Prevalence of culture positive Tuberculosis and utility of a clinical diagnostic tool for the diagnosis of Tuberculosis among HIV Infected Children attending HIV/AIDS Care and Treatment in Dodoma Municipality, Central Tanzania

Mutabazi, Sauda A.; Jumanne, Shakilu; Mpondo, Bonaventura C. T.; Mnzava, David Paulo

doi:10.1016/j.ijid.2020.06.001

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…7 Some studies have reported good performances with a sensitivity varying between 76.9 and 91% and specificity between 88 and 90%,while others have found poor performances with a sensitivity of 85% and a specificity of 25%. [25][26][27] In addition, the interpretation of the scoring system is biased in early stage of disease regarding duration of cough, nutritional status, lack of improvement in nutritional status, unexplained fever with no response to antimalarial drugs and/or two antibiotics. Considering the items of this score, the score could be higher in those with extrapulmonary TB than pulmonary TB.…”

Section: Discussionmentioning

confidence: 99%

Clinico-radiological criteria versus GeneXpert for diagnosis of pediatric tuberculosis

et al. 2022

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Background: Diagnosing tuberculosis in children remains a challenge especially in low-income countries. The aim of this study was to assess the performance of the scoring system combined to chest x-ray images compared to GeneXpert for diagnosis of pediatric tuberculosis.Methods: A retrospective diagnostic accuracy study was carried out on hospitalized children aged 0 to 14 years old, tuberculosis suspect in the pediatric department of the Tsaralalana mother child university hospital center from August 2018 to June 2020.Results: Fifty-one medical files were retained. The mean age was 4±2 years old with a sex ratio of 1.55. The reason for consultation was dominated by respiratory signs (56.9%). The GeneXpert was positive in 58.9% of cases. The chest X-ray images were pathological in all cases, dominated by images of condensation or infiltration (72.5%). WHO score was positive (≥7) in 72.5% of cases. The clinico-radiological criteria had a sensitivity of 13.3-63.3%, a specificity of 61.9-95.2%, positive predictive values of 1.5-6.9% and negative predictive values of 98.8-99.3%.Conclusion: Clinico-radiological criteria could be useful in individual diagnosis of pediatric tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Clinico-radiological criteria versus GeneXpert for diagnosis of pediatric tuberculosis

et al. 2022

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Diagnostic Accuracy of Clinical Diagnostic Scoring Systems for Childhood Tuberculosis: A Systematic Review and Meta-analysis

Kakinda,

Olum,

Baluku

et al. 2023

Open Forum Infectious Diseases

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Background Diagnosis of childhood tuberculosis (TB) poses several challenges. Therefore, point-based scoring systems and diagnostic algorithms have been developed to improve the diagnostic yields in this population. However, there are no updated systematic reviews of the existing childhood TB scoring systems and algorithms. Hence, we systematically reviewed the diagnostic accuracy of the childhood TB diagnostic scoring systems and algorithms. Methods We systematically searched PubMed, CINAHL, Embase, Scopus, and Google Scholar databases for relevant articles published until March 30, 2023. QUADAS-2 was used to assess their study quality. Diagnostic accuracy measures (i.e., sensitivity, specificity, diagnostic odds ratio [DOR], positive likelihood ratio [LR+], and negative likelihood ratio [LR]) were pooled using a random-effects model. All statistical analyses were performed using MetaDTA and STATA SE version 17. Results We included 15 eligible studies, with a total of 7,327 study participants aged less than 15 years, with 10 evaluations of childhood TB diagnostic scoring systems and algorithms. Among these algorithms and scoring systems, only three were evaluated more than once. These were Keith Edward’s scoring system with five studies (sensitivity-81.9% and specificity-81.2%), Kenneth Jones Criteria (sensitivity-80.1% and specificity-45.7%), and the MoH Brazil Algorithm (sensitivity: 79.9% and specificity-73.2%) with three studies each. Conclusion We recommend using the Keith Edwards scoring system because of its high sensitivity and specificity. Further research is necessary to assess the effectiveness of scoring systems and algorithms in identifying tuberculosis in children with HIV and malnutrition.

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Prevalence of culture positive Tuberculosis and utility of a clinical diagnostic tool for the diagnosis of Tuberculosis among HIV Infected Children attending HIV/AIDS Care and Treatment in Dodoma Municipality, Central Tanzania

Cited by 2 publications

References 33 publications

Clinico-radiological criteria versus GeneXpert for diagnosis of pediatric tuberculosis

Clinico-radiological criteria versus GeneXpert for diagnosis of pediatric tuberculosis

Diagnostic Accuracy of Clinical Diagnostic Scoring Systems for Childhood Tuberculosis: A Systematic Review and Meta-analysis

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