Prevalence of dementia and cognitive impairment in Southeastern Spain: the Ariadna study

Gavrila, Diana; Antúnez, Carmen; Tormo, M. José; Carles, Rafael; Santos, J.M. García; Parrilla, G.; Fortuna, Lisa R.; Jiménez, Jesús Muñoz; Salmerón, Diego; Navarro, Carmen

doi:10.1111/j.1600-0404.2009.01283.x

Cited by 74 publications

(63 citation statements)

References 42 publications

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“…Only few studies have reported that male gender is associated with a higher MCI risk [42,52] . Most studies confirm our findings for the original MCI definition with no difference in gender or report a higher prevalence rate for women [38,39] . A possible explanation could be the limited insight especially of older participants and men into cognitive impairments as part of the MCI-original diagnosis.…”

Section: Discussionsupporting

confidence: 78%

“…According to the MCI-modified criteria, a higher prevalence rate was found (12.1%), which also falls within the reported range of 5-42% of other population-based studies [34,[37][38][39] . This is also consistent with the finding that the modified diagnoses are more common than the original [34] , which may be due to the fact that requiring one criterion less increases the sensitivity but reduces the specificity of the MCI concept.…”

Section: Discussionsupporting

confidence: 65%

“…A follow-up examination of our cohort therefore will enable us to examine the importance and predictive value of subjective cognitive impairment for the progression to dementia. Regarding the education-specific prevalence rate, there is a decrease in MCI (original and modified) in participants with higher education levels, as reported in several studies [32,35,38,39] .…”

Section: Discussionsupporting

confidence: 49%

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Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Dlugaj

Weimar

Wege³

et al. 2010

Dement Geriatr Cogn Disord

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Aims: We investigated the prevalence of mild cognitive impairment (MCI) and its subtypes according to the original (MCI-original) and modified (MCI-modified; neglecting cognitive complaints) Petersen criteria. Methods: 4,145 subjects (aged 50–80 years) from a German population-based study completed a cognitive screening test and were poststratified into 2 groups with sample sizes of 1,125 for impaired and 3,020 for age-appropriate performance. Random samples of 445 impaired participants and 211 age-appropriate participants received a detailed neuropsychological evaluation. The prevalence of MCI was estimated by a bias correction estimator based on stratum weights. The association between MCI and age, gender and education was analyzed in a logistic regression model. Results: The estimated MCI prevalence was 7.8% (95% CI: 5.7–9.9%) for the original, and 12.1% (95% CI: 9.8–14.4%) for the modified criteria. In the MCI-original group, amnestic MCI subtypes were slightly less common than non-amnestic MCI subtypes (3.5 vs. 4.3%). MCI-original was associated with lower education and older age. In the MCI-modified group, the amnestic subtypes were more common than the non-amnestic MCI subtypes (7.8 vs. 4.3%), and MCI was associated with age, gender and education. Conclusions: Prevalence rates of MCI are high in the general population and vary considerably according to the criteria applied.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 49%

See 1 more Smart Citation

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Dlugaj

Weimar

Wege³

et al. 2010

Dement Geriatr Cogn Disord

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“…The superior schooling of Chilean women, as well as their prolonged interactions with family members, might stimulate cognitive function (28,29) . As in other studies, a lower risk of cognitive impairment was observed in those with higher levels of education (30)(31)(32) , which might be explained by greater cognitive reserves from superior cortical and neuronal synaptic capacities or improved compensation for deficiencies arising from other brain regions (33,34) . Although the difference in SF levels was statistically significant when comparing our participants with normal and impaired cognitive function (MMMSE plus PFAQ), it should be noted that in both cases SF levels were within the normal range, reaching supraphysiological levels (>20 μg/l) (35) in the group with normal cognitive function.…”

Section: Discussionsupporting

confidence: 53%

Serum folate, vitamin B₁₂ and cognitive impairment in Chilean older adults

Castillo-Lancellotti

Margozzini

Valdívia

et al. 2015

Public Health Nutr.

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Objective: To analyse the relationship between serum folate (SF), vitamin B 12 and impaired cognitive function in the Chilean elderly. Design: We analysed the relationships between impaired cognitive function and age, SF (µg/l) and vitamin B 12 (pg/ml) with Student's t test, as well as between impaired cognitive function and gender, educational level, residence area, diabetes and hypertension with the χ 2 test. Multiple logistic regressions with interactions were estimated to assess the impact of SF on impaired cognitive function according to these methods. Setting: Chile. Subjects: Older adults (>65 years, n 1051), drawn from representative households of a national prevalence study, assessed using the Modified Mini Mental Status Examination (MMMSE). Individuals with altered MMMSE scores (≤13 points) were sequentially assessed using the Pfeffer Functional Activities Questionnaire (PFAQ). Results: Multivariate models using the MMMSE demonstrated an increased risk of impaired cognitive function for seniors who had hypertension, diabetes and higher vitamin B 12 levels. SF and its square (SF 2 ) were statistically significant, indicating that this predictor of impaired cognitive function displays a U-shaped distribution. The interaction between SF and vitamin B 12 was not statistically significant. Models using the MMMSE plus PFAQ suggested that urban residence decreased the risk of impaired cognitive function, whereas male gender, older age, vitamin B 12 levels and hypertension increased this risk. The variables SF and SF 2 and the SF × vitamin B 12 interaction were statistically significant (P < 0.05). The risk of impaired cognitive function depended on different combinations of SF and vitamin B 12 levels. When SF was low, a one-unit increase in SF (1 µg/l) diminished the risk. When SF was elevated, a further increase in SF raised the risk, especially at low vitamin B 12 levels. Conclusions: The relationship between folate, vitamin B 12 and impaired cognitive function warrants further study.

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“…Large differences are found between the prevalence of CIND among rural and urban populations. Two studies in Spain reported CIND prevalence rates of 13.8 and 14.7% in an urban setting [16,17] compared to 23.3% found in a rural setting [17]. Similarly, in a study of the Beijing population, Tang et al [18] reported that CIND was higher in rural locations compared to urban locations (18.8 vs. 6.9%, respectively).…”

Section: Discussionmentioning

confidence: 94%

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Shi

Zhang²,

Yue³

et al. 2013

Dement Geriatr Cogn Disord

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Aims: The aim of this study was to estimate the prevalence of cognitive impairment (CI) in individuals aged 80 years and over in rural China and to analyze the associated risk factors. Methods: We conducted a two-phase door-to-door survey of a population in rural Ji County (China). The reference population consisted of individuals aged 80 years or older. A total of 723 individuals were interviewed in their homes, and demographic variables and comorbidities were recorded. Diagnoses were divided into the following 3 categories: normal cognitive function, cognitive impairment no dementia (CIND), and dementia. The odds ratio for each risk factor was calculated by logistic regression analysis. Results: The prevalence of CI among individuals aged 80 years and older was 73.2% (47.4% CIND and 25.7% dementia). The risk of CI decreased with a higher level of education and a higher level of social involvement. The risk of CI was higher in females than in males and among people with a history of stroke (p < 0.01). Conclusions: The observed raw prevalence of CI was 73.2%. Female gender and a history of a previous stroke increased the risk of CI, while a higher educational level and engagement in social activities reduced the risk of CI.

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Prevalence of dementia and cognitive impairment in Southeastern Spain: the Ariadna study

Abstract: The prevalence of dementia was low, despite a high prevalence of aMCI and CIND. Dementia was strongly associated with age and education. CIND was associated with living in a rural area and with female sex, while aMCI was associated with illiteracy.

Cited by 74 publications

References 42 publications

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Serum folate, vitamin B₁₂ and cognitive impairment in Chilean older adults

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

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Prevalence of dementia and cognitive impairment in Southeastern Spain: the Ariadna study

Abstract: The prevalence of dementia was low, despite a high prevalence of aMCI and CIND. Dementia was strongly associated with age and education. CIND was associated with living in a rural area and with female sex, while aMCI was associated with illiteracy.

Cited by 74 publications

References 42 publications

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort

Serum folate, vitamin B12 and cognitive impairment in Chilean older adults

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Contact Info

Product

Resources

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Serum folate, vitamin B₁₂ and cognitive impairment in Chilean older adults