Prevalence of Coronary Atherosclerosis in Northern India

Wig, K L; Malhotra, Rajeev; Chitkara, N. L.; Gupta, Sandeep

doi:10.1136/bmj.1.5277.510

Cited by 15 publications

(7 citation statements)

References 6 publications

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“…11 Virmani et al also observed that maximum cases were seen between fourth and fifth decades of life and advanced atherosclerotic lesions were predominant in this age group. 12 In our study also, advanced atherosclerotic lesions were more commonly seen in older age groups, viz fifth to seventh decades of life ( [13][14][15][16][17][18] Marwah et al also found significant atherosclerosis in hearts of all cases more than 70 years of age, in their autopsy study on sudden cardiac deaths. 19 In our study, male to female ratio was 4.3:1 with 76.5% males and 23.5% of cases being females.…”

Section: Discussionsupporting

confidence: 57%

Morphological spectrum of atherosclerotic lesions in a tertiary care Institute in Punjab

Kumar¹,

Tyagi

Singh³

et al. 2018

Asian J Med Sci

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Background: The incidence of coronary artery disease (CAD) has risen considerably in developing world due to industrialization, urbanisation and lifestyle changes, especially among Indians and South Asians. The onset of CAD has been seen to occur at an early age and the severity of the disease and mortality associated with CAD has also increased. The pathology of atherosclerosis needs to be re-evaluated to develop targeted therapy which can contain the disease process at the earliest stage. Aims and Objectives: Most of the morphological studies on atherosclerosis have been done on autopsy cases. In this study, we have analysed the morphological spectrum of atherosclerotic lesions in live patients. Materials and Methods: We retrospectively analysed the histopathology slides of 85 cases whose endarterectomy plaques were received in the Department of Pathology over a period of three and half years (January 2014 to June 2017) and classified the lesions according to Modified American Heart Association classification of atherosclerosis. Results: The average age of patients was 60 years and male to female ratio of 4.3:1. Left anterior descending artery was the commonest vessel involved (52.4%). Majority of the cases had fibrocalcific plaques,followed by fibrous cap atheroma and calcified nodules. Conclusion: Coronary artery plaques were found even in patients less than 40 years old. Aggressive lipid defense therapy needs to be the cornerstone of management of CAD.

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Section: Discussionsupporting

confidence: 57%

Morphological spectrum of atherosclerotic lesions in a tertiary care Institute in Punjab

Kumar¹,

Tyagi

Singh³

et al. 2018

Asian J Med Sci

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“…Overall incidence of significant atherosclerotic lesions was 25.11% in right and 29.76% in left coronary artery. Earlier studies also in India by Wiget al [32] found significant atheroma in two-third of cases above the age of 20 years while Tandon [22] found atherosclerosis in second and thirddecade. Singh et al [20] found atherosclerosis atthe age of 17 years.…”

Section: Discussionmentioning

confidence: 94%

Correlation of coronary artery atherosclerosis typing and luminal narrowing with ischemic myocardial lesions in post mortem heart specimens: a four year retrospective study

Singh

Satarkar

Kalhan

et al. 2018

Trop J Pathol Microbiol

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Introduction: Atherosclerosis accounts for a large proportion of cardiovascular system associated morbidity and mortality. Coronary artery disease (CAD) is the leading cause of global deaths with about 80% of burden occurring in developing countries. Material & Methods: In order to assess the magnitude of the problem, a retrospective study of autopsy cases for the presence of atherosclerotic lesions of coronary arteries and associated ischemic cardiac lesionswas under taken from January 2013 to December 2017. Also, correlation of the atherosclerosis with ischemic heart diseases was studied. Result: Total number of heart specimens received in department of Pathology during four years were 272. Out of these 57 were autolyzed and were excluded from the study. Significant atherosclerotic lesions were seen in 54(25.11%) and 64(29.76%) cases in right and left coronary arteries respectively and were statistically significantly higher among age group > 41 years as compared to those with age <41 years, overall atherosclerotic lesions were significantly higher in age groups >41 years as compared to <41 years. Conclusion: Maximum number of significant cardiac lesion were associated with atherosclerotic type VIII lesions (75%) followed by type VII (66.66%) and type VI (33.33%). Maximum number of significant myocardial lesions were associated with grade IV (66.66%) coronary luminal narrowing followed by grade III (45.71) and grade II (38.46). The study also showed significant correlation between the higher grade of the coronary atherosclerotic lesions and the ischemic heart disease.

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“…Populations in which important data have been collected are among white, Bantu and other racial groups [150-1611 in Africa, the various ethnic subdivisions in Israel [162-1691, groups in India [170-1781, Japan [179-1831, China [184, 1851, the Pacific area [186-1921and in South and Central America [193-1971 It seems fair to conclude from these studies that, in general, the frequency of coronary heart disease is greater among the groups with higher socio-economic standards, though there may be epidemiologically important exceptions to this rule which demand further study [70]. This conclusion has little meaning in itself unless the factors related to these gradients can be identified.…”

Section: International Comparisonsmentioning

confidence: 99%

The epidemiology of coronary heart disease

Epstein

1965

Journal of Chronic Diseases

217

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Prevalence of Coronary Atherosclerosis in Northern India

Abstract: We thank Mr. M. P. Curwen for statistical advice and Miss W. Smith for her help in the follow-up study.

Cited by 15 publications

References 6 publications

Morphological spectrum of atherosclerotic lesions in a tertiary care Institute in Punjab

Morphological spectrum of atherosclerotic lesions in a tertiary care Institute in Punjab

Correlation of coronary artery atherosclerosis typing and luminal narrowing with ischemic myocardial lesions in post mortem heart specimens: a four year retrospective study

The epidemiology of coronary heart disease

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