Prevalence of Coxiella burnetii in bovine bulk milk samples in southern Iran

Kargar, Mohammad; Rashidi, Afsaneh; Doosti, Abbas; Ghorbani-Dalini, Sadegh; Najafi, Akram

doi:10.1007/s00580-012-1406-9

Cited by 19 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even asymptomatic animals [ 20 ] or seronegative cattle [ 22 ] have been identified as C. burnetii milk shedders. Coxiella burnetii can be excreted in milk for up-to 13 months [ 9 , 23 ], although this may be intermittent [ 6 ]. Two patterns of shedding have been identified in dairy cows which can be persistent heavy shedders or sporadic shedders [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Ruminants, including cattle, are broadly known to be reservoirs for this bacterium. Since 2006, many research groups have evaluated the herd-level prevalence of C. burnetii in cattle by molecular techniques on composite milk samples. This study explored the global C. burnetii herd-level prevalence from studies done on bovine bulk-tank milk (BTM) samples using PCR-based analysis. Also, moderators were investigated to identify sources of heterogeneity. Databases (CAB Abstracts, Medline via Ovid, PubMed, Web of Science and Google Scholar) were searched for index articles on C. burnetii prevalence in BTM samples by PCR published between January-1973 and November-2018. Numerous studies (1054) were initially identified, from which seventeen original publications were included in the meta-analysis based on the pre-defined selection criteria. These studies comprised 4031 BTM samples from twelve countries. A random-effects model was used because of considerable heterogeneity ( I 2 = 98%) to estimate the herd-level prevalence of C. burnetii as 37.0%(CI 95% 25.2–49.5%). The average herd size appeared to account for a high level of the heterogeneity. No other moderators (geographic location, gross national income or notification criteria for Q fever) seemed to be determinant. This systematic evaluation demonstrated a high molecular prevalence of C. burnetii in BTM samples both in European and non-European countries, evidencing a widespread herd-level circulation of this agent in bovine dairy farms around the world. Meta-regression showed herd size as the most relevant moderator with the odds of a BTM sample testing positive doubling with every unit increase.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Finally, 27 studies were included in the systematic review. [ 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 ] Articles were divided into serological[ 10 11 12 13 14 15 16 17 18 19 20 21 35 ] and molecular studies. [ 22 23 24 25 26 27 28 29 30 31 32 33 34 36 ] The reasons for including or excluding the studies are categorized and reported in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Hence, ten studies were included in our meta-analysis which all of them looked for C. burnetii in milk samples from ruminants. [ 22 23 24 25 26 27 28 29 30 31 ]…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of Q fever in Iran: A systematic review and meta-analysis for estimating serological and molecular prevalence

et al. 2017

View full text Add to dashboard Cite

Background:Q fever is endemic in Iran, thus, we conducted a systematic review and meta-analysis on epidemiology of Coxiella burnetii among humans and animals in Iran.Materials and Methods:A systematic search was performed to identify all articles reporting C. burnetii prevalence in Iranian humans or animals, published from January 2000 to January 2015. Data from articles were extracted, and a pooled estimate of prevalence with corresponding 95% confidence interval (CI) was calculated using random effect method.Results:In this review, 27 papers were identified. The pooled seroprevalence of Q fever in animals was 27% (CI 95%: 23%–32%). The prevalence was 33% (CI 95%: 22%–45%) in goats, 27% (CI 95%: 21%–32%) in sheep, and 17% (CI 95%: 5%–28%) in cattle. The bacterial DNA was detected in 5% (95% CI: 3%–9%) of milk samples, and it was higher in cattle (10%; 95% CI: 6%–16%) than sheep (2%; 95% CI: 0–7%) and goats (4%; 95% CI: 0–12%).Conclusion:C. burnetii DNA or its antibody has been frequently detected among ruminants. Since these animals can transmit the infection to humans, Q fever could be a potential health problem in Iran.

show abstract

“…The prevalence of C. burnetii was 23.1% in Tehran, 15% in Hamadan, and 0% in Mazandaran provinces. Based on recent studies, the prevalence of C. burnetii was reported to be 8.6% in Isfahan province [ 23 ], 33.3% in Qom province [ 9 ], 8.3% in Zanjan province [ 19 ], and 11% in Fars province (south of Iran) [ 24 ]. Different prevalence rates of C. burnetii were reported among cattle milk from other countries: 8.7% in Hungary [ 20 ], 15.1% in Lebanon [ 17 ], 18.8% in the Netherlands [ 25 ], and 27% in Italy [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Coxiella burnetii in Raw Milk of Livestock Animal in Iran

Mobarez

Mostafavi

Khalili

et al. 2021

International Journal of Microbiology

View full text Add to dashboard Cite

Coxiella burnetii is the causative agent of Q fever in humans and animals. This study aimed to determine the frequency of C. burnetii in milk samples of dairy animals (goats, sheep, and cattle) in some selected regions in Iran, where there is no information about prevalence of C. burnetii. In this study, 162 individual milk samples were collected from 43 farms in three provinces (Tehran, Hamadan, and Mazandaran). Real-time PCR was used for the detection of IS1111a element of C. burnetii. In total, 23 of 162 samples (14.2%, 95% conﬁdence interval (CI): 9.65–20.2%) were positive for C. burnetii by real-time PCR. C. burnetii was detected in 10.17% (95% CI: 4.74–20.46) of goat milk samples. In sheep milk samples, 18.6% (95% CI: 9.74–32.62) were positive, and C. burnetii was detected in 15% (95% CI: 8.1–26.11) of cattle milk samples. Molecular evidence of the presence of C. burnetii was seen in milk samples of dairy animals in all the studied regions. These findings demonstrated that C. burnetii infection, especially in raw milk samples, deserves more attention from the health care system and veterinary organization in Iran.

show abstract

Prevalence of Coxiella burnetii in bovine bulk milk samples in southern Iran

Cited by 19 publications

References 16 publications

Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis

Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis

Epidemiology of Q fever in Iran: A systematic review and meta-analysis for estimating serological and molecular prevalence

Identification of Coxiella burnetii in Raw Milk of Livestock Animal in Iran

Contact Info

Product

Resources

About