobic exercise ameliorates learning and memory deficits of aging rats induced by D-galactose via promoting SYP and BNDF expression in hippocampus

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