Prevalence of Congenital Toxoplasmosis in Pregnant Women with Complicated Pregnancy Outcomes in Assiut Governorate, Egypt

Mandour, A. M.; Mounib, Mahmoud Elhady Mouhamad; Eldeek, Hanan E. M.; Ahmad, Alzahraa Abdel Raouf; Kader, Abdel Rahman Mahmoud Mouhamad Abdel

doi:10.14737/journal.jap/2017/4.1.1.8

Cited by 13 publications

(15 citation statements)

References 21 publications

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“…Comparable findings were reported from Ethiopia [18], Tobago [40] and Brazil [51]. Different findings to this study were reported from Ethiopia [15, 16], Egypt [37], Mexico [50] and Burkina Faso [52].…”

Section: Discussioncontrasting

confidence: 92%

“…The highest T.gondii antibodies were found 213 (43.2%) in those pregnant women in the third trimester and there was a statistically significant association between the gestational age at (first, second and third trimester) and seropositivity of T.gondii antibody. This result is in agreement with other studies reported from Ethiopia [17] and Saud Arabia [33] but different reports from this finding were reported from Ethiopia [18, 31], Rwanda [30] and Egypt [37]. In this study 168(53.9%) of the participants had at least elementary education however, no significant difference was observed between the different levels of education.…”

Section: Discussionsupporting

confidence: 91%

“…( P = 0.826) (AOR = 0.939; 95% CI (0.535–1.648).The finding was in agreement with other studies reported from Ethiopia [15, 39], Korean [46] and Mexico [50]. Incomparable results were reported from Buenous Ires [11] Ethiopia [16] and Egypt [37]. This might be due to the difference in feeding habits and personal hygiene practice of the study participants.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, a significant association was observed between seroprevalence and ingestion of raw meat (OR = 0.848, 95% CI 1.517–1.941, P = 0.019) and similar findings were reported from other studies in Ethiopia [18, 39], Egypt [37] and Khartoum Sudan [49]. However, inconsistent findings were reported from Ethiopia and Turkey [16, 32] and Mexico [29, 50].…”

Section: Discussionsupporting

confidence: 89%

“…Drinking of unpasteurized milk was significantly associated with seropositivity of T. gondii (OR = 0.871, 95% CI, 1.531–2.221, P = 0.033). Consistent results were reported from London [7], Khyber [33] and Egypt [37]. Inconsistent results in this study were reported from Ethiopia [16, 32], Cameroon [36] and Burkina Faso [43].…”

Section: Discussionsupporting

confidence: 87%

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Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia

Fenta

2019

BMC Infect Dis

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BackgroundToxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii. It is acquired by consumption of raw or undercooked meat containing tissue cyst, food or water contaminated with oocyst and congenital infection through the placenta leading to serious congenital abnormalities in the fetus like miscarriage, stillbirth, intrauterine death and neurologic defects. Therefore; this study was aimed to determine the prevalence of toxoplasmosis infection and its possible risk factors associated with pregnant women attending antenatal clinics in Hawassa and Yiregalem Hospitals, Southern Ethiopia.MethodsA hospital-based cross-sectional study was conducted from December 2016 to May 2017. The study was done in antenatal care clinics of Hawassa and Yiregalem Hospitals in Southern, Ethiopia. Five hundred pregnant women were interviewed with a pretested structured questionnaire to collect risk factors and socio-demographic data. Blood samples were collected and serum was separated and tested for anti- Toxoplasma gondii antibodies using ELISA (Enzyme-linked Immunosorbent Assay). Data were analyzed using SPSS version 20 statistical software. The risk factors were tested for significance using Bivariate and multivariate analysis. P-value < 0.05 was considered statistically significant.ResultsThe weighted prevalence of this study was 81.8% for the anti- Toxoplasma gondii antibody. Almost all participants (99.6%) had no information about the disease. A significant association was observed between seroprevalence and contact with domestic cats (OR = 1.206, 95% CI (1.627–2.206, P = 0.043), consumption of raw meat (OR = 0.848, 95% CI: 1.517–2.941, P = 0.019) and unpasteurized milk (OR = 0.871, 95% CI 1.531–2.221, P = 0.032). A significant association was not observed between seroprevalence and age, history of abortion, and blood transfusion.ConclusionsThe findings of this study demonstrated a relatively higher prevalence of seropositivity than studies reported from other countries. Existence of domestic cats at home, consumption of undercooked meat and unpasteurized milk were identified as risk factors for T. gondii infection. Therefore, a health education program to increase the mother’s knowledge about toxoplasmosis towards avoiding eating undercooked meat, contact with cats and consumption of unpasteurized milk during pregnancy is recommended. Furthermore, our results suggested that the implementation of newborn screening and follow-up testing can lead to reducing of toxoplasmosis associated complications.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

See 3 more Smart Citations

Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia

Fenta

2019

BMC Infect Dis

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A review on toxoplasmosis in humans and animals from Egypt

Abbas

Villena

2019

Parasitology

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The present paper summarizes prevalence, epidemiology and clinical disease of natural Toxoplasma gondii infections in humans and animals from Egypt. The current situation of toxoplasmosis in Egypt is confusing. There is no central laboratory or group of researchers actively investigating toxoplasmosis in humans or animals, and no reports on the national level are available. Based on various serological tests and convenience samples, T. gondii infections appear highly prevalent in humans and animals from Egypt. Living circumstances in Egypt favour the transmission of T. gondii. Up to 95% of domestic cats, the key host of T. gondii, are infected with T. gondii; they are abundant in rural and suburban areas, spreading T. gondii oocysts. Many women have been tested in maternity clinics, most with no definitive diagnosis. Toxoplasma gondii DNA and IgM antibodies have been found in blood samples of blood donors. Clinical toxoplasmosis in humans from Egypt needs further investigations using definitive procedures. Reports on congenital toxoplasmosis are conflicting and some reports are alarming. Although there are many serological surveys for T. gondii in animals, data on clinical infections are lacking. Here, we critically review the status of toxoplasmosis in Egypt, which should be useful to biologist, public health workers, veterinarians and physicians.

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In silico study to explore the mechanism of Toxoplasma-induced inflammation and target therapy based on sero and salivary Toxoplasma

Hassanein,

Fadel,

Shehata

et al. 2024

Sci Rep

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We aimed to assess salivary and seroprevalence of Toxoplasma immunoglobulins in risky populations and evaluate drug docking targeting TgERP. A cross-sectional study was conducted in Alexandria University hospitals’ outpatient clinics. 192 participants were enrolled from September 2022 to November 2023. Anti-Toxoplasma IgG and IgM were determined in serum and saliva by ELISA. An in-Silico study examined TgERP’s protein–protein interactions (PPIs) with pro-inflammatory cytokine receptors, anti-inflammatory cytokine, cell cycle progression regulatory proteins, a proliferation marker, and nuclear envelope integrity-related protein Lamin B1. Our findings revealed that anti-T. gondii IgG were detected in serum (66.1%) and saliva (54.7%), with 2.1% of both samples were positive for IgM. Salivary IgG had 75.59% sensitivity, 86.15% specificity, 91.40% PPV, 64.40% NPP, 79.17% accuracy and fair agreement with serum IgG. On the other hand, the sensitivity, specificity, PPV, NPV, and accuracy in detecting salivary IgM were 75.0%, 99.47%, 75.0%, 99.47%, and 98.96%. AUC 0.859 indicates good discriminatory power. Examined synthetic drugs and natural products can target specific amino acids residues of TgERP that lie at the same binding interface with LB1 and Ki67, subsequently, hindering their interaction. Hence, salivary samples can be a promising diagnostic approach. The studied drugs can counteract the pro-inflammatory action of TgERP.

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Prevalence of Congenital Toxoplasmosis in Pregnant Women with Complicated Pregnancy Outcomes in Assiut Governorate, Egypt

Cited by 13 publications

References 21 publications

Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia

Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia

A review on toxoplasmosis in humans and animals from Egypt

In silico study to explore the mechanism of Toxoplasma-induced inflammation and target therapy based on sero and salivary Toxoplasma

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