Prevalence of cystic fibrosis in children who present with nasal polyposis

Avaliação endoscópica nasal de crianças e adolescentes com fibrose cística

“…From 1961 to 2005, the prevalence of nasal polyps increased from 5 to 57%. 26,29,[31][32][33][34][35][36][37][38][40][41][42] Explanations include increased survival rates of CF patients in developed countries, the selection of patients, sample sizes, different age groups in these studies, and especially the more recent routine use of nasal endoscopy as a diagnostic tool. 3,19,48 Brihaye et al 29 showed that over 25% of polyps were not diagnosed in the clinical examination with anterior rhinoscopy without nasal endoscopy in CF patients.…”

“…Studies of children and adolescents only have shown varying frequencies of nasal polyps: 22.2% of 27 CF patients by Denoyelle et al 36 in France, 57% of 23 CF patients by Yung et al 19 in England, and 32.6% of 89 patients by Cimmino et al 6 in Italy. Schmitt et al 41 retrospectively evaluated the medical files of 893 children with CF -the largest sample of this disorder in the literature -and found nasal polyps in only 5% of subjects.…”

“…[28][29][30] The frequency of nasal polyposis varies in different populations, and depends on the evaluation technique. 26,29,[31][32][33][34][35][36][37][38][39][40][41][42] It is thought that nasosinusal involvement may worsen pulmonary manifestations; 20 thus, otorhinolaryngologists have become more involved in evaluating these patients. Recent studies in Brazil 26,40,41 have shown a growing concern with characterizing in more detail the nasosinusal findings of CF patients, because this disorder is genetically very heterogeneous, with many types of mutations and a wide variety of clinical presentations, 28 which may be explained by specific phenotypic features of the Brazilian population and even within populations of any given region in this country.…”

Incidência e evolução da polipose nasal em crianças e adolescentes com fibrose cística

“…In the present study, the incidence of nasal polyposis was similar to the one reported in the literature; however, consider the finding of 39.1% of children and adolescents with high levels of polyposis, because the aforementioned studies included adults in their series. When patients below 10 years of age were assessed, the incidence reported was between 5 and 15.2% 16,18 . Schmitt et al 18 in 2005, assessing 893 children with CF, found nasal polyps in only 5% of the children, and in 0.2% cystic fibrosis was diagnosed due to the presence of polyps.…”

“…When patients below 10 years of age were assessed, the incidence reported was between 5 and 15.2% 16,18 . Schmitt et al 18 in 2005, assessing 893 children with CF, found nasal polyps in only 5% of the children, and in 0.2% cystic fibrosis was diagnosed due to the presence of polyps. This is a very important piece of data, because although the isolated polyp does not always mean cystic fibrosis, the otolaryngologist must investigate it because of its severity and importance in early diagnosis and treatment in order to provide a better survival prognosis.…”