Prevalence of cutaneous leishmaniasis in the largest populated city Karachi, Pakistan

Ihsanullah,; Yousuf, Masarrat; Ahmad, Naveed; Masood, Zubia; Majeed, Saima; Hassan, Habib Ul; Ibrahim, Moustafa O; Khooharo, A. R.; Khooharo, E.; Mastoi, Abdul Hafeez; Zafar, Nazarov; Shaikh, Faheemullah

doi:10.1590/1519-6984.247583

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Moreover, the majority of the reported CL patients were in the 15 years and above age group, and the lowest number was in age group of <5 years. These findings are in constancy with those reported worldwide [ 30 , 31 ]. However, CL tends to more affect younger age group has also been reported in some leishmaniasis endemic areas [ 32 - 34 ].…”

Section: Discussionsupporting

confidence: 92%

Cutaneous leishmaniasis in Tabuk, Saudi Arabia: epidemiological trends from 2006 to 2021

Hassanei¹,

El-Shemi²,

Albalawi³

2023

Pan Afr Med J

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Introduction cutaneous leishmaniasis (CL) is a vector-borne protozoan skin disease that affects all human ages and can pose extreme social and psychological impacts. This study aimed to reveal the epidemiological trends of CL in the Tabuk region, the Kingdom of Saudi Arabia (KSA), during the period from 2006 to 2021. Methods patients with CL, who were detected and registered at the regional Vector-borne Diseases Control Unit of the Tabuk province, between January 2006 and December 2021, were analyzed in this retrospective study. The patients´ data included their nationality, gender, and age, and their annual and month-by-month recorded patterns. Results a total of 1575 CL patients were reported during the said period. They were 53.1% Saudis and 46.9% non-Saudi expatriates with a ratio around 1.1: 1.0; and they were re-categorized as 83.17% males and 16.83% females with a ratio of 4.9: 1.0 (p <0.5). Additionally, the majority (1002/1575; 63.6%) of these CL patients were in age group of 15-45 years (p <0.5), and the lowest number was in age group of <5 years. Most importantly, there was a continuous annual and month-by-month record of these patients; reflecting CL endemicity in the Tabuk region of KSA. Conclusion the present findings imply that CL is endemic in the Tabuk region of KSA. As there is a recent increase in human immigration to this region, sustainable monitoring of CL and improving its control measures is warranted.

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Section: Discussionsupporting

confidence: 92%

Cutaneous leishmaniasis in Tabuk, Saudi Arabia: epidemiological trends from 2006 to 2021

Hassanei¹,

El-Shemi²,

Albalawi³

2023

Pan Afr Med J

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“…The study conducted by Ali J also found these two as the frequently encountered bullous lesions 23 . Among infections, viral warts and leishmaniasis appeared most prevalent in accordance with several other researches 24,25,26 . Psoriasis and Lichen Planus were the frequent papulosquamous disorders relatable with the studies by Ndukwe CO and Gandhi J 9,27 .…”

Section: Discussionsupporting

confidence: 88%

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Ali¹,

Ali²,

Kanwar³

et al. 2023

PJMHS

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Introduction: Skin ailments share a major disease burden worldwide (1, 2).They are considerably frequent in underdeveloped nations and encompass simple ailments like inflammation and pimples to certain grave diseases like skin melanomas (3). However, the type and prevalence of skin disorders differ from area to area on account of dissimilar habitat (4, 5). Skin disorders influence human lives in various ways and many a times the dermal epidermal conditions point some internal ongoing serious disease (6). A vast majority of skin diseases are treated on the basis of clinical diagnosis without confirmation through biopsy. Microscopic examination is mandatory for verification and precise diagnosis and to direct the clinician to opt suitable treatment (7). Considering their importance, the research work being done on the prevalence of specific disorders in particular regions in our country appears deficient especially considering the clinicopathological consonance. The current research was outlined to acumen the skin diseases related burden in our institute. Aim & Objective: The aim of this research is to evaluate the histopathological diversity of skin diseases and their prevalence in Multan region along with the clinic-pathological consonance. Study Design: Retrospective cross sectional study Place and Duration: Histopathology and dermatology departments of Bakhtawar Amin Medical & Dental College and Trust Hospital Multan, from January 2020 to December 2022. Material and Methods: Histopathological reports of all skin biopsies were sorted. The required data like age, gender, clinical presentation, site of the lesion, dermatologist’s findings, and their clinical provisional impression with differential diagnoses were documented along with the histopathological microscopic opinion. The particulars were gathered from clinical files, histopathological demand forms and documented reports. Results: A sum of 510 skin biopsies was received in histopathology section. Out of these, 280 (54.9%) were females and remaining 230 (45.1%) were males. The mean age was 34.70 years (ranging from 2 to 84 years). Most of them were between ages 16-30 years. Majority of the lesions were benign non cancerous and related to skin appendages. Epidermal inclusion cyst appeared to be the most prevalent. Out of 510 biopsies, 68 (13.3%) turned out to be malignant neoplasms. Conclusion: A vast majority of skin diseases are treated only on the basis of clinical diagnosis. The present study revealed that the histopathological opinion was consistent with the clinical judgment in 63 % of the cases, unveiling the significance of histopathological examination that is must for saving time and expenses of the patients. It also helps in reduction of the morbidity related to various skin disorders Keywords: Histopathology, dermatology, skin disorders, skin cancers, epidermal inclusion cyst

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“…Additionally, the population affected by the disease suffers from the social stigma resulting from disfiguring deformities and scars, significantly impacting their quality of life (Brasil, 2021). Ihsanullah et al (2023) observed a higher percentage of lesions on the face, arms, and legs.…”

Section: Discussionmentioning

confidence: 82%

Leishmanicidal activity of the venoms of the Scorpions Brotheas amazonicus and Tityus metuendus

Pereira,

Martins,

Oliveira

et al. 2023

Braz. J. Biol.

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Leishmaniasis is a vector-transmitted zoonosis caused by different species of the genus Leishmania, with a wide clinical spectrum. It is a public health problem aggravated by a series of limitations regarding treatment. In the search for new therapeutic alternatives, scorpion venoms are a source of multifunctional molecules that act against the natural resistance of pathogens. This work evaluated the antileishmanial potential of Brotheas amazonicus and Tityus metuendus venoms against the promastigote forms of Leishmania amazonensis e Leishmania guyanensis. The venoms of B. amazonicus and T. metuendus were evaluated for their constituents using Fourier Transform Infrared (FTIR). Growth inhibition and death of promastigotes were evaluated in the presence of diferente crude venom concentrations (100 µg/mL, 50 µg/mL, 10 µg/mL, 1 µg/mL) after one hour of incubation at 25 °C. The FTIR spectra of both venoms exhibited bands in approximate regions, revealing that both exhibit similar functional groups. Crude venom from both scorpion species showed similar or superior leishmanicidal effects to the standart drug N-methylglucamine antimoniate. At the highest concentration of 100 µg/mL, cultures of L. guyanensis treated with the venom of B. amazonicus showed the highest mortality percentages, above 28%, while T. metuendus venom showed the highest activity against L. amazonensis, with mortality above 7%. This preliminar study demonstrates that B. amazonicus and T. metuendus venoms can be important tools in the search for new drugs Against leishmaniasis. Next step involves evaluating the activity against the amastigote forms and purifying the venom proteins in order to identify the best anti-leishmania candidates.

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Prevalence of cutaneous leishmaniasis in the largest populated city Karachi, Pakistan

Cited by 4 publications

References 14 publications

Cutaneous leishmaniasis in Tabuk, Saudi Arabia: epidemiological trends from 2006 to 2021

Cutaneous leishmaniasis in Tabuk, Saudi Arabia: epidemiological trends from 2006 to 2021

Histopathological Review of Skin Diseases: A Three Years Survey of 510 Skin Biopsies in Multan

Leishmanicidal activity of the venoms of the Scorpions Brotheas amazonicus and Tityus metuendus

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