Prevalence of COPD in 6 Urban Clusters in Argentina: The EPOC.AR Study

Echazarreta, Andrés L.; Arias, Sergio; Olmo, Ricardo del; Giugno, Eduardo; Colodenco, Federico D.; Arce, Santiago C.; Bossio, Juan Carlos; Armando, Gustavo; Soriano, Joan B.

doi:10.1016/j.arbr.2017.09.017

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…Data from the population-based Latin-American Pulmonary Obstruction Investigation Project (PLATINO) study indicates that patients were distributed as follows: 69% in group A, 26% in group B, 2% in group C, and 3% in group D [ 8 ]. Similar distribution was found in another population-based study from Argentina (A: 52%, B: 43%, C: 1% and D: 4%) [ 9 ].…”

Section: Introductionsupporting

confidence: 87%

Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmornary Disease? What Do We Need to Add?

Laucho-Contreras

2018

Medical Sciences

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Acute exacerbations in chronic obstructive pulmonary disease (AECOPD) are associated with increased mortality, rate of hospitalization, use of healthcare resources, and have a negative impact on disease progression, quality of life and lung function of patients with chronic obstructive pulmonary disease (COPD). There is an imperative need to homogenize the definition of AECOPD because the incidence of exacerbations has a significant influence or implication on treatment decision making, particularly in pharmacotherapy and could impact the outcome or change the statistical significance of a therapeutic intervention in clinical trials. In this review, using PubMed searches, we have analyzed the weaknesses and strengths of the different used AECOPD definitions (symptom-based, healthcare-based definition or the combinations of both), as well as the findings of the studies that have assessed the relationship of different biomarkers with the diagnosis, etiology and differential diagnosis of AECOPD and the progress towards the development of a more precise definition of COPD exacerbation. Finally, we have proposed a simple definition of AECOPD, which must be validated in future clinical trials to define its accuracy and usefulness in daily practice.

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Section: Introductionsupporting

confidence: 87%

Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmornary Disease? What Do We Need to Add?

Laucho-Contreras

2018

Medical Sciences

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“…64 This is primarily related to poor access to spirometry and limited epidemiological data, but is compounded by controversy in the definition of COPD -for example it is unclear whether fixed ratios and percent predicted cut-offs or lower limit of normal (LLN) boundaries should be used to identify abnormal results, which reference ranges to use for standardisation of measurements, and whether to consider all patients with fixed airflow limitation as having COPD. 7 Notwithstanding this, community based data indicate that the prevalence of airway obstruction is between 6-20% in Latin America, [65][66][67] and 5-24% in sSA. [68][69][70][71] It is thought that LMICs contribute to 76.5% of the global COPD burden, 85% of global COPD deaths and 85% of the global COPD DALYs (Figure 1).…”

Section: Copdmentioning

confidence: 99%

Improving lung health in low-income and middle-income countries: from challenges to solutions

et al. 2021

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Low-and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease, bronchiectasis and post-tuberculous lung disease. CRDs are strongly associated with poverty, infectious diseases, and other non-communicable diseases, and contribute to complex multi-morbidity, with significant consequences for the lives and livelihoods of those affected.The relevance of CRDs to health and socioeconomic wellbeing is expected to increase over time, as life expectancies rise and the competing risks of early childhood mortality and infectious diseases plateau. As such, the World Health Organization has identified the prevention and control of CRDs as an urgent development issue and essential to the achievement of the Sustainable Development Goals.In this review we focus on CRDs in low-and middle-income settings (LMICs). We discuss the early life origins of CRDs, challenges in prevention, diagnosis and management in LMICs, and pathways to solutions to achieve true Universal Health Coverage.

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“…In COPD all epidemiological markers coincide in showing COPD as a major condition with a high prevalence, high morbidity, with a high impact on the relationship between quality and quantity of life, and constituting a high burden for the health system [7]. The study of the disease prevalence progression and its determinants has represented one of the key aspects of research worldwide [8][9][10][11]. In particular, the identification of prevalence determinants including sex, age, tobacco prevalence, and poverty among others, depicts the situation of specific geographical areas to target for an intervention.…”

Section: Will Epidemiologic Markers Improve In the Next Decade?mentioning

confidence: 99%

Ten Research Questions for Improving COPD Care in the Next Decade

Lόpez-Campos

Rodríguez

Quintana‐Gallego

et al. 2019

COPD: Journal of Chronic Obstructive Pulmonary Disease

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With the 60th anniversary of the CIBA symposium, it is worth evaluating research questions that should be prioritized in the future. Coming research initiatives can be summarized in main areas. 1. From epidemiology the impact of new forms of electronic cigarettes on prevalence and mortality of COPD will be sought. 2. The study of the disease endotypes and its relationship phenotypes will have to be unraveled in the next decade. 3. Diagnosis of COPD faces several challenges opening the possibility of a change in the definition of the disease itself. 4. Patients' classification and risk stratification will need to be clarified and reassessed. 5. The asthma-COPD overlap dilemma will have to be clarified and define whether both conditions represent one only chronic airway disease again. 6. Integrating comorbidities in COPD care will be key in a progressively ageing population to improve clinical care in a chronic care model. 7. Non-pharmacological management have areas for research including pulmonary rehabilitation and vaccines. 8. Improving physical activity should focus research because of the clear prognostic impact. 9. Pharmacological therapies present several challenges including efficacy and safety issues with current medications and the development of biological therapy. 10. The definition, identification, categorization and specific therapy of exacerbations will also be an area of research development.During the next decade we have a window of opportunity to address these research questions that will put us on the path for precision medicine.

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Prevalence of COPD in 6 Urban Clusters in Argentina: The EPOC.AR Study

Cited by 13 publications

References 30 publications

Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmornary Disease? What Do We Need to Add?

Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmornary Disease? What Do We Need to Add?

Improving lung health in low-income and middle-income countries: from challenges to solutions

Ten Research Questions for Improving COPD Care in the Next Decade

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